Field Data
UniProt Accession: A1A4S6
Gene Name: ARHGAP10
Gene Synonim:
GAP/GEF: GAP
Description: Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10)
Keywords: 3D-structure;Cell membrane;Complete proteome;Cytoplasm;GTPase activation;Membrane;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 79658
Ensembl Gene ID: ENSG00000071205
Ensembl Protein ID: ENSP00000336923
Our Specificity RhoA
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane
GO:0048471perinuclear region of cytoplasm
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043066negative regulation of apoptotic process
GO:0007010cytoskeleton organization
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle
R-HSA-211728Regulation of PAK-2p34 activity by PS-GAP/RHG10

KEGG

Kegg ID Description
hsa05100Bacterial invasion of epithelial cells
Field Data
Localization in this study: cytosolic
Localization in the literature:

Confocal Images

Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP10
atggggctgcagcccctggagttcagcgactgctacctcgacagcccgtggttccgggag
aggatccgcgctcacgaagcggaactcgagaggaccaacaagttcatcaaagagctcatt
aaggacgggaagaacctcatcgctgcgacgaaaagtctgtcagtggcccagcggaagttt
gctcattcactcagagactttaagtttgagtttatcggtgatgctgtgacagatgatgaa
cgatgcatagatgcttccttacgtgaattttcaaattttttgaagaatctggaggaacag
agagaaattatggcattaagtgtaactgaaaccctgattaaacccttggaaaaattcaga
aaagagcaacttggagctgtaaaggaagaaaaaaagaagtttgacaaagagacagaaaag
aattatagtctaattgataaacatttgaatttatcagcaaaaaagaaagactcacattta
caagaggcagatatccaagtagagcagaaccggcaacacttctatgaactgtctctcgag
tatgtgtgtaagctgcaggaaatccaagaaagaaagaagtttgagtttgtggaacctatg
ctgtcattttttcaggggatgtttaccttctatcatcagggccatgaacttgccaaagac
ttcaatcactacaaaatggaactacagatcaacattcagaatacacggaatcgatttgaa
ggaacaaggtcagaagtggaagagctcatgaacaaaatcagacagaatcccaaggaccac
aaacgagcaagtcagtttacagccgaaggctacctgtatgtccaggaaaaaaggcctgct
ccgtttggttccagttgggtcaaacactattgcatgtatcgaaaagcagcaaagaagttc
aacatgatcccatttgagcacagatctggagggaaacttggggacggagaggtgttcttt
ttgaaagaatgtaccaagaggcatactgactccattgacagaaggttttgttttgacata
gaagctgctgatcggcctggcgtttccttgaccatgcaggcattttccgaagaggaaagg
aagcagtggttggaagctctgggtggaaaggaagctctgtcccatagttttaatacagcc
atcatcccaagaccagaaggaaatgcacagttggataagatggggttcacaattatcaga
aaatgcatcagtgccgttgaaacacgaggtataaatgaccaaggattgtacagagttgtg
ggggtgagttcaaaggtccagagacttctgagtatgttgatggatgtaaaaacatgcaat
gaggtggacctggagaattctgcagattgggaagtgaagacaataacaagtgccttgaaa
cagtatttgaggagtcttccagagcctctcatgacctatgagttacatggagatttcatt
gttccagccaaaagcggcagcccagaatctcgtgttaatgcgatccatttcttggtacac
aaactgccagagaagaataaagagatgttggatattttggtgaaacacttaacaaatgtt
tcaaatcactccaagcagaacctgatgactgtggcaaacttaggagtggtgtttggacca
actctgatgaggccacaggaagaaactgtcgctgccctcatggacttgaagtttcagaat
attgttgtggaaatcttaattgaaaaccatgaaaagatttttcggacgccgcccgatact
acattccctgagcccacctgcctgtcagcatcacccccaaatgcgccaccaaggcagtcg
aagagacaaggccagagaaccaagaggcccgtggccgtctacaatctttgtctggagctg
gaagatggtgacaatccttacccttccaaggaggacacccctaccagcagtctggactca
ctttcctccccgtctcccgtgactacagctgtccctgggcctcctggaccagacaaaaac
caccttctggcagatggagggagctttggagactgggcatccactatcccaggccagacc
cgatcgtctatggtccagtggcttaacccacagtctccaaccacaacaagctccaactca
gctgtgacacctctttcacccgggtcgtcccctttccccttttctcctcctgctactgta
gcggacaagccacctgaaagcatccgcagtcggaaggctcgagccgtgtatccgtgtgaa
gcagaacacagctcggaattatcttttgaaataggagcaatttttgaggatgtacaaacc
tccagggaacctggctggctagaagggactctgaacggcaagagggggctgattccacag
aactacgtcaagctgctgtag

Protein Sequence

>ARHGAP10
MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF
AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR
KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE
YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE
GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF
NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER
KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV
GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI
VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP
TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS
KRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKN
HLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV
ADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQ
NYVKLL

  • Gold
  • Silver
  • Bronze
  • IntAct