Field Data
UniProt Accession: A1L390
Gene Name: PLEKHG3
Gene Synonim: KIAA0599
GAP/GEF: GEF
Description: Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)
Keywords: Alternative splicing;Complete proteome;Methylation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 26030
Ensembl Gene ID: ENSG00000126822
Ensembl Protein ID: ENSP00000450945
Our Specificity Cdc42
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: actin
Localization in the literature: actin

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>PLEKHG3
atgcctgtgtccacctccctccaccaggatggcagccaggagcggccggtgagcctgacc
tctaccacctcctcgtcgggctcctcctgtgacagtcgcagtgccatggaggagcccagc
agctccgaggctcccgccaagaatggggcaggctccctgagaagccggcatctgcccaac
agcaacaacaactccagcagctggttgaacgtgaaggggcccctctccccgttcaacagc
cgggcagcggcagggcctgcacaccacaagctcagctacctgggccgagtggtgcgggag
atcgtggagacagagcgcatgtacgtacaggacctgcgcagcatcgtggaggactacctc
ttgaagatcattgacacacccgggctgctgaagccagaacaggtcagcgccctctttggg
aacatagaaaacatctacgcgctgaacagccagctcctcagagacctggacagctgcaat
agtgaccccgtggctgtggccagctgctttgtggaaaggagccaagagtttgatatctac
actcagtattgcaacaattaccccaactccgtggccgccctgacggaatgcatgcgggac
aagcagcaggccaagttctttcgggaccggcaggagctgctacagcactcgctgcccttg
ggctcctacctgctgaagccagtccagcgcatcctcaagtaccacctgctgctccaggaa
attgccaaacattttgatgaagaagaggatggctttgaggtggtggaggatgccattgac
accatgacctgtgtggcctggtacatcaacgacatgaagaggaggcatgagcacgcggtc
cggctccaggagattcagtcactcctcatcaactggaaggggcccgacctgaccacctac
ggggagcttgtcctggagggcacattccgcgtgcatcgcgtgcgcaatgaaaggaccttt
ttcctctttgacaaaacactgcttatcaccaagaagcggggcgatcactttgtctacaag
ggcaacatcccgtgctcctccctgatgctgatcgaaagcaccagagactccctgtgcttc
actgtcacccactacaagcacagcaagcagcagtacagcatccaggccaagacagtggag
gagaaacggaactggactcaccacatcaagaggctcatcctagagaaccaccatgccacc
attccccagaaggccaaggaagccatcttggaaatggattcctattatcccaatcggtac
cgctgcagcccagagcggctgaagaaggcttggtcctcccaggatgaggtgtccaccaat
gtgcgccaggggcgccggcaatctgagccaaccaaacacctgctcaggcaactcaacgag
aaagcccgagcagcaggaatgaagggaaaggggcgcagggagtctgaaagctccaggagc
agcagaaggcccagtggccggtctccaaccagtactgagaagcgcatgagcttcgagtcc
atttcttccctgccagaggttgagccggaccctgaggctgggagtgagcaagaggtattt
tctgctgtggaagggcccagtgccgaggagacgccttcagacacagaatctccagaagtc
ctggagacacagcttgatgcccaccagggccttctggggatggaccccccaggtgacatg
gtggacttcgtggcagctgagagcactgaggaccttaaggccctgagcagcgaggaggaa
gaagaaatgggaggtgccgcccaggagcctgagagccttctgccaccctccgtgctggac
caggccagcgtcattgcggagcgatttgtcagcagcttctctcggcggagcagcgtggca
caggaggacagcaagtccagtggctttgggagcccgcggctggtcagccggagcagcagc
gtgctcagcctggagggcagcgagaagggcctggcccggcatggcagtgccacagactcc
ctcagctgtcagctctccccagaagtggacatcagtgtgggggtggccacagaggacagc
ccttctgtcaatgggatggagcccccaagcccaggctgcccagtggagcctgaccggtct
tcctgcaagaagaaggaatcagcactctccacccgagaccggctgttgctagacaagatt
aagagctattatgaaaatgcagaacaccatgatgcaggcttcagcgtccgtcgccgggag
agcctctcctacatccccaaaggactggtaagaaactccatctccaggttcaacagcctt
ccccggccagacccagagccagtacctccagtggggagcaagagacaggtgggctcccgg
ccgacttcgtgggccctgtttgagctcccaggaccaagccaggcagtcaaaggggaccca
cctcccatctcagatgctgagttccgcccatcttcagaaattgtgaagatctgggaggga
atggagtcttccggagggagccctgggaaggggccaggccagggccaggccaatggcttt
gacctgcatgagccactcttcatcctggaggagcatgagctgggagccatcacagaggag
tcggccactgcctccccggaaagctcctctcccactgaggggcgcagcccggcccacctg
gcccgggagctgaaagagctggtgaaggagctgagcagcagtacccagggggagctggtg
gccccactgcacccccgcatcgtgcagctctcccacgtaatggacagccacgtgagcgag
cgcgtcaagaacaaggtctaccagctggcccgccagtacagcctccggatcaagagcaac
aagccagtgatggccaggccaccactgcagtgggaaaaggtggcccctgagagggatggg
aagagccccactgtgccctgtctacaggaagaggctggagagccattaggtggcaaaggt
aagaggaagccggtgctgtctctatttgactatgagcagctgatggcccaggagcacagc
cctcccaagccctcctcggctggggagatgtcaccacagcgtttcttcttcaacccgtct
gctgtcagccagaggaccacctcgcctgggggccggccctccgcccggagccccctcagc
cccacagagaccttcagctggcccgacgtccgtgagctctgctccaagtatgcctcccgc
gatgaggcacgccgagcagggggcggccggccccgcggcccacccgtcaacaggagccac
tcggtgccggagaacatggtagagccacctctgtcgggcagggtgggccgctgccgcagc
ctgagcaccaagaggggccggggaggcggagaggctgcccaatcccctgggcctctgccc
cagagcaagccggatggaggcgagaccctgtatgtcactgcagacctcaccctggaggac
aaccggcgggtgattgtcatggagaagggaccccttcccagccccactgcagggctggag
gagagcagtggccagggaccaagctcaccggtggccctgctggggcaggttcaggacttc
cagcagtctgcagagtgccagccgaaggaagagggttccagggacccggcagacccgagc
cagcagggcagagtgagaaaccttagagagaagttccaggccttgaactctgtcggtt

Protein Sequence

>PLEKHG3
MPVSTSLHQDGSQERPVSLTSTTSSSGSSCDSRSAMEEPSSSEAPAKNGAGSLRSRHLPN
SNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVEDYL
LKIIDTPGLLKPEQVSALFGNIENIYALNSQLLRDLDSCNSDPVAVASCFVERSQEFDIY
TQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILKYHLLLQE
IAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWKGPDLTTY
GELVLEGTFRVHRVRNERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLMLIESTRDSLCF
TVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKAKEAILEMDSYYPNRY
RCSPERLKKAWSSQDEVSTNVRQGRRQSEPTKHLLRQLNEKARAAGMKGKGRRESESSRS
SRRPSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTESPEV
LETQLDAHQGLLGMDPPGDMVDFVAAESTEDLKALSSEEEEEMGGAAQEPESLLPPSVLD
QASVIAERFVSSFSRRSSVAQEDSKSSGFGSPRLVSRSSSVLSLEGSEKGLARHGSATDS
LSCQLSPEVDISVGVATEDSPSVNGMEPPSPGCPVEPDRSSCKKKESALSTRDRLLLDKI
KSYYENAEHHDAGFSVRRRESLSYIPKGLVRNSISRFNSLPRPDPEPVPPVGSKRQVGSR
PTSWALFELPGPSQAVKGDPPPISDAEFRPSSEIVKIWEGMESSGGSPGKGPGQGQANGF
DLHEPLFILEEHELGAITEESATASPESSSPTEGRSPAHLARELKELVKELSSSTQGELV
APLHPRIVQLSHVMDSHVSERVKNKVYQLARQYSLRIKSNKPVMARPPLQWEKVAPERDG
KSPTVPCLQEEAGEPLGGKGKRKPVLSLFDYEQLMAQEHSPPKPSSAGEMSPQRFFFNPS
AVSQRTTSPGGRPSARSPLSPTETFSWPDVRELCSKYASRDEARRAGGGRPRGPPVNRSH
SVPENMVEPPLSGRVGRCRSLSTKRGRGGGEAAQSPGPLPQSKPDGGETLYVTADLTLED
NRRVIVMEKGPLPSPTAGLEESSGQGPSSPVALLGQVQDFQQSAECQPKEEGSRDPADPS
QQGRVRNLREKFQALNSVG

  • Gold
  • Silver
  • Bronze
  • IntAct