Field Data
UniProt Accession: A6NI28
Gene Name: ARHGAP42
Gene Synonim: GRAF3
GAP/GEF: GAP
Description: Rho GTPase-activating protein 42 (Rho GTPase-activating protein 10-like) (Rho-type GTPase-activating protein 42)
Keywords: Coiled coil;Complete proteome;GTPase activation;Phosphoprotein;Reference proteome;SH3 domain
Entrez ID: 143872
Ensembl Gene ID: ENSG00000165895
Ensembl Protein ID: ENSP00000298815
Our Specificity
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005575cellular_component

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0035024negative regulation of Rho protein signal transduction
GO:0003085negative regulation of systemic arterial blood pressure
GO:0090630activation of GTPase activity
GO:0007165signal transduction
GO:1904694negative regulation of vascular smooth muscle contraction

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: actin
Localization in the literature: actin

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP42
atggggctgcccactctggagttcagcgattcctacttggacagcccagatttcagggag
cgcttgcagtgtcacgagattgagctggagcgaaccaacaagttcatcaaggagctcatt
aaggacggctctctgctcattggggcgttgaggaatctgtctatggcagtgcagaaattt
tcccagtcattgcaagatttccagtttgaatgtattggtgatgctgaaacagatgatgaa
attagtattgctcagtcactaaaagaatttgcaagactactcattgcagtagaagaagaa
aggcgaagactgatccaaaacgctaatgatgtattaattgcaccacttgagaaatttcga
aaagaacagataggtgcagcaaaagatggaaagaagaagtttgacaaagagagtgaaaaa
tattactctatccttgaaaagcatttaaatttgtccgcaaagaaaaaggagtctcattta
caagaggcagatacacaaattgaccgagaacatcagaacttctatgaagcatcattagaa
tatgtctttaaaattcaagaggtccaagaaaaaaagaagtttgaatttgttgaaccgctt
ttgtcatttcttcagggcttatttactttttaccatgagggatatgaacttgcccaggaa
tttgcaccgtataagcaacagctgcagttcaacttgcagaatacaaggaataattttgaa
agtactcgacaagaggtagagcggttgatgcaaaggatgaaatctgccaaccaggactac
agaccacccagccagtggacgatggaaggctatctgtatgtccaggagaaacgaccgctt
ggttttacatggattaaacattattgtacatatgataagggaagtaaaacatttacaatg
agtgtttcagaaatgaaatccagtgggaaaatgaatggccttgttactagctcaccggaa
atgtttaaattaaaatcttgtatccgacgaaagacagattcaattgacaaacgattctgc
tttgacatagaagtagttgaaaggcatgggatcatcacgttacaggccttctcagaagct
aataggaaactctggcttgaagccatggatgggaaggaaccgatttatactctgcctgcc
attataagcaagaaagaagaaatgtatttgaatgaagcagggttcaactttgtgagaaaa
tgcattcaagctgtggaaacaagaggtatcaccattttaggactctaccgaataggagga
gtgaactccaaagttcaaaaactcatgaataccacattttctcctaaatcccctcctgat
attgatattgatattgaactgtgggacaataagacgataacaagtgggctgaaaaactac
ctcaggtgccttgcagaaccactgatgacttacaagttgcacaaagattttatcattgct
gttaaatctgatgaccaaaactacagggtggaggctgtacatgcattggtgcacaaattg
ccggagaaaaacagagagatgctggacatcttaataaagcatctggtcaaagtatcacta
cacagccaacaaaatctcatgactgtctcaaatcttggtgtcatatttggcccaactcta
atgagagcacaggaagaaactgtggctgctatgatgaatattaaatttcagaatattgtg
gtagaaattctgatagagcactatgaaaagatttttcatactgctccagacccaagcatt
cctcttcctcagcctcagtctcgatctggatcccgaaggacgcgagcaatctgcctctct
acagggtctaggaagcccagagggaggtatactccatgcctggctgaacctgatagtgac
tcctatagcagcagcccagacagcacacctatggggagcattgagtcactctcttctcat
tcctctgaacaaaatagcactacaaagtcagcttcctgccagcccagggagaaatctgga
gggattccttggattgcaaccccgtcatcttccaatggacagaaaagccttggtctctgg
acaactagtcctgaatcaagttccagagaagatgcgaccaagacagatgcagaatcagac
tgccagagtgttgcttcggtcactagcccaggagacgtttccccacccatagacctagtc
aagaaagagccttatgggctttcaggactgaaaagagcttctgcttcttctctcagatcc
atctctgcagctgaaggaaacaagagctacagtggatctattcaaagcttaacttctgta
ggttccaaggagacacccaaagcttcaccaaacccagacctgcctccgaaaatgtgcagg
agattaagactagacactgcctcaagcaatggctatcagcgtcctggctcagtagtggca
gcaaaagctcaactgtttgaaaatgttggttcacctaaaccagtttcttctgggcgccaa
gccaaagccatgtactcctgtaaagcagagcacagtcatgagctttccttcccacaagga
gcgatattttctaatgtgtacccatcagtggaaccaggatggttaaaggcaacttatgaa
ggcaaaacaggactagttccagaaaattatgttgtcttcctcttaatta

Protein Sequence

>ARHGAP42
MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF
SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR
KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE
YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE
STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM
SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA
NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG
VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA
VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL
MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS
TGSRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSG
GIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLV
KKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCR
RLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHELSFPQG
AIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFLLI

  • Gold
  • Silver
  • Bronze
  • IntAct