Field Data
UniProt Accession: A7KAX9
Gene Name: ARHGAP32
Gene Synonim: GRIT, KIAA0712, RICS
GAP/GEF: GAP
Description: Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)
Keywords: 3D-structure;Alternative splicing;Cell junction;Cell membrane;Cell projection;Complete proteome;Cytoplasm;Endoplasmic reticulum;Endosome;GTPase activation;Golgi apparatus;Membrane;Methylation;Phosphoprotein;Postsynaptic cell membrane;Reference proteome;SH3 domain;Synapse
Entrez ID: 9743
Ensembl Gene ID: ENSG00000134909
Ensembl Protein ID: ENSP00000432862
Our Specificity
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005654nucleoplasm
GO:0042995cell projection
GO:0005783endoplasmic reticulum
GO:0043197dendritic spine
GO:0005794Golgi apparatus
GO:0015629actin cytoskeleton
GO:0005829cytosol
GO:0016020membrane
GO:0000139Golgi membrane
GO:0001650fibrillar center
GO:0045211postsynaptic membrane
GO:0014069postsynaptic density
GO:0005938cell cortex
GO:0005886plasma membrane
GO:0045202synapse
GO:0005789endoplasmic reticulum membrane
GO:0005768endosome
GO:0030054cell junction
GO:0010008endosome membrane

Molecular Function

GO ID Description
GO:0035091phosphatidylinositol binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007264small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: plasma_membrane, puncta
Localization in the literature: vesicles, Golgi, endoplasmic reticulum

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP32
atggagactgaaagtgagagtagcactttaggggatgacagtgtcttctggttggagtct
gaagttataatccaggtgactgactgtgaagaggaagaaagggaagagaagttcaggaag
atgaagtcctcagtacattctgaagaagatgattttgttccagagctacatagaaatgta
caccctcgagagcggcctgattgggaagaaactcttagcgcaatggcaagaggcgcagat
gttccagagattcctggagatcttactcttaagacgtgtggcagtacagccagtatgaag
gttaagcatgtgaaaaagttacccttcactaaaggtcactttccgaagatggctgaatgt
gcgcatttccattatgagaatgttgagttcggcagcatacagctttcactttcagaagaa
cagaatgaagtaatgaaaaatggctgtgaatctaaagagctggtctacctcgtgcagatt
gcttgtcagggaaaaagttggattgttaaaagaagttatgaagattttcgggtacttgat
aaacatcttcatctgtgtatttatgaccgaagattttcccagctctcagaacttccccgt
tctgacaccctgaaggacagtccagagtcggtcactcagatgcttatggcttacctgtca
cgcctttcagctatcgctggcaacaagatcaactgtgggcccgcccttacctggatggag
attgataataagggaaatcaccttttggttcatgaggagtcatccatcaacactcctgct
gtcggtgctgcccatgttatcaagaggtacactgctcgggcccctgacgaactgacctta
gaggtgggagacattgtttctgttattgacatgcccccgaaagtgttaagcacatggtgg
agaggcaagcacggattccaggtgggactcttccctggacactgtgttgagttgattaac
caaaaagttccccagtcagtgaccaactcagtgccaaaaccagtgtctaaaaagcacggc
aagctcattacgttcttacgaacattcatgaagtctcgtccaacaaaacagaagctgaag
cagcggggaatcttgaaagagagggtgtttggttgtgacctgggggaacaccttctaaat
tctggttttgaagtgccgcaggttcttcaaagctgcacagcattcattgagagatatggc
atcgtggatggaatctatcgcctttctggtgttgcctccaatatccagagactacgccat
gaatttgactctgagcacgtccccgacctgacgaaagaaccgtatgttcaggacatccat
tctgtgggttccctatgtaagctgtacttccgggaactcccaaaccctctgcttacctac
cagctgtatgagaaattttctgatgcagtttcagcagcaacagatgaagaaaggctgata
aaaatccacgatgtcatccagcagctccccccaccacactacagaacactggagttcctg
atgagacacttgtctcttctagctgactattgttccatcacaaatatgcatgcaaaaaat
ctagcaattgtttgggctccaaacctgttaagatcaaaacagatagaatctgcctgcttc
agtggaacagcagctttcatggaagtgaggattcagtctgtggttgttgagttcatcctg
aatcacgttgatgtgctgttcagcggcagaatcagcatggccatgcaagagggggcagct
tctctatcaaggcccaagtccctcctggtatcctctccatccaccaaactgctgacattg
gaagaggcccaggcacgaacacaagctcaggtcaattctccaattgtgacggaaaataaa
tatatcgaagtaggagaaggacctgctgcacttcaggggaaatttcataccataattgag
ttcccacttgaaagaaagaggcctcaaaataagatgaaaaagtctcctgtgggtagctgg
cgttcctttttcaacttggggaaatcatcatctgtttctaaacgaaagctgcagcggaat
gagagtgagccttcagagatgaaagccatggctctgaaaggtggcagggcagaaggaacc
ctccgttcagctaaaagtgaggagtctcttacatctctccatgcagttgatggtgattct
aagctcttccgacccagaagacccagatcttccagtgatgcactgtctgcctcttttaat
ggagaaatgctggggaaccgctgtaactcctatgataatctgcctcatgacaatgagagt
gaggaggaaggagggctgcttcatatcccagcccttatgtctcctcattcagctgaggat
gttgacttgagcccaccagacattggagtagccagcctggattttgatccaatgtcattt
caatgtagtcctcctaaggccgaatcagaatgtctggagagtggtgcttcctttttagat
tcaccaggatactccaaggataaaccaagtgccaataaaaaggatgcagaaacaggtagt
agccaatgtcagactccaggaagcacagcaagctctgaacctgtctctcctcttcaggag
aaactgagtccattctttaccctggacttgagcccaactgaagataaatcatctaagcca
tcctcctttactgaaaaggtcgtctatgctttctctccgaagataggacggaaattaagc
aaatcaccttctatgagcatatctgagccaatttcagtgaccctaccaccacgggtgtca
gaagtcattggtacagtctcaaataccacagctcagaatgcatcatcttcaacctgggac
aaatgcgttgaagaaagggatgccacaaatagatcccccacccagatagtaaagatgaaa
acaaatgagacagttgcccaagaagcatatgaatctgaagtccagcccctggaccaggtg
gctgctgaagaagtagaattgccagggaaagaggatcagtctgtctcaagcagtcagagt
aaggctgtagcttctggacagactcagacaggagcagttacccatgacccccctcaggat
tccgttcctgtcagttcagtctctcttatcccaccaccaccgcctccgaaaaatgttgcc
cgaatgttggcgctagcattagctgagtccgcacagcaagcctcaactcagtcattgaag
agaccagggacctctcaggctgggtatacaaattatggagacatagcggtggctacaact
gaagataatctgtccagttcttactctgcagttgctctagataaggcctatttccaaacc
gatcgaccagcagagcagttccacctccagaataatgcaccaggaaactgtgaccatcct
ctaccagagacaacagctactggggatcctacccattccaacacaactgaatctggggag
caacatcaccaagtagacttaacagggaatcagccacatcaagcatatttatctggggac
ccagaaaaggccagaattacttcagttcccttagactcagagaagtctgatgatcatgta
agtttccctgaagaccagtctgggaagaacagtatgccaactgtctccttcttggatcag
gaccagtctccaccccgtttctacagtggagatcagcctccttcttatcttggtgcaagt
gtggataaactccatcaccctttagaatttgcagacaaatctcccacacctcctaattta
cctagcgataaaatctaccctccttctgggtcccccgaagagaataccagcacagccacc
atgacttacatgacaactactccagcaacagcccaaatgagcaccaaggaagccagctgg
gatgtggctgaacaacccaccactgctgattttgctgctgccacacttcagcgcacgcac
agaactaatcgtccccttccccctccgccttcccagagatctgcagagcagccaccagtt
gtggggcaggtacaagcagcaaccaatataggattaaataattcccacaaggttcaagga
gtagttccagttccagagaggccacctgaacctcgagccatggatgaccctgcgtctgcc
ttcatcagtgacagtggtgctgctgctgctcagtgtcccatggctacagctgtccagcca
ggcctgcctgagaaagtgcgggacggtgcccgggtcccgctgctgcacctgcgcgccgag
tctgtccctgcgcatccctgtggctttcctgcaccactgccccccaccaggatgatggag
agtaagatgattgctgccatacactccagcagtgcagatgccaccagcagttcaaattat
cattcctttgtcactgcttcatccacctctgtggacgatgcattgcctttaccacttcct
gtcccacaacctaagcatgcttctcagaaaacagtttactcctcctttgctaggcccgat
gtcaccactgaaccctttggtccagataactgtttgcatttcaatatgactccaaactgc
cagtaccgtccccagagtgtacctccccatcacaataaattggagcagcaccaagtgtat
ggtgccaggtcagagccaccagcctccatgggtcttcgttataacacatatgtggcccca
ggaagaaacgcatctggacaccactccaagccatgcagccgggtcgagtatgtgtcttct
ttgagctcctctgtcaggaatacctgttaccccgaagacattccaccgtaccctaccatc
cggagagtgcagtctctccatgctccgccgtcttccatgattcgctctgttcccatttca
cggacagaagttcccccagatgatgagccagcctactgcccaagacctctgtaccaatat
aagccatatcagtcctcccaggcccgctcagattatcatgtcactcagcttcagccttac
tttgagaatggccgggtccactacaggtatagcccatattccagttcttctagttcctat
tacagtccagatggggccctgtgtgatgtggatgcctatggcacagtccagttgagaccc
cttcaccgccttcccaatcgagactttgctttctacaatcctaggctgcaaggaaagagc
ttgtacagttatgctggtttggctccacgtccccgggccaacgtgactggctatttctct
cccaacgaccataatgtagtcagcatgcctccggctgctgatgtgaagcacacctacacc
tcatgggatcttgaggacatggaaaaataccgcatgcagtccatccggagagagagccgt
gctcggcagaaggtgaaagggcctgtcatgtcccaatatgataacatgaccccggcggtg
caggacgacttgggtgggatctatgtcatccatctgcgtagtaaatcagatcctgggaaa
actggacttctctcagtggcagaaggaaaggagagccgccatgcagccaaggccatcagt
cccgagggagaggaccgcttctataggaggcatcccgaggcagagatggacagagcccac
catcacggaggccatggtagcacgcagccggagaagccatccctgcctcagaagcagagc
agcctgaggagcaggaagcttcctgacatgggctgcagtcttcctgagcacagggcacac
caagaagcaagccataggcagttctgtgagtcaaagaatgggcccccttatccccaggga
gctggccagttagattatgggtccaaagggattccagacacttctgagccagtcagctac
cacaactctggagtaaaatatgctgcatccgggcaagaatctttaagactgaaccacaaa
gaggtaaggctctccaaagagatggagcgaccctgggttaggcagccttctgccccagag
aaacactccagagactgctacaaggaggaagaacacctcactcagtcaatcgtcccaccc
cctaaaccagagaggagtcatagcctcaaactccatcatacccagaacgtggagagggac
cccagtgtgctgtaccagtaccaaccacacggcaagcgccagagcagtgtgactgttgtg
tcccagtatgataacctggaagattaccactccctgcctcagcaccagcgaggagtcttt
ggagggggcggcatggggacgtatgtgccccctggctttccccatccacagagcaggacc
tatgctacagcgttgggtcaaggggccttcctgcccgcagagttgtccttgcagcatcct
gaaacacagatccatgcagaattaatta

Protein Sequence

>ARHGAP32
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNV
HPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAEC
AHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLD
KHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWME
IDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWW
RGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLK
QRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRH
EFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLI
KIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACF
SGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTL
EEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSW
RSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDS
KLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAED
VDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGS
SQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLS
KSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMK
TNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQD
SVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATT
EDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGE
QHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQ
DQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTAT
MTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPV
VGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQP
GLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNY
HSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNC
QYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSS
LSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQY
KPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRP
LHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYT
SWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGK
TGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQS
SLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSY
HNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPP
PKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVF
GGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAELI

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