Field Data
UniProt Accession: B2RTY4
Gene Name: MYO9A
Gene Synonim: MYR7
GAP/GEF: GAP
Description: Unconventional myosin-IXa (Unconventional myosin-9a)
Keywords: ATP-binding;Actin-binding;Alternative splicing;Coiled coil;Complete proteome;GTPase activation;Membrane;Metal-binding;Motor protein;Myosin;Nucleotide-binding;Phosphoprotein;Polymorphism;Reference proteome;Repeat;Transmembrane;Transmembrane helix;Zinc;Zinc-finger
Entrez ID: 4649
Ensembl Gene ID: ENSG00000066933
Ensembl Protein ID: ENSP00000398250
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0016459myosin complex
GO:0005829cytosol
GO:0016020membrane
GO:0016021integral component of membrane
GO:0016461unconventional myosin complex

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0000166nucleotide binding
GO:0003779actin binding
GO:0005515protein binding
GO:0046872metal ion binding
GO:0003774motor activity
GO:0005524ATP binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0045198establishment of epithelial cell apical/basal polarity
GO:0043547positive regulation of GTPase activity
GO:0007601visual perception
GO:0007165signal transduction
GO:0035556intracellular signal transduction
GO:0034329cell junction assembly

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: actin
Localization in the literature: plasma membrane (junctions)

Confocal Images

Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>MYO9A
atgaatataaatgatggaggaagacgacgctttgaagataatgaacatacattacggata
tatcctggggctatttcagaagggacaatctactgtccgattcctgccagaaaaaactcc
acagctgctgaggtgattgagtctcttataaacaaacttcatcttgacaaaacaaaatgt
tatgttctagcagaggtaaaggaatttggtggagaagaatggattctcaatccaacagat
tgtccagttcagcgaatgatgctgtggccccgaatggctctggaaaatcgcttaagtgga
gaggactaccgcttccttctgagagagaaaaaccttgatggatcaatccattatggtagc
ctgcagtcatggctacgggtaacagaagaacgtcgcaggatgatggaacggggttttctt
ccacagcctcaacagaaagactttgatgatttatgtagtttacctgatttgaatgagaaa
actctcttagaaaacctacgaaatcgctttaagcatgaaaaaatttatacctatgttggc
agtattctaatagttattaacccattcaagtttcttcctatttataaccccaaatatgtc
aaaatgtatgataaccaccaactgggaaaacttgagccccacatttatgctgtggctgat
gtagcttatcatgccatgcttcagcgcaaaaagaatcagtgcatcgtgatttcaggagag
agtggttctgggaagactcaaagcacaaactttcttattcaccaccttactgctctcagt
cagaaaggatttgccagtggagtagaacagattattcttggagctggaccagtacttgag
gcctttggaaatgcaaagacagctcataataacaattcaagtcgttttgggaagtttatt
caagtaaattaccaggaaacaggcactgtacttggtgcctatgttgaaaaatatctactg
gagaagtccagactcgtttatcaggagcataatgaacggaactatcatgtattctattac
ctcctggcaggagcaagtgaagatgagagatcagcattccatcttaagcaaccagaggaa
tatcattatctcaatcagataacaaagaaacccctcagacagagctgggatgattattgc
tatgactctgagccggattgcttcacggtggaaggagaagatttgagacatgactttgag
cgcctacaacttgccatggaaatggtaggatttcttcccaagacacgaagacagattttc
tctcttctctcagccatactacatttgggtaatatctgttacaaaaagaagacataccgg
gatgactccattgatatctgtaatcctgaagttctgcctattgtctcagaattattagag
gttaaagaagagatgctatttgaagcattagttacaaggaagacggtgacagtgggagaa
aagcttattttgccatacaagttggcagaggctgtgacagtgaggaactccatggctaag
tctctgtatagtgccctgtttgactggatagtttttcgaattaatcatgcacttctgaat
agtaaagatttagagcataataccaagacattgtctattggtgttcttgatatttttggg
tttgaagattatgaaaataacagctttgaacagttctgtattaattttgctaatgaacgt
ttacagcactactttaatcagcatatctttaaattggaacaagaggaatatagaactgaa
ggtatcagctggcacaacatagattacattgataatacctgctgcataaatcttattagc
aaaaaaccaacaggactgcttcatcttttggatgaagaaagcaactttccacaggctaca
aatcaaacattgctagacaagtttaagcatcaacatgaagataattcttacatcgaattt
ccagccgtgatggagcctgctttcattataaaacattatgctggaaaagtaaaatatggg
gtaaaggatttccgggaaaaaaatacagatcatatgcgcccagacattgtagctcttctg
agaagcagcaagaatgcatttatctctgggatgattggaattgatcctgtagctgttttc
cgatgggcaattctccgagcttttttcagagccatggttgctttcagggaagctgggaaa
agaaacattcacagaaaaactggacatgatgatacagcgccatgtgcaattttgaaaagt
atggatagttttagctttctccaacacccagtccaccagaggagcttagagattctgcag
agatgcaaggaagagaagtacagtataacccggaaaaatcccagaacacctctttctgat
ctccagggcatgaatgctctaaatgaaaaaaaccaacatgatacatttgatattgcctgg
aatggcagaactgggattcgccagagcagactatcaagtggcacctccttgcttgataaa
gatggaatatttgctaattcaactagcagcaaactcctggagagagcccatggaattctc
acgagaaacaaaaatttcaaatccaagcctgcccttccaaagcacttgctagaagtaaat
tctttaaagcacctgacaagactgacactacaagatcgcattaccaagtctcttcttcat
ttacacaagaagaaaaaacctcccagcatcagtgcccagtttcaggcatcattaagcaag
ctaatggaaacacttggtcaagcagaaccatattttgtaaaatgcattcgctctaatgct
gaaaagctgcccttaaggttcagtgatgtcttggtacttagacagcttcgatacaccggg
atgctggaaacagttcgaattcgccaatcaggatacagctccaaatattctttccaggat
tttgtgagccacttccatgtacttcttccccgaaatattattccatccaaatttaacatt
caggatttcttcaggaaaataaatcttaatccagataattatcaagttggaaaaaccatg
gtctttctaaaggagcaggaacgacagcacttacaagatctgcttcaccaagaggtgctc
cgcagaatcatattgttgcagcgatggttcagggtcttgctgtgtaggcagcatttcctc
catctgagacaagcatctgttattatccagagattctggaggaattacctaaatcagaag
caagtcagagatgcagctgtgcagaaggatgcttttgttatggctagtgcagctgctctt
ctccaagcttcctggcgtgctcacttagagaggcagcggtacttggagttacgggctgca
gccatcgttatccagcagaaatggagagattactataggcgcaggcacatggctgctatt
tgcatacaagcaagatggaaagcctacagggaaagtaaaaggtaccaagaacaaaggaaa
aaaattatccttttgcaatcaacatgtagaggattcagagcaagacaaagatttaaagct
ttaaaagaacaaaggctaagagaaacaaagccagaagttggattggtgaatattaaggga
tatggatctctggaaattcagggttcagacccttcagaatgggaggattgttcttttgac
aacagaataaaagccatagaggaatgtaaatctgtaatagagagtaatcgaattagccgt
gaaagttcagtggactgcttgaaggagtcaccaaacaagcagcaggagagagcccaaagc
cagagtggtgtggacttgcaggaagatgtgcttgtaagagagagacccaggtccttggag
gatctccatcagaaaaaagtaggccgggctaagagagaaagtaggagaatgagagaacta
gagcaagctatatttagcttagaattgctgaaagttcgttctcttggtggtatttctcct
tcagaggatcgcagatggtctacagaattggtgcctgaaggccttcagtctccacggggt
acacctgatagtgagagctctcaaggaagcttggaacttctgagctatgaggaaagccaa
aagagcaaactagagtctgtcatttcagatgaaggagacttgcagtttccatcacctaag
atatccagcagtccaaaatttgattcacgggacaatgccctcagtgcctcaaatgagact
agcagtgcagagcatttgaaggatggaactatgaaggaaatggtggtctgcagttctgag
tctattacctgtaaaccacagctgaaagactccttcatttcaaatagtctacctactttt
ttttatatcccccaacaagacccactgaaaacaaattcccaactagacacaagtatccaa
agaaacaaactattggaaaatgaagacacagcgggggaagctcttactttggatatcaac
agggaaactagaaggtatcactgctcaggaaaagatcagattgttccttctttgaataca
gagtcttctaatcctgtgcttaagaagttagaaaagctaaacactgagaaggaagaaagg
caaaaacagttgcagcaacagaatgaaaaagagatgatggaacagattcgccagcaaaca
gatattttagagaaggagcgcaaagccttcaagacaattgaaaagccaagaattggagag
tgtttggtggcaccatcttcctatcagtcaaagcaaagagtagagaggccatcctctctc
ctcagcttaaatacctcaaataagggagaacttaatgtactggggtccctatcattaaaa
gatgcagctcttgcccaaaaagacagttcctctgctcacttacccccaaaggaccgacct
gtcaccgtgttctttgaaagaaaaggaagtccatgccaatctagtactgtcaaggaatta
tccaagacagacagaatgggcacccagctgaatgtagcctgtaaactctcaaataatcgc
atttcaaaaagagaacactttaggccaactcagtcttacagccacaattctgatgacctt
tccagagagggaaatgctaggcccattttcttcactccaaaggacaatatgagtattccc
cttgtcagcaaagaagccttaaacagtaaaaatcctcaactccataaagaagatgaacca
gcatggaaacctgtgaagttagctgggccaggccaaagagagacatcacagcgattttcg
tcagttgatgaacaagcaaaacttcataagactatgtctcaaggagagattaccaagttg
gcagtgagacagaaggcttcagattcagatataagacctcagagagctaagatgagattc
tgggccaaagggaaacaaggggagaagaagactaccagagtgaaacctactacccagtca
gaggtttcgccactctttgcaggcacagatgtgattccagctcatcagtttccagatgaa
ttagctgcatatcacccaacacctcctttgagcccagaactgcccggcagttgccggaag
gaattcaaagagaacaaagaaccttctccaaaggctaagcgcaagcgaagtgtgaagatt
agcaacgtggctttggattctatgcattggcaaaatgactctgtccagatcatagcaagt
gtcagtgatttaaaaagcatggatgaatttcttctgaaaaaggtgaatgacctagataat
gaagacagcaagaaggatacactagtggatgttgtatttaaaaaagccctgaaggaattt
cggcagaatatcttcagcttttattcatctgcattggcgatggatgatgggaaaagcata
cggtataaagacctctatgcactatttgaacagattctggaaaagacgatgaggcttgag
cagcgtgattcactgggtgaatctccagtgagagtttgggtcaacacttttaaagtgttt
ttagatgaatatatgaatgaattcaagacttcagattgcacagccacaaaggtgccaaaa
acagaaagaaagaaaagaaggaaaaaggaaactgatttggtggaagaacacaatggtcac
atctttaaagccacccaatatagcatccctacatactgtgaatactgttcttctttgata
tggataatggaccgagcctctgtttgcaaattatgcaagtatgcttgccataagaagtgc
tgtctgaaaaccacagccaagtgctctaaaaagtatgatccagagctgtcatctcgacaa
tttggggttgaactgtcccgtttgaccagtgaagaccgaactgttcctttagtagtggaa
aagctcataaactacattgaaatgcatggactgtatacagaaggtatttatcgaaagtct
ggttcgactaataaaatcaaggagcttcggcagggtctagatacagatgctgagagtgta
aatctagatgactataacatacacgtcattgcaagtgtattcaaacaatggcttcgagat
ttgcccaatcctctcatgacctttgaactctatgaggaatttcttcgagctatgggcctt
caggagaggaaggagacaatccgtggtgtatactctgtgattgatcaactctcccgaact
catctcaatacactggaacgcctcatctttcatctagtcaggattgctctgcaggaagac
actaatcgaatgtctgctaatgctttggccattgtgtttgcgccctgcattctccgctgc
cctgacaccactgacccactacaaagtgtacaggacatcagtaagactaccacttgtgtg
gaactgattgttgtggaacaaatgaataaatacaaggctcgtctcaaagatatcagtagc
ttggaatttgctgagaataaggcaaagaccaggttgtcactgattcgtagatcaatggga
aaggggcgtattcgtcgaggaaactatccaggtccatcgtctcctgttgtagttcggttg
ccttctgtgtctgatgtctcagaggagaccttgactagtgaggcagccatggagactgac
atcacagaacagcagcaagcagctatgcagcaggaggagagagtactgactgagcagatt
gagaacctacagaaggagaaggaggagctaacatttgagatgcttgtactggaaccccgt
gcctctgatgatgaaacccttgagtctgaggcctccattgggactgctgatagctcagag
aatttgaatatggagtctgaatatgctatctctgagaaatcagaaagaagcttagccctt
agctccctgaagacagctggcaagtctgaaccttccagcaagttgcgaaagcaacttaaa
aagcagcaagactctttagatgtcgtggactcttcggtctcctctttatgtctgtctaac
acggcatcatctcatgggaccagaaaactatttcagatttattccaaatctccattctac
cgagctgcctcaggtaatgaggccctgggaatggaaggaccattgggccagaccaaattc
ctggaagacaagcctcagttcatcagcagaggaaccttcaacccggaaaagggcaaacaa
aaattaaagaatgtgaaaaactcacctcagaaaaccaaagagaccccagaggggacagtc
atgtctggccgcagaaaaactgtggacccagactgcacctccaaccaacagctagcactc
tttggaaataatgaatttatggtcttaatta

Protein Sequence

>MYO9A
MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKC
YVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGS
LQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVG
SILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGE
SGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFI
QVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEE
YHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIF
SLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGE
KLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFG
FEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLIS
KKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYG
VKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGK
RNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSD
LQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGIL
TRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSK
LMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQD
FVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVL
RRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAAL
LQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRK
KIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSEWEDCSFD
NRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLE
DLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRG
TPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNET
SSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQ
RNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEER
QKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSL
LSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKEL
SKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIP
LVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKL
AVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDE
LAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIAS
VSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSI
RYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPK
TERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKC
CLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKS
GSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGL
QERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRC
PDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMG
KGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQI
ENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLAL
SSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFY
RAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTV
MSGRRKTVDPDCTSNQQLALFGNNEFMVLI

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