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Cellular Component

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GO ID	Description
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005942	phosphatidylinositol 3-kinase complex

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Molecular Function

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GO ID	Description
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0030971	receptor tyrosine kinase binding
GO:0005096	GTPase activator activity
GO:0019903	protein phosphatase binding
GO:0035014	phosphatidylinositol 3-kinase regulator activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity
GO:0001784	phosphotyrosine residue binding

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Biological Process

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GO ID	Description
GO:0001678	cellular glucose homeostasis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0007165	signal transduction
GO:0032869	cellular response to insulin stimulus
GO:0043409	negative regulation of MAPK cascade
GO:0043547	positive regulation of GTPase activity
GO:0046854	phosphatidylinositol phosphorylation
GO:0006661	phosphatidylinositol biosynthetic process
GO:0010506	regulation of autophagy
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0008286	insulin receptor signaling pathway
GO:0038111	interleukin-7-mediated signaling pathway
GO:0006810	transport
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0048015	phosphatidylinositol-mediated signaling
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2001275	positive regulation of glucose import in response to insulin stimulus
GO:0015031	protein transport
GO:0034976	response to endoplasmic reticulum stress

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Reactome

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Reactome ID	Description
R-HSA-1660499	Synthesis of PIPs at the plasma membrane
R-HSA-198203	PI3K/AKT activation
R-HSA-4420097	VEGFA-VEGFR2 Pathway
R-HSA-114604	GPVI-mediated activation cascade
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-186763	Downstream signal transduction
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-1266695	Interleukin-7 signaling
R-HSA-1257604	PIP3 activates AKT signaling
R-HSA-8853659	RET signaling
R-HSA-389357	CD28 dependent PI3K/Akt signaling
R-HSA-194840	Rho GTPase cycle
R-HSA-388841	Costimulation by the CD28 family
R-HSA-2029485	Role of phospholipids in phagocytosis
R-HSA-202424	Downstream TCR signaling
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-912526	Interleukin receptor SHC signaling
R-HSA-1433557	Signaling by SCF-KIT
R-HSA-392451	G beta:gamma signalling through PI3Kgamma
R-HSA-2424491	DAP12 signaling
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling
R-HSA-912631	Regulation of signaling by CBL
R-HSA-416476	G alpha (q) signalling events
R-HSA-109704	PI3K Cascade
R-HSA-210993	Tie2 Signaling
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-373753	Nephrin family interactions

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KEGG

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Kegg ID	Description
hsa04152	AMPK signaling pathway
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04611	Platelet activation
hsa04510	Focal adhesion
hsa04923	Regulation of lipolysis in adipocytes
hsa05212	Pancreatic cancer
hsa04650	Natural killer cell mediated cytotoxicity
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05218	Melanoma
hsa04024	cAMP signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa05418	Fluid shear stress and atherosclerosis
hsa04140	Autophagy - animal
hsa04670	Leukocyte transendothelial migration
hsa04725	Cholinergic synapse
hsa05231	Choline metabolism in cancer
hsa04068	FoxO signaling pathway
hsa04380	Osteoclast differentiation
hsa04066	HIF-1 signaling pathway
hsa04926	Relaxin signaling pathway
hsa04150	mTOR signaling pathway
hsa04062	Chemokine signaling pathway
hsa04960	Aldosterone-regulated sodium reabsorption
hsa04370	VEGF signaling pathway
hsa01521	EGFR tyrosine kinase inhibitor resistance
hsa01522	Endocrine resistance
hsa01524	Platinum drug resistance
hsa04914	Progesterone-mediated oocyte maturation
hsa05142	Chagas disease (American trypanosomiasis)
hsa04218	Cellular senescence
hsa05166	HTLV-I infection
hsa05146	Amoebiasis
hsa05169	Epstein-Barr virus infection
hsa05213	Endometrial cancer
hsa04211	Longevity regulating pathway
hsa04210	Apoptosis
hsa04213	Longevity regulating pathway - multiple species
hsa04810	Regulation of actin cytoskeleton
hsa04015	Rap1 signaling pathway
hsa05161	Hepatitis B
hsa05162	Measles
hsa04662	B cell receptor signaling pathway
hsa04917	Prolactin signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04072	Phospholipase D signaling pathway
hsa05100	Bacterial invasion of epithelial cells
hsa04973	Carbohydrate digestion and absorption
hsa05205	Proteoglycans in cancer
hsa04915	Estrogen signaling pathway
hsa05206	MicroRNAs in cancer
hsa04620	Toll-like receptor signaling pathway
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa04071	Sphingolipid signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa04910	Insulin signaling pathway
hsa05224	Breast cancer
hsa04750	Inflammatory mediator regulation of TRP channels
hsa05222	Small cell lung cancer
hsa05221	Acute myeloid leukemia
hsa05220	Chronic myeloid leukemia
hsa04668	TNF signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04930	Type II diabetes mellitus
hsa04931	Insulin resistance
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa04660	T cell receptor signaling pathway
hsa05167	Kaposi's sarcoma-associated herpesvirus infection
hsa05215	Prostate cancer
hsa05226	Gastric cancer
hsa05223	Non-small cell lung cancer
hsa05160	Hepatitis C
hsa05164	Influenza A
hsa05225	Hepatocellular carcinoma
hsa04014	Ras signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05165	Human papillomavirus infection
hsa04360	Axon guidance
hsa05230	Central carbon metabolism in cancer
hsa05214	Glioma
hsa04664	Fc epsilon RI signaling pathway
hsa04012	ErbB signaling pathway

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Field	Data
Localization in this study:	focal_adhesions
Localization in the literature: