Field Data
UniProt Accession: O14559
Gene Name: ARHGAP33
Gene Synonim: SNX26, TCGAP
GAP/GEF: GAP
Description: Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Methylation;Phosphoprotein;Protein transport;Reference proteome;SH3 domain;Transport
Entrez ID: 115703
Ensembl Gene ID: ENSG00000004777
Ensembl Protein ID: ENSP00000368227
Our Specificity Rac1
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0043234protein complex
GO:0015629actin cytoskeleton
GO:0005829cytosol
GO:0005938cell cortex
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0019901protein kinase binding
GO:0035091phosphatidylinositol binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0006810transport
GO:0007165signal transduction
GO:0015031protein transport
GO:0007264small GTPase mediated signal transduction

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: actin, basal_membrane_filaments, plasma_membrane
Localization in the literature: cytosolic

Confocal Images

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ARHGAP33
atgctccaggcacagaaacagtcagatcccatcctgccttggggagcttcatgggctggc
aggggacagactctgagggcccgcagcactgacagcctggatggcccaggggagggctca
gtgcagcccgtacccactactggggggccgggtacaaaggggaagcctgggaagaggctc
tcagctcctcgaggccctttcccccggctggctgactgtgcccatttccactatgagaat
gttgactttggccacattcagctcctgctgtctccagagcgtgagggccccagcctctct
ggagaaaatgagctggtctttggggtacaggtgacctgtcagggccgctcctggccagtc
ctccggagctatgacgatttccgttctctggatgcccatctccaccggtgcatatttgac
cggagattttcctgcctcccagagctccctccacctccagagggtaccagggctgcccag
atgctggtaccgctgctgctgcagtacctggagaccctgtcaggactggtggacagtaac
ctcaactgtggacctgtgctcacttggatggagctggacaaccatggccggcgcctgctc
ctcagtgaggaagcctccctcaatatccctgctgtggctgctgcccacgtggtcaagcgg
tacactgcccaggcgccagatgagctgtcctttgaggtgggagacattgtctcagtgatc
gacatgccacctacagaggatcggagctggtggcggggcaaacggggcttccaggttggt
ttcttccccagtgagtgtgtggaactcttcacggagaggccagggcctggcctaaaggca
gatgctgacagtcccctgtgtggcatcccagctccccagggcatctcttctctgacctca
gctgtgccccggccacgtgggaagctggcaggactcctccgcaccttcatgcgctctcgt
ccttctcgccagcggctgcgccaacggggaatcctgcggcagagggtgtttggttgtgat
cttggagagcacctcagcaactcaggccaagacgtgccccaagtgctgcgctgctgctct
gagtttattgaggcccatggtgtggtggatggaatctacaggctctctggcgtgtcctcc
aacatccagaggcttcggcatgagtttgatagtgagaggatccctgagctgtctggcccc
gccttcctacaagatatccacagtgtgtcctccctctgcaagctctacttccgggaactg
cccaaccccttgctcacctaccagctctatgggaagttcagtgaggctatgtcagtgcct
ggggaggaagaacgcctagtgcgagtgcatgacgtcatccagcagctgcctccaccacac
tacaggaccctggagtacctgctgaggcacctggcccgcatggcaagacacagcgctaac
accagcatgcatgcccgcaacctggccattgtctgggcacccaacctgctacggtctatg
gaactggagtcggtggggctgggtggggcagccgccttccgggaggtccgggtgcagtcg
gtggtggtggagttcctgcttacccacgtggaggttctgttcagcgatacgttcacctct
gctggcctggaccctgcaggtcgctgcctccttcccagacccaagtcccttgcggggagc
agtccctccactcgcctgctaacactggaagaagcccaggcacgaactcagggccgtctt
ggaacacctacagagcccacgactcctaagacgccagcctcaccagtggaaaggaggaaa
agagagagggcggagaaacaaaggaagccaggaggtagcagctggaagacattctttgct
ctggggcggggccccagcataccccggaagaagccgctgccatggctgggtggcagccga
gccccaccacagccttcaggcagcagacctgacactgtcacgctgagatctgccaaaagt
gaggagtctctgtcatcccaggccagcggggctggcctccagaggctgcaccggctgcga
cgaccccactccagcagcgatgcttttcccgtgggcccagcacctgctggctcttgcgag
agcttgtcctcttcttcttcctcttcttcctcttcctcctcctcctcctcctcagagtct
tcagcaggtggcctggggccactctctggctccccctcacaccgcacctcagcctggcta
gatgatggcgatgatctggatttcagtccaccccgctgtctggaaggacttcggggactt
gactttgatccccttacctttcgctgcagcagccccaccccaggggaccctgcacctcct
gccagcccagcacctccagcctcagcctctgccttcccacctcgggcaaccccacaggct
ctgtcaccccatggacccactaagcctgcttcacccactgccctggacatctcagagccc
ctggctgtatcagtaccacctgctgtcctggaactactgggagctggaggaacgcctgcc
tcagccaccccaacaccggctctcagccctcatctcatccccctgctgctgcgtggagct
gaggcccagctaagtgacacctgtcagcaggagatcagcagcaagctagcaccaacccgg
ggagctccaggccagcaaagtcctggcggcatggattcaccgttattgcccccacccttg
cctctgctgcgccctggtggggctccgccccctccccccaagaacccagctcgtctcatg
gccctggccttggctgagcgagctcagcaggtagcagagcaacagagccaacaagagcag
gggggcaccccacctgctccccactccccctttcgacgctctctgtccctagaggtgggt
ggggagcctgtggggacttcagggagtgggatacaccctccctccttagctcacccaggt
gcctgggctccaggtcccccaccttacctcccaaggcaacagagtgatgggagcctggta
agaagccagcggcccttggggacctcaaggagaagtcccagagggccttcccaggtcagt
gcccatctcagggcaagcggggcttacagggatgctccagagatggcagcccagtcacca
tgttctgtcccctcacagggttctaaccccagcttcttctcaaccccccgagagtgtttg
ccacctttccttggcgtccccaaacaaggcttgtactctctgggacccccatccttccca
cctagctctccagccccagtctggaggaactctctgggtgccccctcagcattggacagg
ggagagaatctgtactatgaaattggggtaggggaggggacctcctactcaggccccagc
cggtcctggagtccgtttcgctccatgcctcccgacaggcataatgcctcctatggtatg
cttggccagtcaccaccgctccacaggtcccctgatttcctgctcagctacccgcctccc
ccctcctgctttcccccagagcaccttacccactcagtttcacagcgccttgcccggcgc
cctacccgtcctgagcccctctatgtcaacctagccctagggcccaggggcccttcacct
gcctcttcttcctcttcctctcctcctgcccaccccaggagccggtcagatcctgggcct
cctgttccccgcctccctcagaaacagcgggctccttggggtccacatactccccatcgg
gtgcctggaccttggggttcccccgaaccttttctgctctataggccagctccaccatcc
tatgggaggggaggggaggtccgaggatccttgtacagaaatggaggacatagaggagag
ggggctggtccccctcctccttaccccacacccagctggtccttacattcagaaggacag
accagaagttactgcttaatta

Protein Sequence

>ARHGAP33
MLQAQKQSDPILPWGASWAGRGQTLRARSTDSLDGPGEGSVQPVPTTGGPGTKGKPGKRL
SAPRGPFPRLADCAHFHYENVDFGHIQLLLSPEREGPSLSGENELVFGVQVTCQGRSWPV
LRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGTRAAQMLVPLLLQYLETLSGLVDSN
LNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVVKRYTAQAPDELSFEVGDIVSVI
DMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADSPLCGIPAPQGISSLTS
AVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCS
EFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFREL
PNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSAN
TSMHARNLAIVWAPNLLRSMELESVGLGGAAAFREVRVQSVVVEFLLTHVEVLFSDTFTS
AGLDPAGRCLLPRPKSLAGSSPSTRLLTLEEAQARTQGRLGTPTEPTTPKTPASPVERRK
RERAEKQRKPGGSSWKTFFALGRGPSIPRKKPLPWLGGSRAPPQPSGSRPDTVTLRSAKS
EESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSSSSSSSSSSSES
SAGGLGPLSGSPSHRTSAWLDDGDDLDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPP
ASPAPPASASAFPPRATPQALSPHGPTKPASPTALDISEPLAVSVPPAVLELLGAGGTPA
SATPTPALSPHLIPLLLRGAEAQLSDTCQQEISSKLAPTRGAPGQQSPGGMDSPLLPPPL
PLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQEQGGTPPAPHSPFRRSLSLEVG
GEPVGTSGSGIHPPSLAHPGAWAPGPPPYLPRQQSDGSLVRSQRPLGTSRRSPRGPSQVS
AHLRASGAYRDAPEMAAQSPCSVPSQGSNPSFFSTPRECLPPFLGVPKQGLYSLGPPSFP
PSSPAPVWRNSLGAPSALDRGENLYYEIGVGEGTSYSGPSRSWSPFRSMPPDRHNASYGM
LGQSPPLHRSPDFLLSYPPPPSCFPPEHLTHSVSQRLARRPTRPEPLYVNLALGPRGPSP
ASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPHTPHRVPGPWGSPEPFLLYRPAPPS
YGRGGEVRGSLYRNGGHRGEGAGPPPPYPTPSWSLHSEGQTRSYCLI

  • Gold
  • Silver
  • Bronze
  • IntAct