Field Data
UniProt Accession: O15013
Gene Name: ARHGEF10
Gene Synonim: KIAA0294
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 10
Keywords: Alternative splicing;Coiled coil;Complete proteome;Disease mutation;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 9639
Ensembl Gene ID: ENSG00000274726
Ensembl Protein ID: ENSP00000488463
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005813centrosome
GO:0005829cytosol

Molecular Function


GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0019894kinesin binding
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process


GO ID Description
GO:0051298centrosome duplication
GO:0051496positive regulation of stress fiber assembly
GO:0090630activation of GTPase activity
GO:0022011myelination in peripheral nervous system
GO:0090307mitotic spindle assembly
GO:0035023regulation of Rho protein signal transduction

Reactome


Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG



Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic centrosomes nucleus

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF10
atggaccagcgagagcccctgcctcccgctcctgcagaaaatgaaatgaaatatgatacc
aataataatgaagaggaagagggagaacagttcgattttgacagtggagatgaaatccca
gaagcggacagacaggccccatccgcccctgagacaggaggtgctggagccagtgaagcc
cctgcacccacaggaggtgaggatggagctggagcagaaaccaccccagtggcagagcct
actaagctggtgctcccgatgaaagtcaacccatattctgtcatcgacatcacgccattc
caggaggaccagccgcccacccccgtgcccagcgctgaggaggagaatgtgggtctccat
gtgccctgcgggtacttggtgcctgtaccctgcggctatgcggtgccctccaacctgccc
ctcctgctgcccgcctactccagcccggtcatcatctgcgccacgtccctggacgaagaa
gaaacaccagaagtcacagaagatcgccagcccaattctctgagttccgaggagcctcca
accagtgaagatcaagtcggtcgagaggacagcgcacttgcccgctgggccgcagacccg
gccaacacagcctggatggagaatccagaggaagcaatttacgatgacgttccaagggaa
aactcagactctgaaccagatgaaatgatttatgatgatgttgagaatggggatgaaggt
ggaaacagctccttggaatacggatggagttcgagtgaatttgaaagttacgaagagcag
agtgactcggagtgcaagaatgggattcccaggtccttcctgcgcagcaaccacaaaaag
caactttctcatgacctaacccgtttaaaggagcactatgagaaaaagatgagagatttg
atggcaagcacggtgggcgtggtggagattcagcagctcaggcagaagcatgaactgaag
atgcagaagctcgtgaaggccgcgaaggacggcaccaaggacgggctggagaggaccagg
gcagccgtgaagaggggccgctccttcatcaggaccaagtctctcatcgcacaggatcac
agatcttctcttgaggaagaacagaatttgttcattgatgttgactgcaagcacccggaa
gccatcttgaccccgatgcccgagggtttatctcagcagcaggttgtaagaagatatata
ctgggttcagttgtcgacagtgaaaagaactacgtagatgctcttaagaggattttggag
caatatgagaagccgctgtctgagatggagccaaaggttctgagtgagaggaagctgaag
acggtgttctaccgagtcaaagagatcctgcagtgccactcgctatttcagatcgcgctg
gccagccgcgtttccgagtgggactccgtggaaatgataggcgatgtcttcgtggcttcg
ttttctaagtccatggtgctggatgcatacagtgaatatgtgaacaatttcagcacagcc
gtggcagtcctcaagaaaacatgtgccacaaagcccgcttttcttgaatttttaaagcag
gaacaggaggccagccccgatcgaaccacgctctacagcctgatgatgaagcccatccag
aggttcccacagttcatcctcctgctccaggacatgctgaagaacacctccaaaggccac
cccgacaggctgcctcttcagatggccctgacagagctcgaaacactagcagagaagtta
aatgaaagaaagagagatgctgatcaacgctgtgaagtgaagcaaatagccaaagccata
aacgaaagatacctgaacaagcttctcagcagtggaagccgatacctcattcgatcagat
gatatgatagaaacagtttacaacgacagaggagagattgttaaaaccaaagaacgccga
gtcttcatgttaaatgatgtgttaatgtgtgccaccgtcagctcacgcccctctcatgac
agccgtgtgatgagcagccagaggtacttgctgaagtggagcgttccactgggacatgtg
gacgccatcgagtatggcagcagcgcaggcacgggcgagcacagcaggcaccttgccgtt
cacccgccggagagcctggccgtggttgctaacgcgaaaccaaacaaagtttacatgggg
ccaggacaactgtatcaagatttacaaaacttgttgcatgacttaaatgtaattggccaa
atcactcagctgataggaaaccttaaaggaaactatcagaacttaaaccagtcagtagcc
catgactggacatcaggtttacaaaggcttattttgaagaaagaagatgaaatcagagct
gcggactgctgcagaattcagttacagcttcccgggaagcaggacaaatctgggcgaccg
acgttctttacagctgtgttcaatacgttcacccctgccatcaaggagtcctgggtcaac
agcttacagatggccaagctcgccctagaagaggagaaccacatgggctggttctgtgtg
gaagacgatgggaatcacattaaaaaggagaagcatcctctcctcgtcggacacatgccc
gtgatggtggccaagcagcaggagttcaagattgaatgtgctgcttataaccctgaacct
tacctaaataatgaaagccagccagattcattttccacggcacatggtttcctgtggatc
ggaagttgcacccatcaaatgggtcagattgccatcgtctcgtttcaaaattccactccc
aaagtcattgagtgcttcaacgtggaatctcgcatcctgtgcatgctgtacgttcccgtc
gaggagaagcgcagagagcctggggcacccccggaccccgagaccccggccgtgagagct
tctgatgtccccacgatctgtgtagggacggaggagggaagcatttccatttataaaagc
agtcaaggctccaagaaagtgagacttcagcactttttcactcctgagaagtccacagtc
atgagcctggcttgcacgtctcagagcctgtacgctggcctggtcaacggggcagtcgcc
agctacgccagagccccagatggatcctgggattcagaacctcaaaaagtgatcaagtta
ggcgtcctaccagttagaagtctactcatgatggaagacacgttgtgggcggcttccgga
ggtcaagtcttcatcatcagtgtggagactcatgctgtagagggtcagctggaggcccac
caggaggaaggcatggtgatctcccacatggccgtgtccggcgtcgggatctggattgcc
ttcacctcagggtccacgctccgcctttttcacacggaaactctcaagcacctgcaggac
atcaacatcgccacccctgttcacaacatgctgccagggcaccagcggctgtcggtgacg
agcctgctcgtctgccacggattgctgatggtcggcaccagcctgggagtcctcgtggcc
ctgccggtcccacgtctgcaagggattcccaaagtgaccggaagaggcatggtctcctac
catgcacacaacagtcctgtcaaattcatcgtcctggccacggctctgcacgagaaagac
aaggacaaatccagggacagcctggctcctggccccgagcctcaggacgaagaccagaag
gacgcacttccgagtggaggagctggttcatctctgagccagggtgaccctgacgcagcc
atctggttgggagattcgctgggatcgatgactcagaaaagcgacctgtcctcctcatct
gggtccctgagcttgtctcacggctccagctctctagagcacagatcagaggacagcacc
atctatgatctcctgaaggatcctgtctcgctgagaagcaaagcacgccgggccaagaaa
gccaaggccagctcggcgctggtggtctgtggagggcagggccaccgccgggtgcacagg
aaggcccggcagccccaccaggaagagctggcgccgaccgtcatggtctggcagatccct
ctgctgaatataggaagctt

Protein Sequence

>ARHGEF10
MDQREPLPPAPAENEMKYDTNNNEEEEGEQFDFDSGDEIPEADRQAPSAPETGGAGASEA
PAPTGGEDGAGAETTPVAEPTKLVLPMKVNPYSVIDITPFQEDQPPTPVPSAEEENVGLH
VPCGYLVPVPCGYAVPSNLPLLLPAYSSPVIICATSLDEEETPEVTEDRQPNSLSSEEPP
TSEDQVGREDSALARWAADPANTAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGDEG
GNSSLEYGWSSSEFESYEEQSDSECKNGIPRSFLRSNHKKQLSHDLTRLKEHYEKKMRDL
MASTVGVVEIQQLRQKHELKMQKLVKAAKDGTKDGLERTRAAVKRGRSFIRTKSLIAQDH
RSSLEEEQNLFIDVDCKHPEAILTPMPEGLSQQQVVRRYILGSVVDSEKNYVDALKRILE
QYEKPLSEMEPKVLSERKLKTVFYRVKEILQCHSLFQIALASRVSEWDSVEMIGDVFVAS
FSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDRTTLYSLMMKPIQ
RFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLNERKRDADQRCEVKQIAKAI
NERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMCATVSSRPSHD
SRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPPESLAVVANAKPNKVYMG
PGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQRLILKKEDEIRA
ADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMAKLALEEENHMGWFCV
EDDGNHIKKEKHPLLVGHMPVMVAKQQEFKIECAAYNPEPYLNNESQPDSFSTAHGFLWI
GSCTHQMGQIAIVSFQNSTPKVIECFNVESRILCMLYVPVEEKRREPGAPPDPETPAVRA
SDVPTICVGTEEGSISIYKSSQGSKKVRLQHFFTPEKSTVMSLACTSQSLYAGLVNGAVA
SYARAPDGSWDSEPQKVIKLGVLPVRSLLMMEDTLWAASGGQVFIISVETHAVEGQLEAH
QEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPGHQRLSVT
SLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSYHAHNSPVKFIVLATALHEKD
KDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSDLSSSS
GSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR
KARQPHQEELAPTVMVWQIPLLNIGS

  • Gold
  • Silver
  • Bronze
  • IntAct