Field Data
UniProt Accession: O43182
Gene Name: ARHGAP6
Gene Synonim: RHOGAP6
GAP/GEF: GAP
Description: Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)
Keywords: Alternative splicing;Complete proteome;Cytoplasm;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;SH3-binding
Entrez ID: 395
Ensembl Gene ID: ENSG00000047648
Ensembl Protein ID: ENSP00000435767
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005884actin filament
GO:0015629actin cytoskeleton

Molecular Function

GO ID Description
GO:0005070SH3/SH2 adaptor activity
GO:0043274phospholipase binding
GO:0005096GTPase activator activity
GO:0016004phospholipase activator activity
GO:0017124SH3 domain binding

Biological Process

GO ID Description
GO:0007015actin filament organization
GO:0043547positive regulation of GTPase activity
GO:0051056regulation of small GTPase mediated signal transduction
GO:0051497negative regulation of stress fiber assembly
GO:0009967positive regulation of signal transduction
GO:0007202activation of phospholipase C activity
GO:0010518positive regulation of phospholipase activity
GO:0007165signal transduction
GO:0048041focal adhesion assembly
GO:0030041actin filament polymerization
GO:0007266Rho protein signal transduction
GO:0043087regulation of GTPase activity
GO:0051895negative regulation of focal adhesion assembly

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: actin

Confocal Images

Card image cap

Cytochalasin D Screen Negative

Card image cap
organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ARHGAP6
atgtccgcgcagagcctgctccacagcgtcttctcctgttcctcgcccgcttcaagtagc
gcggcctcggccaagggcttctccaagaggaagctgcgccagacccgcagcctggacccg
gccctgatcggcggctgcgggagcgacgaggcgggcgcggagggcagtgcgcggggagcc
acggcgggccgcctctactccccatcactcccagccgagagtctcggccctcgcttggcg
tcctcttcccggggtccgccccccagggccaccaggctaccgcctcctggacctctttgc
tcgtccttctccacacccagcaccccgcaggagaagtcaccatccggcagctttcacttt
gactatgaggttcccctgggtcgcggcggcctcaagaagagcatggcctgggacctgcct
tctgtcctggccgggccagccagtagccgaagcgcttccagcatcctctgttcatccggg
ggaggccccaatggcatcttcgcttctcctaggaggtggctccagcagaggaagttccag
tccccacccgacagtcgcgggcacccctacgtcgtgtggaaatccgagggtgatttcacc
tggaacagcatgtcaggccgcagtgtacggctgaggtcagtccccatccagagtctctca
gagctggagagggcccggctgcaggaagtggctttttatcagttgcaacaggactgtgac
ctgagctgtcagatcaccattcccaaagatggacaaaagagaaagaaatctttaagaaag
aaactggattcactaggaaaggagaaaaacaaagacaaagaattcatcccacaggcattt
ggaatgcccttatcccaagtcattgcgaatgacagggcctataaactcaagcaggacttg
cagagggacgagcagaaagatgcatctgactttgtggcttccctcctcccatttggaaat
aaaagacaaaacaaagaactctcaagcagtaactcatctctcagctcaacctcagaaaca
ccgaatgagtcaacgtccccaaacaccccggaaccggctcctcgggctaggaggaggggt
gccatgtcagtggattctatcaccgatcttgatgacaatcagtctcgactactagaagct
ttacaactttccttgcctgctgaggctcaaagtaaaaaggaaaaagccagagataagaaa
ctcagtctgaatcctatttacagacaggtccctaggctggtggacagctgctgtcagcac
ctagaaaaacatggcctccagacagtggggatattccgagttggaagctcaaaaaagaga
gtgagacaattacgtgaggaatttgaccgtgggattgatgtctctctggaggaggagcac
agtgttcatgatgtggcagccttgctgaaagagttcctgagggacatgccagaccccctt
ctcaccagggagctgtacacagctttcatcaacactctcttgttggagccggaggaacag
ctgggcaccttgcagctcctcatataccttctacctccctgcaactgcgacaccctccac
cgcctgctacagttcctctccatcgtggccaggcatgccgatgacaacatcagcaaagat
gggcaagaggtcactgggaataaaatgacatctctaaacttagccaccatatttggaccc
aacctgctgcacaagcagaagtcatcagacaaagaattctcagttcagagttcagcccgg
gctgaggagagcacggccatcatcgctgttgtgcaaaagatgattgaaaattatgaagcc
ctgttcatggttcccccagatctccagaacgaagtgctgatcagcctgttagagaccgat
cctgatgtcgtggactatttactcagaagaaaggcttcccaatcatcaagccctgacatg
ctgcagtcggaagtttccttttccgtgggagggaggcattcatctacagactccaacaag
gcctccagcggagacatctccccttatgacaacaactccccagtgctgtctgagcgctcc
ctgctggctatgcaagaggacgcggccccggggggctcggagaagctttacagagtgcca
gggcagtttatgctggtgggccacttgtcgtcgtcaaagtcaagggaaagttctcctgga
ccaaggcttgggaaagatctgtcagaggagcctttcgatatctggggaacttggcattca
acattaaaaagcggatccaaagacccaggaatgacaggttcctctggagacatttttgaa
agcagctccctaagagcggggccctgctccctttctcaagggaacctgtccccaaattgg
cctcggtggcaggggagccccgcagagctggagagcgacacgcagggggctcggaggact
caggccgcagcccccgcgacggagggcagggcccaccctgcggtgtcgcgcgcctgcagc
acgccccacgtccaggtggcagggaaagccgagcggcccacggccaggtcggagcagtac
ttgaccctgagcggcgcccacgacctcagcgagagtgagctggatgtggccgggctgcag
agccgggccacacctcagtgccaaagaccccatgggagtgggagggatgacaagcggccc
ccgcctccatacccgggcccagggaagcccgcggcagcggcagcctggatccaggggccc
ccggaaggcgtggagacacccacggaccagggaggccaagcagccgagcgagagcagcag
gtcacgcagaaaaaactgagcagcgccaactccctgccagcgggcgagcaggacagtccg
cgcctgggggacgctggctggctcgactggcagagagagcgctggcagatctgggagctc
ctgtcgaccgacaaccccgatgccctgcccgagacgctggtcttaatta

Protein Sequence

>ARHGAP6
MSAQSLLHSVFSCSSPASSSAASAKGFSKRKLRQTRSLDPALIGGCGSDEAGAEGSARGA
TAGRLYSPSLPAESLGPRLASSSRGPPPRATRLPPPGPLCSSFSTPSTPQEKSPSGSFHF
DYEVPLGRGGLKKSMAWDLPSVLAGPASSRSASSILCSSGGGPNGIFASPRRWLQQRKFQ
SPPDSRGHPYVVWKSEGDFTWNSMSGRSVRLRSVPIQSLSELERARLQEVAFYQLQQDCD
LSCQITIPKDGQKRKKSLRKKLDSLGKEKNKDKEFIPQAFGMPLSQVIANDRAYKLKQDL
QRDEQKDASDFVASLLPFGNKRQNKELSSSNSSLSSTSETPNESTSPNTPEPAPRARRRG
AMSVDSITDLDDNQSRLLEALQLSLPAEAQSKKEKARDKKLSLNPIYRQVPRLVDSCCQH
LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPL
LTRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKD
GQEVTGNKMTSLNLATIFGPNLLHKQKSSDKEFSVQSSARAEESTAIIAVVQKMIENYEA
LFMVPPDLQNEVLISLLETDPDVVDYLLRRKASQSSSPDMLQSEVSFSVGGRHSSTDSNK
ASSGDISPYDNNSPVLSERSLLAMQEDAAPGGSEKLYRVPGQFMLVGHLSSSKSRESSPG
PRLGKDLSEEPFDIWGTWHSTLKSGSKDPGMTGSSGDIFESSSLRAGPCSLSQGNLSPNW
PRWQGSPAELESDTQGARRTQAAAPATEGRAHPAVSRACSTPHVQVAGKAERPTARSEQY
LTLSGAHDLSESELDVAGLQSRATPQCQRPHGSGRDDKRPPPPYPGPGKPAAAAAWIQGP
PEGVETPTDQGGQAAEREQQVTQKKLSSANSLPAGEQDSPRLGDAGWLDWQRERWQIWEL
LSTDNPDALPETLVLI

  • Gold
  • Silver
  • Bronze
  • IntAct