Field Data
UniProt Accession: O43295
Gene Name: SRGAP3
Gene Synonim: ARHGAP14, KIAA0411, KIAA1156, MEGAP, SRGAP2
GAP/GEF: GAP
Description: SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)
Keywords: Alternative splicing;Chromosomal rearrangement;Coiled coil;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 9901
Ensembl Gene ID: ENSG00000196220
Ensembl Protein ID: ENSP00000373347
Our Specificity Rac1
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0048365Rac GTPase binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0030336negative regulation of cell migration
GO:0007165signal transduction
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle
R-HSA-428543Inactivation of CDC42 and RAC1

KEGG

Kegg ID Description
hsa04360Axon guidance
Field Data
Localization in this study: focal_adhesions
Localization in the literature: focal adhesions nucleus

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>SRGAP3
atgtcatctcaaactaagttcaagaaagacaaagagatcattgctgaatatgaagcccaa
ataaaagagatccgcacgcagctggtggagcagttcaaatgtctggagcagcaatcagag
tcgcgactgcagctgcttcaagacctccaggagtttttccgccggaaagctgagattgag
ctcgagtactcccgcagcctggagaagctggctgagcgcttctcctccaaaatccgcagc
tcccgggagcaccagttcaagaaggaccagtacctcctctcgcctgtgaactgttggtat
ctggttctgcatcagacccggcgggagagccgagaccatgccaccctcaatgacatcttc
atgaacaatgtcatcgtccgcctctcccagatcagtgaggatgtcatcagactcttcaaa
aagagcaaggagattggcctgcagatgcacgaggagctcctgaaggtgaccaatgagctc
tacacagtcatgaaaacctaccacatgtaccatgcagagagcatcagtgcggaaagcaag
ctgaaggaggctgagaagcaggaggagaagcagttcaataagtcaggagacctcagcatg
aacctgctccggcacgaggaccggccccagcgccgcagctctgtgaagaagattgagaag
atgaaggagaagaggcaggccaagtactctgagaacaagctgaaatgcacaaaggcccgg
aatgactacttgctcaatctggcagccaccaacgcagctataagcaaatactacatccat
gatgtctctgatctgatcgattgctgtgatttgggcttccatgccagcctggcccgcacc
ttccggacctatctctcagctgaatacaacctggagacctctcgccacgaagggctggat
gtcattgagaatgcagtggacaacctggattcccgaagtgacaagcacacagtcatggac
atgtgcaatcaagtcttctgccctccactcaagttcgagttccagccccacatgggggat
gaggtctgccaggtcagcgctcagcagcccgtccagacagaactgctcatgcgttatcac
cagctgcagtccagactggccaccctcaagatagagaatgaggaggttaggaaaaccctg
gatgccaccatgcagacattacaggacatgctgactgtggaggactttgatgtctccgat
gccttccaacacagtcgatcgacagagtccgtcaagtcggctgcctctgagacctacatg
agcaagatcaacattgccaagaggagagccaaccagcaggaaacagaaatgttttatttt
acaaaatttaaagagtatgtgaatggcagtaacctcatcaccaagctgcaggccaagcac
gatttactcaagcagaccctgggcgaaggggaaagagcagaatgcggcaccaccagagga
agaagaaatgctcgaaccaggaaccaggattcaggacaagctataccgcttgtagtcgag
agctgcatccgttacatcaatttatatggactccagcagcaggggatcttcagagtgcca
ggatctcaggtggaagtcaatgacatcaaaaattcctttgagagaggtgaagaccccctt
gtggacgatcaaaatgaacgagatatcaattcagtcgctggtgttttaaaactgtatttc
cgaggactggaaaacccactctttcctaaggaaaggtttcaagatttgatatctactatt
aaactggagaacccagccgagagggtgcaccagatccaacaaatcctcgtcacccttccc
cgcgtggtcattgtggtcatgagatacctcttcgctttcctcaaccacctctcccagtat
agcgacgagaacatgatggatccctacaacctggccatctgcttcgggcctaccctcatg
cacatccctgatgggcaggaccctgtgtcctgccaggcacacatcaatgaagtcatcaaa
accatcatcatccatcatgaagccatcttccccagcccccgggagctagagggacctgtg
tatgaaaaatgcatggctggaggggaagaatattgtgacagcccacacagcgagccaggg
gccatcgatgaagttgaccatgacaatggcactgagcctcataccagcgatgaagaagtg
gagcagatcgaggctattgccaagtttgactacatggggcggtccccgcgtgagctatcc
ttcaagaagggggcctcgctgctcctgtaccaccgcgcctcggaggactggtgggagggc
cggcacaacggcgtggatggactcatcccccatcagtacatagttgtacaggacatggat
gatgccttctccgacagcctgagccagaaggctgacagcgaggccagcagtgggccattg
ctggatgacaaggcctcttccaaaaacgacctccagtcccccacggagcacatctcggat
tacggctttgggggggtgatgggccgagtgcggttacgatctgatggagcagccatcccc
agacgccgaagcgggggcgacacacacagcccgccccggggcctgggccccagcatagac
acaccaccccgggctgctgcctgccccagcagcccccacaaaatccccctcacccggggg
aggatcgagagccctgagaagcggaggatggcgacgttcgggagcgctggcagcatcaac
taccctgacaagaaggcgctctccgaagggcactcgatgaggtcgacctgcggttccacc
aggcacagcagcctaggggaccacaagtccctggaggccgaggccctggcagaagacatc
gagaagaccatgagcacggctctgcacgagttgcgggaactcgagaggcagaacacggtc
aagcaggcgccagatgtggtgctggacaccctggagcccctgaagaacccgccaggcccc
gtcagctcggagcccgccagtccccttcacaccatcgtcatccgcgaccccgatgccgcc
atgcgccgcagcagcagctcctccaccgagatgatgaccaccttcaagccagccctgtcc
gcccgcctggctggcgcccagctccgcccgccccccatgcggcccgtgcggccggtggtc
cagcaccggtccagcagcagcagcagctcgggcgtgggcagcccggccgtgacgcccacc
gagaagatgttccccaacagctcagcggacaagtcgggcaccatggttttaatta

Protein Sequence

>SRGAP3
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRG
RRNARTRNQDSGQAIPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPL
VDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLP
RVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIK
TIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPHSEPGAIDEVDHDNGTEPHTSDEEV
EQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASEDWWEGRHNGVDGLIPHQYIVVQDMD
DAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTEHISDYGFGGVMGRVRLRSDGAAIP
RRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIPLTRGRIESPEKRRMATFGSAGSIN
YPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEALAEDIEKTMSTALHELRELERQNTV
KQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRDPDAAMRRSSSSSTEMMTTFKPALS
ARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPAVTPTEKMFPNSSADKSGTMVLI

  • Gold
  • Silver
  • Bronze
  • IntAct