Field Data
UniProt Accession: O43307
Gene Name: ARHGEF9
Gene Synonim: ARHDH9, KIAA0424
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 9 (Collybistin) (PEM-2 homolog) (Rac/Cdc42 guanine nucleotide exchange factor 9)
Keywords: 3D-structure;Alternative splicing;Complete proteome;Cytoplasm;Disease mutation;Epilepsy;Guanine-nucleotide releasing factor;Phosphoprotein;Reference proteome;SH3 domain
Entrez ID: 23229
Ensembl Gene ID: ENSG00000131089
Ensembl Protein ID: ENSP00000485626
Our Specificity Cdc42
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0043065positive regulation of apoptotic process
GO:0034220ion transmembrane transport
GO:0043547positive regulation of GTPase activity
GO:0051056regulation of small GTPase mediated signal transduction
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-977441GABA A receptor activation
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF9
atgacgttgctgatcactggagattccatcgttagtgctgaggcagtatgggatcacgtc
accatggccaaccgggagttggcatttaaagctggcgacgtcatcaaagtcttggatgct
tccaacaaggattggtggtggggccagatcgacgatgaggagggatggtttcctgccagc
tttgtgaggctctgggtgaaccaggaggatgaggtggaggaggggcccagcgatgtgcag
aacggacacctggaccccaattcagactgcctctgtctggggcggccactacagaaccgg
gaccagatgcgggccaatgtcatcaatgagataatgagcactgagcgtcactacatcaag
cacctcaaggatatttgtgagggctatctgaagcagtgccggaagagaagggacatgttc
agtgacgagcaactgaaggtaatctttgggaacattgaagatatctacagatttcagatg
ggctttgtgagagacctggagaaacagtataacaatgatgacccccacctcagcgagata
ggaccctgcttcctagagcaccaagatggattctggatatactctgagtattgtaacaac
cacctggatgcttgcatggagctctccaaactgatgaaggacagccgctaccagcacttc
tttgaggcctgtcgcctcttgcagcagatgattgacattgctatcgatggtttccttttg
actccagtgcagaagatctgcaagtatcccttacagttggctgagctcctaaagtatact
gcccaagaccacagtgactacaggtatgtggcagctgctttggctgtcatgagaaatgtg
actcagcagatcaacgaacgcaagcgacgtttagagaatattgacaagattgctcagtgg
caggcttctgtcctagactgggagggcgaggacatcctagacaggagctcggagctgatc
tacactggggagatggcctggatctaccagccctacggccgcaaccagcagcgggtcttc
ttcctgtttgaccaccagatggtcctctgcaagaaggacctaatccggagagacatcctg
tactacaaaggccgcattgacatggataaatatgaggtagttgacattgaggatggcaga
gatgatgacttcaatgtcagcatgaagaatgcctttaagcttcacaacaaggagactgag
gagatacatctgttctttgccaagaagctggaggaaaaaatacgctggctcagggctttc
agagaagagaggaaaatggtacaggaagatgaaaaaattggctttgaaatttctgaaaac
cagaagaggcaggctgcaatgactgtgagaaaagtccctaagcaaaaaggtgtcaactct
gcccgctcagttcctccttcctacccaccaccgcaggacccgttaaaccacggccagtac
ctggtccccgacggcatcgctcagtcgcaggtctttgagttcaccgaacccaagcgcagc
cagtcaccattctggcaaaacttcagcaggttaacccccttcaaaaaattaatta

Protein Sequence

>ARHGEF9
MTLLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPAS
FVRLWVNQEDEVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIK
HLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEI
GPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMIDIAIDGFLL
TPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQW
QASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLCKKDLIRRDIL
YYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKETEEIHLFFAKKLEEKIRWLRAF
REERKMVQEDEKIGFEISENQKRQAAMTVRKVPKQKGVNSARSVPPSYPPPQDPLNHGQY
LVPDGIAQSQVFEFTEPKRSQSPFWQNFSRLTPFKKLI

  • Gold
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  • Bronze
  • IntAct