Field Data
UniProt Accession: O75962
Gene Name: TRIO
Gene Synonim:
GAP/GEF: GEF
Description: Triple functional domain protein (EC 2.7.11.1) (PTPRF-interacting protein)
Keywords: 3D-structure;ATP-binding;Alternative splicing;Complete proteome;Cytoplasm;Disease mutation;Disulfide bond;Guanine-nucleotide releasing factor;Immunoglobulin domain;Kinase;Mental retardation;Nucleotide-binding;Phosphoprotein;Polymorphism;Reference proteome;Repeat;SH3 domain;Serine/threonine-protein kinase;Transferase
Entrez ID: 7204
Ensembl Gene ID: ENSG00000038382
Ensembl Protein ID: ENSP00000339299
Our Specificity Rac1
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function


GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0016301kinase activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0019899enzyme binding
GO:0000166nucleotide binding
GO:0004674protein serine/threonine kinase activity
GO:0016740transferase activity
GO:0005515protein binding
GO:0004672protein kinase activity
GO:0005524ATP binding

Biological Process


GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0006468protein phosphorylation
GO:0043547positive regulation of GTPase activity
GO:0016310phosphorylation
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction
GO:0045599negative regulation of fat cell differentiation
GO:0007185transmembrane receptor protein tyrosine phosphatase signaling pathway

Reactome


Reactome ID Description
R-HSA-418885DCC mediated attractive signaling
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-416476G alpha (q) signalling events
R-HSA-193648NRAGE signals death through JNK

KEGG



Field Data
Localization in this study: basal_membrane_filaments, focal_adhesions
Localization in the literature: plasma membrane (junctions) plasma membrane

Confocal Images


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Cytochalasin D Screen Negative


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TIRF


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>TRIO
atgaaagctatggatgttttaccaattttgaaggaaaaagttgcatacctttcaggtggg
agagataaacgtggaggtcccattttaacgtttccggcccgcagcaatcatgacagaata
cgacaggaggatctcaggagactcatttcctatctagcctgtattcccagcgaggaggtc
tgcaagcgtggcttcacggtgatcgtggacatgcgtgggtccaagtgggactccatcaag
ccccttctgaagatcctgcaggagtccttcccctgctgcatccatgtggccctgatcatc
aagccagacaacttctggcagaaacagaggactaattttggcagttctaaatttgaattt
gagacaaatatggtctctttagaaggccttaccaaagtagttgatccttctcagctaact
cctgagtttgatggctgcctggaatacaaccacgaagaatggattgaaatcagagttgct
tttgaagactacattagcaatgccacccacatgctgtctcggctggaggaacttcaggac
atcctagctaagaaggagctgcctcaggatttagagggggctcggaatatgatcgaggaa
cattctcagctgaagaagaaggtgattaaggcccccatcgaggacctggatttggaggga
cagaagctgcttcagaggatacagagcagtgaaagctttcccaaaaagaactcaggctca
ggcaatgcggacctgcagaacctcttgcccaaggtgtccaccatgctggaccggctgcac
tcgacacggcagcatctgcaccagatgtggcatgtgaggaagctgaagctggaccagtgc
ttccagctgaggctgtttgaacaggatgctgagaagatgtttgactggatcacacacaac
aaaggcctgtttctaaacagctacacagagattgggaccagccaccctcatgccatggag
cttcagacgcagcacaatcactttgccatgaactgtatgaacgtgtatgtaaatataaac
cgcatcatgtcggtggccaatcgtctggtggagtctggccactatgcctcgcagcagatc
aggcagatcgcgagtcagctggagcaggagtggaaggcgtttgcggcagccctggatgag
cggagcaccttgctggacatgtcctccattttccaccagaaggccgaaaagtatatgagc
aacgtggattcatggtgtaaagcttgcggtgaggtagaccttccctcagagctgcaggac
ctagaagatgccattcatcaccaccagggaatatatgaacatatcactcttgcttattct
gaggtcagccaagatgggaagtcgctccttgacaagctccagcggcccttgactcccggc
agctccgattccctgacagcctctgccaactactccaaggccgtgcaccatgtcctggat
gtcatccacgaggtgctgcaccaccagcggcagctggagaacatctggcaacaccgcaag
gtccggctgcatcagaggctgcagctgtgtgttttccagcaggacgttcagcaggtgcta
gactggatcgagaaccacggagaagcatttctgagcaaacatacaggtgtggggaaatct
cttcatcgggccagagcattgcagaaacgtcatgaagattttgaagaagtggcacagaac
acatacaccaatgcggataaattactggaagcagcagaacagctggctcagactggggaa
tgtgaccccgaagagatttatcaggctgcccatcagctggaagaccggattcaagatttc
gttcggcgtgttgagcagcgaaagatcctactggacatgtcagtgtcctttcacacccat
gtgaaagagctgtggacgtggctggaggagctgcagaaggagctgctggacgacgtgtat
gccgagtcggtggaggccgtgcaggacctcatcaagcgctttggccagcagcagcagacc
accctgcaggtgactgtcaacgtgatcaaggaaggggaggacctcatccagcagctcagg
gactctgccatctccagtaacaagaccccccacaacagctccatcaaccacattgagacg
gtgctgcagcagctggacgaggcgcagtcgcagatggaggagctcttccaggagcgcaag
atcaagctggagctcttcctgcagctgcgcatcttcgagagggacgccatcgacattatc
tcagacctcgagtcttggaatgatgagctttctcagcaaatgaatgacttcgacacagaa
gatctcacgattgcagagcagcgcctccagcaccatgcagacaaagccttgaccatgaac
aacttgacttttgacgtcatccaccaagggcaagatcttctgcagtatgtcaatgaggtc
caggcctctggtgtggagctgctgtgtgatagagatgtagacatggcaactcgggtccag
gacctgctggagtttcttcatgaaaaacagcaggaattggatttagccgcagagcagcat
cggaaacacctggagcagtgcgtgcagctgcgccacctgcaggcagaagtgaaacaggtg
ctgggttggatccgcaacggagagtccatgttaaatgccggacttatcacagccagctcg
ttacaagaggcagagcagctccagcgagagcacgagcagttccagcatgccattgagaaa
acacatcagagcgcgctgcaggtgcagcagaaggcagaagccatgctacaggccaaccac
tacgacatggacatgatccgggactgcgccgagaaggtggcgtctcactggcaacagctc
atgctcaagatggaagatcgcctcaagctcgtcaacgcctctgtcgctttctacaaaacc
tcagagcaggtctgcagcgtcctcgagagcctggaacaggagtacaagagagaagaagac
tggtgtggcggggcggataagctgggcccaaactctgagacggaccacgtgacgcccatg
atcagcaagcacctggagcagaaggaggcattcctgaaggcttgcacccttgctcggagg
aatgcagacgtcttcctgaaatacctgcacaggaacagcgtgaacatgccaggaatggtg
acgcacatcaaagctcctgaacagcaagtgaaaaatatcttgaatgaactcttccaacgg
gagaacagggtattgcattactggaccatgaggaagagacggctggaccagtgtcagcag
tacgtggtctttgagaggagtgccaagcaggctttggaatggatccatgacaatggcgag
ttctacctttccacacacacctccacgggctccagtatacagcacacccaggagctcctg
aaagagcacgaggagttccagataactgcaaagcaaaccaaagagagagtgaagctattg
atacagctggctgatggcttttgtgaaaaagggcatgcccatgcggcagagataaaaaaa
tgtgttactgctgtggataagaggtacagagatttctctctgcggatggagaagtacagg
acctctttggaaaaagccctggggatttcttcagattccaacaaatcgagtaaaagtctc
cagctagatatcattccagccagtatccctggctcagaggtgaaacttcgagatgctgct
catgaacttaatgaagagaagcggaaatctgcccgcaggaaagagttcataatggctgag
ctcattcaaactgaaaaggcttatgtaagagacctccgggaatgtatggatacgtacctg
tgggaaatgaccagtggcgtggaagagattccacctggcattgtaaacaaagaactcatc
atcttcggaaacatgcaagaaatctacgaatttcataataacatattcctaaaggagctg
gaaaaatatgaacagttgccagaggatgttggacattgttttgttacttgggcagacaag
tttcagatgtatgtcacatattgcaaaaataagcctgattctactcagctgatattggaa
catgcagggtcctattttgacgagatacagcagcgacatggattagccaattccatttct
tcctaccttattaaaccagttcagcgaataacgaagtatcagctccttttaaaagagctg
ctgacgtgctgtgaggaaggaaagggagagattaaagatggcctggaggtgatgctcagc
gtgccgaagcgagccaatgatgccatgcacctcagcatgctggaagggtttgatgaaaac
attgagtctcagggagaactcatcctacaggaatccttccaagtgtgggacccaaaaacc
ttaattcgaaagggtcgagaacggcatctcttcctttttgaaatgtccttagtatttagt
aaagaagtgaaagattccagtgggagaagcaagtacctttataaaagcaaattgtttacc
tcagagttgggtgtcacagaacatgttgaaggagacccttgcaaatttgcactgtgggtg
gggagaacaccaacttcagataataaaattgtccttaaggcttccagcatagagaacaag
caggactggataaagcatatccgcgaagtcatccaggagcggacgatccacctgaaggga
gccctgaaggagcccattcacatccctaagaccgctcccgccacaagacagaagggaagg
agggatggagaggatctggacagccaaggagacggcagcagccagcctgatacgatttcc
atcgcctcacggacgtctcagaacacgctggacagcgataagctctctggtggctgtgag
ctgacagtggtgatccatgacttcaccgcttgcaacagcaacgagctgaccatccgacgg
ggccagaccgtggaagttctggagcggccgcatgacaagcctgactggtgtctggtgcgg
acaactgaccgctccccagcggcagaaggcctggtcccctgtggttcactgtgcatcgcc
cactccagaagtagcatggaaatggagggcatcttcaaccacaaagactcgctctccgtc
tccagcaatgacgccagtccacccgcatccgtggcttccctccagccccacatgatcggg
gcccagagctcgccgggccccaagcggccgggcaacaccctgcgcaagtggctcaccagc
cccgtgcggcggctcagcagcggcaaggccgacgggcacgtgaagaagctggcgcacaag
cacaagaagagccgcgaggtccgcaagagcgccgacgccggctcgcagaaggactccgac
gacagtgcggccaccccgcaggacgagacggtcgaggagagaggccggaacgagggcctg
agcagcggtactctctccaaatcctcctcctcggggatgcagagctgtggagaagaggaa
ggcgaggagggggccgacgccgtgcccctgccgccacccatggccatccagcagcacagc
ctcctccagccagactcacaggatgacaaggcctcttctcggttattagtccgccccacc
agctccgaaacaccgagtgcagccgagctcgtcagtgcaattgaggaactcgtgaaaagc
aagatggcactggaggatcgccccagctcactccttgttgaccagggagatagtagcagc
ccttccttcaacccttcggataattcccttctctcttcctcctcgcccattgatgagatg
gaagaaaggaaatccagctctttaaagagaagacactacgttttgcaagaactagtggag
acagagcgtgactatgtgcgggaccttggctatgtggttgagggctacatggcacttatg
aaagaagatggtgttcctgatgacatgaaaggaaaagacaaaattgtgttcggcaacatc
catcagatttacgactggcacagagacttttttttaggagagttagagaagtgccttgaa
gatccagaaaaactaggatccctttttgttaaacacgagagaaggttgcacatgtacata
gcttattgtcaaaataaaccaaagtctgagcacattgtctcagaatacattgataccttt
tttgaggacttaaagcagcgtcttggccacaggttacagctcacagatctgttgatcaaa
ccagtgcagagaatcatgaagtatcagctgttactgaaggacttcctcaagtattccaaa
aaggccagcctggatacatcagaattagagagagctgtggaagtcatgtgcatagtaccc
aggcggtgcaacgacatgatgaacgtggggcggctgcaaggattcgacgggaaaatcgtt
gcccagggtaaactgctcttgcaggacacattcttggtcacagaccaagatgcaggactt
ctgcctcgctgcagagagaggcgcatcttcctctttgagcagatcgtcatattcagcgaa
ccacttgataaaaagaagggcttctccatgccgggattcctgtttaagaacagtatcaag
gtgagttgcctttgcctggaggaaaatgtggaaaatgatccctgtaaatttgctctgaca
tcgaggacgggtgacgtggtagagaccttcattttgcattcatctagtccaagtgtccgg
caaacttggatccatgaaatcaaccaaattttagaaaaccagcgcaattttttaaatgcc
ttgacatcgccaatcgagtaccagaggaaccacagcgggggcggcggcggcggcggcagc
gggggcagcggcgggggtgggggcagcggcggcggcggggcccccagtggcggcagcggc
cacagtggcggccccagcagctgcggcggcgcccccagcacgagcaggagccggccctcc
cggatcccccagcctgtccgacaccacccccccgtgctggtctcctctgcagcctcgagc
caggcagaggcagacaagatgtcaggtacgtccacccccgggccctccctgcctccccct
ggcgcggcccccgaggccggccccagcgcgcccagcaggcggccccccggcgcggacgcc
gaggggtccgagcgagaagcggagccgatccccaagatgaaggtgctggagagccccagg
aaaggcgccgcgaacgcctcggggtcgagcccagacgcccccgccaaggacgcgcgcgct
agcctgggcaccctgccgcttgggaagccccgggccggggccgcttcgccgctgaactcg
ccgctctccagcgcggtcccttctctcggcaaggagcccttcccccccagcagccccctg
cagaaggggggctccttctggagctccatccccgcctcccccgccagccgacccggctcc
ttcaccttcccgggggacagcgactccctccagcggcagacaccccgccacgcggcccct
ggcaaggatactgaccgcatgagcacgtgctcctcggccagcgagcagtccgtgcagtcc
acccagagcaacgggagtgaaagcagcagcagtagcaacatctccaccatgttggtgaca
cacgattacacggcagtgaaggaggatgagatcaacgtctaccaaggagaggtcgttcaa
attctggccagcaaccagcagaacatgtttctggtgttccgagccgccactgaccagtgc
cccgcagctgagggctggattccaggctttgtcctgggccacaccagtgcagtcatcgtg
gagaacccggacgggactctcaagaagtcaacatcttggcacacagcactccgtttaagg
aaaaaatctgagaaaaaagataaagacggcaaaagggaaggcaagttagagaacggttat
cggaagtcacgggaaggactcagcaacaaggtatctgtgaagcttctcaatcccaactac
atttatgacgttcccccagaattcgtcattccattgagtgaggtcacgtgtgagacaggg
gagaccgttgttcttagatgtcgagtctgtggccgccccaaagcctcaattacctggaag
ggccctgaacacaacaccttgaacaacgatggtcactacagcatctcctacagtgacctg
ggagaggccacgctgaagattgtgggcgtgaccacggaagatgacggcatctacacgtgc
atcgctgtcaatgacatgggttcagcctcatcgtcggccagcctgagggtcctaggtcca
gggatggatgggatcatggtgacctggaaagacaactttgactccttctacagtgaagtg
gctgagcttggcaggggcagattctctgtcgttaagaaatgtgatcagaaaggaaccaag
cgagcagtggccactaagtttgtgaacaagaagttgatgaagcgcgaccaggtcacccat
gagcttggcatcctgcagagcctccagcaccccctgcttgtcggcctcctcgacaccttt
gagacccccaccagctacatcctggtcttagaaatggctgaccagggtcgcctcctggac
tgcgtggtgcgatggggaagcctcactgaagggaagatcagggcgcacctgggggaggtt
ctggaagctgtccggtacctgcacaactgcaggatagcacacctggacctaaagcctgag
aatatcctggtggatgagagtttagccaagccaaccatcaaactggctgactttggagat
gctgttcagctcaacacgacctactacatccaccagttactggggaaccctgaattcgca
gcccctgaaatcatcctcgggaaccctgtctccctgacctcggatacgtggagtgttgga
gtgctcacatacgtacttcttagtggcgtgtcccccttcctggatgacagtgtggaagag
acctgcctgaacatttgccgcttagactttagcttcccagatgactactttaaaggagtg
agccagaaggccaaggagttcgtgtgcttcctcctgcaggaggaccccgccaagcgtccc
tcggctgcgctggccctccaggagcagtggctgcaggccggcaacggcagaagcacgggc
gtcctcgacacgtccagactgacttccttcattgagcggcgcaaacaccagaatgatgtt
cgacctatccgtagcattaaaaactttctgcagagcaggcttctgcctagagttttaatt
a

Protein Sequence

>TRIO
MKAMDVLPILKEKVAYLSGGRDKRGGPILTFPARSNHDRIRQEDLRRLISYLACIPSEEV
CKRGFTVIVDMRGSKWDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEF
ETNMVSLEGLTKVVDPSQLTPEFDGCLEYNHEEWIEIRVAFEDYISNATHMLSRLEELQD
ILAKKELPQDLEGARNMIEEHSQLKKKVIKAPIEDLDLEGQKLLQRIQSSESFPKKNSGS
GNADLQNLLPKVSTMLDRLHSTRQHLHQMWHVRKLKLDQCFQLRLFEQDAEKMFDWITHN
KGLFLNSYTEIGTSHPHAMELQTQHNHFAMNCMNVYVNINRIMSVANRLVESGHYASQQI
RQIASQLEQEWKAFAAALDERSTLLDMSSIFHQKAEKYMSNVDSWCKACGEVDLPSELQD
LEDAIHHHQGIYEHITLAYSEVSQDGKSLLDKLQRPLTPGSSDSLTASANYSKAVHHVLD
VIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKS
LHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRIQDF
VRRVEQRKILLDMSVSFHTHVKELWTWLEELQKELLDDVYAESVEAVQDLIKRFGQQQQT
TLQVTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERK
IKLELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTIAEQRLQHHADKALTMN
NLTFDVIHQGQDLLQYVNEVQASGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQH
RKHLEQCVQLRHLQAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEK
THQSALQVQQKAEAMLQANHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKT
SEQVCSVLESLEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARR
NADVFLKYLHRNSVNMPGMVTHIKAPEQQVKNILNELFQRENRVLHYWTMRKRRLDQCQQ
YVVFERSAKQALEWIHDNGEFYLSTHTSTGSSIQHTQELLKEHEEFQITAKQTKERVKLL
IQLADGFCEKGHAHAAEIKKCVTAVDKRYRDFSLRMEKYRTSLEKALGISSDSNKSSKSL
QLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYL
WEMTSGVEEIPPGIVNKELIIFGNMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADK
FQMYVTYCKNKPDSTQLILEHAGSYFDEIQQRHGLANSISSYLIKPVQRITKYQLLLKEL
LTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSMLEGFDENIESQGELILQESFQVWDPKT
LIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEGDPCKFALWV
GRTPTSDNKIVLKASSIENKQDWIKHIREVIQERTIHLKGALKEPIHIPKTAPATRQKGR
RDGEDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCELTVVIHDFTACNSNELTIRR
GQTVEVLERPHDKPDWCLVRTTDRSPAAEGLVPCGSLCIAHSRSSMEMEGIFNHKDSLSV
SSNDASPPASVASLQPHMIGAQSSPGPKRPGNTLRKWLTSPVRRLSSGKADGHVKKLAHK
HKKSREVRKSADAGSQKDSDDSAATPQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEE
GEEGADAVPLPPPMAIQQHSLLQPDSQDDKASSRLLVRPTSSETPSAAELVSAIEELVKS
KMALEDRPSSLLVDQGDSSSPSFNPSDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVE
TERDYVRDLGYVVEGYMALMKEDGVPDDMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLE
DPEKLGSLFVKHERRLHMYIAYCQNKPKSEHIVSEYIDTFFEDLKQRLGHRLQLTDLLIK
PVQRIMKYQLLLKDFLKYSKKASLDTSELERAVEVMCIVPRRCNDMMNVGRLQGFDGKIV
AQGKLLLQDTFLVTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIK
VSCLCLEENVENDPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILENQRNFLNA
LTSPIEYQRNHSGGGGGGGSGGSGGGGGSGGGGAPSGGSGHSGGPSSCGGAPSTSRSRPS
RIPQPVRHHPPVLVSSAASSQAEADKMSGTSTPGPSLPPPGAAPEAGPSAPSRRPPGADA
EGSEREAEPIPKMKVLESPRKGAANASGSSPDAPAKDARASLGTLPLGKPRAGAASPLNS
PLSSAVPSLGKEPFPPSSPLQKGGSFWSSIPASPASRPGSFTFPGDSDSLQRQTPRHAAP
GKDTDRMSTCSSASEQSVQSTQSNGSESSSSSNISTMLVTHDYTAVKEDEINVYQGEVVQ
ILASNQQNMFLVFRAATDQCPAAEGWIPGFVLGHTSAVIVENPDGTLKKSTSWHTALRLR
KKSEKKDKDGKREGKLENGYRKSREGLSNKVSVKLLNPNYIYDVPPEFVIPLSEVTCETG
ETVVLRCRVCGRPKASITWKGPEHNTLNNDGHYSISYSDLGEATLKIVGVTTEDDGIYTC
IAVNDMGSASSSASLRVLGPGMDGIMVTWKDNFDSFYSEVAELGRGRFSVVKKCDQKGTK
RAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGLLDTFETPTSYILVLEMADQGRLLD
CVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLDLKPENILVDESLAKPTIKLADFGD
AVQLNTTYYIHQLLGNPEFAAPEIILGNPVSLTSDTWSVGVLTYVLLSGVSPFLDDSVEE
TCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQEDPAKRPSAALALQEQWLQAGNGRSTG
VLDTSRLTSFIERRKHQNDVRPIRSIKNFLQSRLLPRVLI

  • Gold
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  • Bronze
  • IntAct