---

Cellular Component

---

GO ID	Description
GO:0005737	cytoplasm
GO:0030027	lamellipodium
GO:0005829	cytosol
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0005911	cell-cell junction
GO:0005886	plasma membrane
GO:0048471	perinuclear region of cytoplasm
GO:0042995	cell projection
GO:0030054	cell junction

---

Molecular Function

---

GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0004871	signal transducer activity

---

Biological Process

---

GO ID	Description
GO:0043542	endothelial cell migration
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0043065	positive regulation of apoptotic process
GO:0007165	signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0035767	endothelial cell chemotaxis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling

---

Reactome

---

Reactome ID	Description
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-194840	Rho GTPase cycle
R-HSA-193648	NRAGE signals death through JNK

---

KEGG

---

Kegg ID	Description
hsa05200	Pathways in cancer

---

Field	Data
Localization in this study:	plasma_membrane
Localization in the literature:	plasma membrane plasma membrane, vesicles