Field Data
UniProt Accession: O94988
Gene Name: FAM13A
Gene Synonim: FAM13A1, KIAA0914
GAP/GEF: GAP
Description: Protein FAM13A
Keywords: Alternative splicing;Coiled coil;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 10144
Ensembl Gene ID: ENSG00000138640
Ensembl Protein ID: ENSP00000423252
Our Specificity Rac1
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: nucleus

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>FAM13A
atgggggcaggagctctagccatctgtcaaagtaaagcagcggttcggctgaaagaagac
atgaaaaagatagtggcagtgccattaaatgaacagaaggattttacctatcagaagtta
tttggagtcagtctccaagaacttgaacggcaggggctcaccgagaatggcattccagca
gtagtgtggaatatagtggaatatttgacgcagcatggacttacccaagaaggtcttttt
agggtgaatggtaacgtgaaggtggtggaacaacttcgactgaagttcgagagtggagtg
cccgtggagctcgggaaggacggtgatgtctgctcagcagccagtctgttgaagctgttt
ctgagggagctgcctgacagtctgatcacctcagcgttgcagcctcgattcattcaactc
tttcaggatggcagaaatgatgttcaggagagtagcttaagagacttaataaaagagctg
ccagacacccactactgcctcctcaagtacctttgccagttcttgacaaaagtagccaag
catcatgtgcagaatcgcatgaatgttcacaatctcgccactgtatttgggccaaattgc
tttcatgtgccacctgggcttgaaggcatgaaggaacaggacctgtgcaacaagataatg
gctaaaattctagaaaattacaataccctgtttgaagtagagtatacagaaaatgatcat
ctgagatgtgaaaacctggctaggcttatcatagtaaaagaggtctattataagaactcc
ctgcccatccttttaacaagaggcttagaaagagacatgccaaaaccacctccaaaaacc
aagatcccaaaatccaggagtgagggatctattcaggcccacagagtactgcaaccagag
ctatctgatggcattcctcagctcagcttgcggctaagttatagaaaagcctgcttggaa
gacatgaattcagcagagggtgctattagtgccaagttggtacccagttcacaggaagat
gaaagacctctgtcacctttctatttgagtgctcatgtaccccaagtcagcaatgtgtct
gcaaccggagaactcttagaaagaaccatccgatcagctgtagaacaacatctttttgat
gttaataactctggaggtcaaagttcagaggactcagaatctggaacactatcagcatct
tctgccacatctgccagacagcgccgccgccagtccaaggagcaggatgaagttcgacat
gggagagacaagggacttatcaacaaagaaaatactccttctgggttcaaccaccttgat
gattgtattttgaatactcaggaagtcgaaaaggtacacaaaaatacttttggttgtgct
ggagaaaggagcaagcctaaacgtcagaaatccagtactaaactttctgagcttcatgac
aatcaggacggtcttgtgaatatggaaagtctcaattccacacgatctcatgagagaact
ggacctgatgattttgaatggatgtctgatgaaaggaaaggaaatgaaaaagatggtgga
cacactcagcattttgagagccccacaatgaagatccaggagcatcccagcctatctgac
accaaacagcagagaaatcaagatgccggtgaccaggaggagagctttgtctccgaagtg
ccccagtcggacctgactgcattgtgtgatgaaaagaactgggaagagcctatccctgct
ttctcctcctggcagcgggagaacagtgactctgatgaagcccacctctcgccgcaggct
gggcgcctgatccgtcagctgctggacgaagacagcgaccccatgctctctcctcggttc
tacgcttatgggcagagcaggcaatacctggatgacacagaagtgcctccttccccacca
aactcccattctttcatgaggcggcgaagctcctctctggggtcctatgatgatgagcaa
gaggacctgacacctgcccagctcacacgaaggattcagagccttaaaaagaagatccgg
aagtttgaagatagattcgaagaagagaagaagtacagaccttcccacagtgacaaagca
gccaatccggaggttctgaaatggacaaatgaccttgccaaattccggagacaacttaaa
gaatcaaaactaaagatatctgaagaggacctaactcccaggatgcggcagcgaagcaac
acactccccaagagttttggttcccaacttgagaaagaagatgagaagaagcaagagctg
gtggataaagcaataaagcccagtgttgaagccacattggaatctattcagaggaagctc
caggagaagcgagcggaaagcagccgccctgaggacattaaggatatgaccaaagaccag
attgctaatgagaaagtggctctgcagaaagctctgttatattatgaaagcattcatgga
cggccggtaacaaagaacgaacggcaggtgatgaagccactatacgacaggtaccggctg
gtcaaacagatcctctcccgagctaacaccatacccatcattggttccccctccagcaag
cggagaagccctttgctgcagccaattatcgagggcgaaactgcttccttcttcaaggag
ataaaggaagaagaggaggggtcagaagacgatagcaatgtgaagccagacttcatggtc
actctgaaaaccgatttcagtgcacgatgctttctggaccaattcgaagatgacgctgat
ggatttatttccccaatggatgataaaataccatcaaaatgcagccaggacacagggctt
tcaaatctccatgctgcctcaatacctgaactcctggaacacctccaggaaatgagagaa
gaaaagaaaaggattcgaaagaaacttcgggattttgaagacaactttttcagacagaat
ggaagaaatgtccagaaggaagaccgcactcctatggctgaagaatacagtgaatataag
cacataaaggcgaaactgaggctcctggaggtgctcatcagcaagagagacactgattcc
aagtccatgttaatta

Protein Sequence

>FAM13A
MGAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENGIPA
VVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKLF
LRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVAK
HHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILENYNTLFEVEYTENDH
LRCENLARLIIVKEVYYKNSLPILLTRGLERDMPKPPPKTKIPKSRSEGSIQAHRVLQPE
LSDGIPQLSLRLSYRKACLEDMNSAEGAISAKLVPSSQEDERPLSPFYLSAHVPQVSNVS
ATGELLERTIRSAVEQHLFDVNNSGGQSSEDSESGTLSASSATSARQRRRQSKEQDEVRH
GRDKGLINKENTPSGFNHLDDCILNTQEVEKVHKNTFGCAGERSKPKRQKSSTKLSELHD
NQDGLVNMESLNSTRSHERTGPDDFEWMSDERKGNEKDGGHTQHFESPTMKIQEHPSLSD
TKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQA
GRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQ
EDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQLK
ESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRKL
QEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYRL
VKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFMV
TLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMRE
EKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRDTDS
KSMLI

  • Gold
  • Silver
  • Bronze
  • IntAct