Field Data
UniProt Accession: O94989
Gene Name: ARHGEF15
Gene Synonim: KIAA0915
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)
Keywords: Cell projection;Complete proteome;GTPase activation;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome;Ubl conjugation
Entrez ID: 22899
Ensembl Gene ID: ENSG00000198844
Ensembl Protein ID: ENSP00000412505
Our Specificity Cdc42, RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0042995cell projection
GO:0030425dendrite

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0051496positive regulation of stress fiber assembly
GO:2000297negative regulation of synapse maturation
GO:0050790regulation of catalytic activity
GO:0035023regulation of Rho protein signal transduction
GO:0061299retina vasculature morphogenesis in camera-type eye

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: actin
Localization in the literature:

Confocal Images

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF15
atgtcagcccagtcccttcctgcagcaacaccccccacgcagaagccccctcggatcatc
cgcccccgccctccttctcgttccagggctgcccagtccccagggcctccccacaatggc
tcctctccacaagaactaccccgaaactccaatgatgcaccaaccccaatgtgcaccccc
atcttctgggagcccccagctgcatccctcaagccccctgctcttttgcccccctcagct
tctagagccagcctcgactcccagacttccccagactcaccttccagcacccccacacct
agtccagtgtcccggcgctccgcctccccagaacctgctccccggtctccagtcccccca
cccaagccgtctgggtcaccctgcacgcctctgctccccatggctggagtcctggctcag
aatggctctgcctcagctcctggcactgtgcggaggctggctggcaggtttgaagggggt
gctgaaggccgggctcaggatgcagatgccccggagccaggtctccaagcgagagcagat
gtgaatggggagagagaagctcccctcaccgggagtgggtcccaggagaacggtgctcca
gatgctggcctggcctgccctccctgctgcccctgtgtctgccacaccacccggcctggc
ctggagctcagatgggtgcctgtggggggctatgaggaggtccccagggtcccccgtcgg
gcctccccgctgcggacctctcgctcccgcccccaccctccaagcatcggtcaccctgcc
gttgtcctcacatcctaccgctccactgctgagcgcaaactcctgccactcctcaagcct
cccaaaccaactcgtgtcaggcaggatgccaccattttcggggaccccccacagccagat
cttgatctgctttctgaagatggaatccaaacaggggacagtcctgatgaagctcctcag
aatactcctccagcaactgtggaggggagggaagaggaggggctagaggtgctgaaggag
cagaattgggagctgcccctgcaggatgaacctctgtaccagacctaccgagcagccgtg
ctgtcagaggagctgtggggggtgggtgaggatgggagtccttctccagcaaatgctgga
gatgcacccaccttcccacgaccccctggacctcgcaacaccctgtggcaggagcttccg
gctgtgcaagccagcggtcttctggataccctcagcccccaggagaggcgcatgcaggag
agtcttttcgaggtggtgacgtccgaggcttcctacctgcgctccctgcggctgctgacc
gacaccttcgtgctgagccaggcactccgggacacgctcaccccccgtgatcaccacaca
ctcttctccaatgtgcagcgagtccagggagtcagcgagcggtttctagcaacgctcctg
tcccgtgtgcgctcttccccccacatcagcgacttgtgtgatgtggtgcatgcccacgct
gtggggcctttctcggtgtatgtggattatgtgcggaaccagcagtatcaggaggagacc
tacagccgcctcatggacaccaacgtgcgcttctccgccgagctgcgccggctgcagagc
ctccctaagtgtgagcggctcccgctgccgtccttcctgctactgcccttccagcgcatc
acccggctgcgcatgctgctgcagaatatcctgcgccagacagaagaggggtccagccgt
caggagaatgcccagaaggccctgggtgctgtcagcaagatcatcgagcgttgcagcgct
gaggtggggcgcatgaagcagactgaagagctgatccggctcacccaaaggctgcgcttc
cacaaagtcaaggccctgcccctggtctcctggtcacggcgcctggaattccagggagag
ctgactgagttagggtgccggagggggggcgtgctctttgcctcgcgcccccgcttcacc
cctctttgcctgctgctctttagcgacctgctgctcatcactcagcctaagagtgggcag
cggttacaggttctggactatgcccatcgctccctggtccaggcccagcaggttccggat
ccatctggaccccctaccttccgcctctcccttctcagcaaccaccagggccgccccacc
caccgactactccaagcttcttccctatcagacatgcagcgctggctgggagccttccca
accccaggcccccttccctgctccccagacaccatctatgaggactgtgactgttcccag
gaactgtgttcagagtcgtctgcacctgccaagactgaaggacggagtctggagtccagg
gctgcccccaaacacctgcacaagacccctgaaggttggctgaaggggcttcctggggcc
ttccctgcccagctggtgtgtgaagtcacaggggaacacgaaaggaggaggcaccttcgc
cagaaccagaggcttctcgaggctgttggaccttcttcaggcacccccaatgccccccca
cccttaatta

Protein Sequence

>ARHGEF15
MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTP
IFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPP
PKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARAD
VNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRR
ASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPD
LDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAV
LSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQE
SLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLL
SRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQS
LPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSA
EVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFT
PLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPT
HRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESR
AAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGPSSGTPNAPP
PLI

  • Gold
  • Silver
  • Bronze
  • IntAct