Field Data
UniProt Accession: P10911
Gene Name: MCF2
Gene Synonim: DBL
GAP/GEF: GEF
Description: Proto-oncogene DBL (Proto-oncogene MCF-2) [Cleaved into: MCF2-transforming protein; DBL-transforming protein]
Keywords: Alternative splicing;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Proto-oncogene;Reference proteome
Entrez ID: 4168
Ensembl Gene ID: ENSG00000101977
Ensembl Protein ID: ENSP00000438155
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0005829cytosol
GO:0016020membrane
GO:0070062extracellular exosome

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:1990830cellular response to leukemia inhibitory factor
GO:0043547positive regulation of GTPase activity
GO:0016358dendrite development
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction
GO:0035556intracellular signal transduction

Reactome

Reactome ID Description
R-HSA-193634Axonal growth inhibition (RHOA activation)
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: basal_membrane_filaments, plasma_membrane, vesicles
Localization in the literature: plasma membrane endomembranes

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>MCF2
atgcaagacatcgccttcttgtctggtggccggggaaaggacaatgcttggatcattacg
tttccagaaaactgtaattttagatgtataccagaggaagtaatagcaaaagtacttact
tacctgacatctattgcaaggcaaaatggatcagactcccggtttaccattattctggat
cgaagattggatacatggtcttctctcaaaatctctctccaaaaaatctcggcttccttc
cctgggaacttgcacttggttttggttttacgtcctaccagctttcttcaacgaacgttc
acagacattggattttggtttagtcaggaggattttatgcttaaattaccagttgttatg
ctgagctcagttagtgatttgctgacatacattgatgacaagcaattaacccctgagtta
ggcggcaccttgcagtactgccacagtgaatggatcatcttcagaaatgctatagaaaat
tttgccctcacagtgaaagaaatggctcagatgttacagtcctttggaactgaactggct
gagacagaactaccagatgatattccctcaatagaagaaattctggcaattcgtgctgaa
aggtatcatctgttgaagaatgatattacagctgtaaccaaagaaggaaaaattctgcta
acaaatctggaagtgcctgacactgaaggagctgtcagttcaagactagaatgtcatcgg
caaataagtggtgactggcaaactattaataagttgctgactcaagtacatgatatggaa
acagcttttgatggattttgggaaaaacatcaattaaaaatggagcagtatctgcaacta
tggaagtttgagcaggattttcaacagcttgtgactgaagttgaatttctattaaaccaa
caagcagaactggctgatgtaacagggactatagctcaagtaaaacaaaaaataaaaaaa
ttggaaaacttagatgaaaattctcaggagctattatcaaaggcccagtttgtgatatta
catggacacaagcttgcagcaaatcaccattatgcacttgatttaatctgccagaggtgc
aatgagctacgttacctttctgatattttggttaatgagataaaagcaaaacggatacaa
ctcagcaggaccttcaaaatgcataaactcctacagcaggctcgtcaatgctgtgatgaa
ggggaatgtcttctagctaatcaggaaatagataagtttcagtctaaagaagatgctcag
aaagctctccaagacattgaaaattttcttgaaatggctctaccctttataaattatgaa
cctgaaacactgcagtatgaatttgatgtaatattatctcctgagcttaaggttcaaatg
aagactatacaactcaagcttgaaaacattcgaagtatatttgagaaccagcaggctggt
ttcaggaacctggcagataagcatgtgaggccaatccaatttgtggtacccacacctgaa
aatttggtcacatctgggacaccatttttttcatctaaacaagggaagaagacttggaga
caaaatcagagcaacttaaaaattgaagtggtgcctgattgtcaggagaagagaagttct
ggtccatcctccagtttggacaatggcaatagcttggatgttttaaagaaccacgtacta
aatgaactgatacagactgagagagtttatgttcgagaactgtatactgttttgttgggt
tatagagcggagatggataatccagagatgtttgatcttatgccacctctcctgagaaat
aaaaaggacattctctttggaaacatggcagaaatatatgaattccataacgacattttc
ttgagcagcctggaaaattgtgctcatgctccagaaagagtgggaccttgtttcctggaa
aggaaggatgattttcagatgtatgcaaaatattgtcagaataagcccagatcagaaaca
atttggaggaagtattcagaatgcgcatttttccaggaatgtcaaagaaagttaaaacac
agacttagactggattcctatttactcaaaccagtgcaacgaatcactaaatatcagtta
ttgttgaaggagctattaaaatatagcaaagactgtgaaggatctgctctgttgaagaag
gcactcgatgcaatgctggatttactgaagtcagttaatgattctatgcatcagattgca
ataaatggctatattggaaacttaaatgaactgggcaagatgataatgcaaggtggattc
agcgtttggatagggcacaagaaaggtgctacaaaaatgaaggatttggctagattcaaa
ccaatgcagcgacaccttttcttgtatgaaaaagccattgttttttgcaaaaggcgtgtt
gaaagtggagaaggctctgacagatacccgtcatacagttttaaacactgttggaaaatg
gatgaagttggaatcactgaatatgtaaaaggtgataaccgcaagtttgaaatctggtat
ggtgaaaaggaagaagtttatattgtccaggcttctaatgtagatgtgaagatgacgtgg
ctaaaagaaataagaaatattttgttgaagcagcaggaacttttgacagttaaaaaaaga
aagcaacaggatcaattaacagaacgggataagtttcagatttctcttcagcagaatgat
gaaaagcaacagggagcttttataagtactgaggaaactgaattggaacacaccagcact
gtggtggaggtctgtgaggcaattgcgtcagttcaggcagaagcaaatacagtttggact
gaggcatcacaatctgcagaaatctctgaagaacctgcggaatggtcaagcaactatttc
taccctacttatgatgaaaatgaagaagaaaataggcccctcatgagacctgtgtcggag
atggctctcctatatttaatta

Protein Sequence

>MCF2
MQDIAFLSGGRGKDNAWIITFPENCNFRCIPEEVIAKVLTYLTSIARQNGSDSRFTIILD
RRLDTWSSLKISLQKISASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVM
LSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELA
ETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHR
QISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQ
QAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRC
NELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQ
KALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAG
FRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSS
GPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRN
KKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSET
IWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKK
ALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFK
PMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWY
GEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQND
EKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYF
YPTYDENEEENRPLMRPVSEMALLYLI

  • Gold
  • Silver
  • Bronze
  • IntAct