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Cellular Component

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GO ID	Description
GO:0005829	cytosol
GO:0005911	cell-cell junction
GO:0005886	plasma membrane

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Molecular Function

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GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0001784	phosphotyrosine residue binding
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity

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Biological Process

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GO ID	Description
GO:0006909	phagocytosis
GO:0042110	T cell activation
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045785	positive regulation of cell adhesion
GO:0043065	positive regulation of apoptotic process
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046854	phosphatidylinositol phosphorylation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0031295	T cell costimulation
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0030593	neutrophil chemotaxis
GO:0030217	T cell differentiation
GO:0038111	interleukin-7-mediated signaling pathway
GO:0072593	reactive oxygen species metabolic process
GO:0008361	regulation of cell size
GO:0006955	immune response
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0048015	phosphatidylinositol-mediated signaling
GO:0030168	platelet activation
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0007229	integrin-mediated signaling pathway
GO:0006355	regulation of transcription, DNA-templated

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Reactome

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Reactome ID	Description
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-4420097	VEGFA-VEGFR2 Pathway
R-HSA-912631	Regulation of signaling by CBL
R-HSA-1257604	PIP3 activates AKT signaling
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-2871809	FCERI mediated Ca+2 mobilization
R-HSA-114604	GPVI-mediated activation cascade
R-HSA-2871796	FCERI mediated MAPK activation
R-HSA-1433557	Signaling by SCF-KIT
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-194840	Rho GTPase cycle
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-512988	Interleukin-3, 5 and GM-CSF signaling
R-HSA-389359	CD28 dependent Vav1 pathway
R-HSA-5218920	VEGFR2 mediated vascular permeability
R-HSA-193648	NRAGE signals death through JNK

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KEGG

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Kegg ID	Description
hsa04510	Focal adhesion
hsa04650	Natural killer cell mediated cytotoxicity
hsa04024	cAMP signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04062	Chemokine signaling pathway
hsa04810	Regulation of actin cytoskeleton

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Field	Data
Localization in this study:	focal_adhesions
Localization in the literature:	cytosolic focal adhesions