Field Data
UniProt Accession: P15882
Gene Name: CHN1
Gene Synonim: ARHGAP2, CHN
GAP/GEF: GAP
Description: N-chimaerin (A-chimaerin) (Alpha-chimerin) (N-chimerin) (NC) (Rho GTPase-activating protein 2)
Keywords: 3D-structure;Acetylation;Alternative splicing;Complete proteome;Disease mutation;GTPase activation;Metal-binding;Neurogenesis;Phosphoprotein;Reference proteome;SH2 domain;Zinc;Zinc-finger
Entrez ID: 1123
Ensembl Gene ID: ENSG00000128656
Ensembl Protein ID: ENSP00000386741
Our Specificity Rac1
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005070SH3/SH2 adaptor activity
GO:0046875ephrin receptor binding
GO:0046872metal ion binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0007399nervous system development
GO:0009967positive regulation of signal transduction
GO:0007165signal transduction
GO:0008045motor neuron axon guidance
GO:0035556intracellular signal transduction
GO:0043087regulation of GTPase activity
GO:0048013ephrin receptor signaling pathway
GO:0050770regulation of axonogenesis

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic, endomembranes
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>CHN1
atggccctgaccctgtttgatacagatgaatatagacctcctgtttggaaatcttactta
tatcagctacaacaggaagcccctcatcctcgaagaattacctgtacttgcgaggtggaa
aacagaccaaagtattatggaagagagtttcatggcatgatctccagagaagcagccgac
cagctcttgattgtggctgaggggagctacctcatccgggagagccagcggcagccaggg
acctacactttggctttaagatttggaagtcaaaccagaaacttcaggctctactacgat
ggcaagcactttgttggggagaaacgctttgagtccatccacgatctggtgactgatggc
ttgattactctctatattgaaaccaaggcagcagaatacattgccaagatgacgataaac
ccaatttatgagcacgtaggatacacaaccttaaacagagagccagcatacaaaaaacat
atgccagtcctgaaagagacacatgatgagagagattctacaggccaggatggggtgtca
gagaaaaggttgacatcacttgttagaagagcaactctgaaagaaaacgagcaaattcca
aaatatgaaaagattcacaatttcaaggtgcatacattcagagggccacactggtgtgaa
tactgtgccaactttatgtggggtctcattgctcagggagtgaaatgtgcagattgtggt
ttgaatgttcataagcagtgttccaagatggtcccaaatgactgtaagccagacttgaag
catgtcaaaaaggtgtacagctgtgaccttacgacgctcgtgaaagcacataccactaag
cggccaatggtggtagacatgtgcatcagggagattgagtctagaggtcttaattctgaa
ggactataccgagtatcaggatttagtgacctaattgaagatgtcaagatggctttcgac
agagatggtgagaaggcagatatttctgtgaacatgtatgaagatatcaacattatcact
ggtgcacttaaactgtacttcagggatttgccaattccactcattacatatgatgcctac
cctaagtttatagaatctgccaaaattatggatccggatgagcaattggaaacccttcat
gaagcactgaaactactgccacctgctcactgcgaaaccctccggtacctcatggcacat
ctaaagagagtgaccctccacgaaaaggagaatcttatgaatgcagagaaccttggaatc
gtctttggacccacccttatgagatctccagaactagacgccatggctgcattgaatgat
atacggtatcagagactggtggtggagctgcttatcaaaaacgaagacattttattttta
atta

Protein Sequence

>CHN1
MALTLFDTDEYRPPVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAAD
QLLIVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESIHDLVTDG
LITLYIETKAAEYIAKMTINPIYEHVGYTTLNREPAYKKHMPVLKETHDERDSTGQDGVS
EKRLTSLVRRATLKENEQIPKYEKIHNFKVHTFRGPHWCEYCANFMWGLIAQGVKCADCG
LNVHKQCSKMVPNDCKPDLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSE
GLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITYDAY
PKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGI
VFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILFLI

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