Field Data
UniProt Accession: P32019
Gene Name: INPP5B
Gene Synonim: OCRL2
GAP/GEF: GAP
Description: Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
Keywords: 3D-structure;Alternative splicing;Complete proteome;Cytoplasm;Cytoplasmic vesicle;Direct protein sequencing;Endosome;Golgi apparatus;Hydrolase;Lipoprotein;Magnesium;Membrane;Metal-binding;Methylation;Polymorphism;Prenylation;Reference proteome
Entrez ID: 3633
Ensembl Gene ID: ENSG00000204084
Ensembl Protein ID: ENSP00000362118
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0030670phagocytic vesicle membrane
GO:0005793endoplasmic reticulum-Golgi intermediate compartment
GO:0031410cytoplasmic vesicle
GO:0005829cytosol
GO:0016020membrane
GO:0005886plasma membrane
GO:0005768endosome
GO:0016021integral component of membrane
GO:0031901early endosome membrane

Molecular Function


GO ID Description
GO:0016787hydrolase activity
GO:0052658inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0005096GTPase activator activity
GO:0004439phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515protein binding
GO:0046872metal ion binding

Biological Process


GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0001701in utero embryonic development
GO:0043547positive regulation of GTPase activity
GO:0030317flagellated sperm motility
GO:0043647inositol phosphate metabolic process
GO:0007283spermatogenesis
GO:0070613regulation of protein processing
GO:0007165signal transduction
GO:0046856phosphatidylinositol dephosphorylation

Reactome


Reactome ID Description
R-HSA-1855183Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-194840Rho GTPase cycle
R-HSA-1855204Synthesis of IP3 and IP4 in the cytosol

KEGG


Kegg ID Description
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system

Field Data
Localization in this study: vesicles
Localization in the literature: vesicles

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>INPP5B
atggaccagtctgtggcaatccaggagaccctggttgagggggaatactgcgtcatcgca
gtccaaggtgtgctgtgtaagggagatagccggcagagccgcctgctcgggctggtgagg
taccggctggaaaatgacgcccaggagcatgctctcttcctgtatacacaccggaggatg
gccatcacaggagacgatgtatctctggaccagatagtgccactctcaaaagattttatg
ctggaagaagtgtccccagatggtgaactctacatccttggctctgatgtgacagtacaa
ttgaacacagctgaactcaagcttgtattccaacttccctttggttcacacaccagaacg
ttcctccaggaagtggccagagcctgtccaggtttcgaccctgagacgcgggatcccgag
ttcgagtggctgtcaagacacacatgcgcggagcccgatgccgagtcgccgaaaccgcgc
gagtggaattcggacccgggtacccggagtgggttcgcgcccattggaggaagcaggcat
cagtctcggaatgcacggcgaggattggaggatgtcttgcctaggggccctggctacatt
ctgctttggggcggagccgctgaggagccggaatttctattggcggaggagatgcatgag
ggcgggcctgtgagaggacggagaccgctcgccgggcggcgggatgaagcgcttgaggaa
gcagactgggaaatgtcggcaggcggcggctctcgggagcgcgactgtgcaggcgtttct
aacgtcgacagctcgaggccaaatgggaggggcccggaccaaccctccggagccaggtgt
ccggagaaaccagaaaactctctcacaagacagaataaatctaagtctgacatgtctgaa
aaggttcgctccgccacagtcacagtatcggacaaggctcacattttatccgtgcagaag
tttgggcttcgagacacaatcgtgagatcacacctcgtgcagaaggaagagaattatacc
tacatccagaacttcaggttttttgtgggaacctacaatgtgaacggacagtcccccaaa
gaatgtctccggccctggctgagccacagcgccctggcccccgacgtgtactgtgtaggg
ttccaggagctcgacctgagtaaggaagccttcttctttcacgataccccaaaggaggaa
gagtggtttaaggccgtgtcagaaagccttcacccagacgccaagtacgcaaaggtgaag
ttcgtccgactggttgggattatgttgctgctgtacgtcaaacaggaacatgcagcctat
atctcagaagtggaagctgagaccgtagggacaggaatcatgggaaggatgggtaacaaa
ggaggagtggcgatcaggttccagctgcacaacaccagcatctgcgttgtcaattcccat
ctggcagcccacacagaggagtacgagaggaggaaccaagactacagagacatttgttct
cgaatgcagttccctcaggtggatccgagccaaccccctctcaccattaacaagcatgat
gtgatcttgtggctgggagacctcaactacaggatagaagagctggatgtgggaaaggtg
aaaaagctcgtggaagagaaggccttccaaaccctgtatgcgcacgaccagctaaaaatc
caggtggctgccaggaccatctttgatggcttcaccgagggtgagattacattccagcct
acttacaagtacgatactggctctgacgactgggacaccagtgagaagtgtcgtgcaccg
gcctggtgtgaccgaatcctgtggaaaggaaagaacatcactcagctgagttaccagagc
cacatggccttgaagaccagtgaccacaagcctgtcagctcagtgtttgacattggggtg
agggttgtcaatgaagaactctaccggaagaccctggaggaaattgtccgctccctggat
aaaatggaaaacgccaacattccttctgtgaccctctccaagcgggagttctgttttgag
aatgtgaagtacatgcagttgcaaaccgagtccttcacgattcataatagccaagtgccc
tgtcagtttgaattcatcaacaagcctgacgaagagtcctactgtaagcagtggctgacg
gccagacccagcaagggcttcctcctgccagattcgcatgttgagattgaacttgagctt
tttgtaaataagtctactgccacaaaactcaactcaggcaaggacacgattgaagacatt
ctggttttacacttggagcggggaaaggactactttctgtctgtgtctgggaactacctg
cccagctgcttcggatctcctatccatacattgtgctacatgagggagcccatcttggat
ctaccactgaaaactgttagtgacctgacgttgatgtcagtgcagactgcagatgacagg
agccagttggagaaccccatggaaatccccaaagagctctggatgatggtggattacctg
tacagaaatgccgtccagcaggaagatctgtttcagcagccaggtctgaggccagagttt
gaccatataagggactgtctagatactgggatgatcgaccagctctgtgctaacaaccat
tctgtagccgaagccttgctgcttttcctagagagcctgccagagcctgtcatctgttac
agcgcctaccatagctgcttggagtgttctggcaattacgcagcaagcaagcagataatt
ttaaccctccccagcttccacaaaaatgtcttcaactacttgatggcgtttttgcaagaa
ctgctgaaaaattcagcaaacaatcatttggatgagaatattctagctagcatatttggc
agcttactgctccggaacccagctcgtcaccaaaagcttgacatggcggaaaagaagaag
gcccaagagtttattcaccagttcctctgcggtccactcttaatta

Protein Sequence

>INPP5B
MDQSVAIQETLVEGEYCVIAVQGVLCKGDSRQSRLLGLVRYRLENDAQEHALFLYTHRRM
AITGDDVSLDQIVPLSKDFMLEEVSPDGELYILGSDVTVQLNTAELKLVFQLPFGSHTRT
FLQEVARACPGFDPETRDPEFEWLSRHTCAEPDAESPKPREWNSDPGTRSGFAPIGGSRH
QSRNARRGLEDVLPRGPGYILLWGGAAEEPEFLLAEEMHEGGPVRGRRPLAGRRDEALEE
ADWEMSAGGGSRERDCAGVSNVDSSRPNGRGPDQPSGARCPEKPENSLTRQNKSKSDMSE
KVRSATVTVSDKAHILSVQKFGLRDTIVRSHLVQKEENYTYIQNFRFFVGTYNVNGQSPK
ECLRPWLSHSALAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLHPDAKYAKVK
FVRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSH
LAAHTEEYERRNQDYRDICSRMQFPQVDPSQPPLTINKHDVILWLGDLNYRIEELDVGKV
KKLVEEKAFQTLYAHDQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSDDWDTSEKCRAP
AWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNEELYRKTLEEIVRSLD
KMENANIPSVTLSKREFCFENVKYMQLQTESFTIHNSQVPCQFEFINKPDEESYCKQWLT
ARPSKGFLLPDSHVEIELELFVNKSTATKLNSGKDTIEDILVLHLERGKDYFLSVSGNYL
PSCFGSPIHTLCYMREPILDLPLKTVSDLTLMSVQTADDRSQLENPMEIPKELWMMVDYL
YRNAVQQEDLFQQPGLRPEFDHIRDCLDTGMIDQLCANNHSVAEALLLFLESLPEPVICY
SAYHSCLECSGNYAASKQIILTLPSFHKNVFNYLMAFLQELLKNSANNHLDENILASIFG
SLLLRNPARHQKLDMAEKKKAQEFIHQFLCGPLLI

  • Gold
  • Silver
  • Bronze
  • IntAct