Field Data
UniProt Accession: P42331
Gene Name: ARHGAP25
Gene Synonim: KIAA0053
GAP/GEF: GAP
Description: Rho GTPase-activating protein 25 (Rho-type GTPase-activating protein 25)
Keywords: 3D-structure;Alternative splicing;Coiled coil;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 9938
Ensembl Gene ID: ENSG00000163219
Ensembl Protein ID: ENSP00000417139
Our Specificity
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol
GO:0001891phagocytic cup

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0007015actin filament organization
GO:0043547positive regulation of GTPase activity
GO:0051056regulation of small GTPase mediated signal transduction
GO:0051058negative regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0006911phagocytosis, engulfment

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP25
atgtccctcggtcagtcggcctgtctgttcctctctatagctcggtcaaggagtgtgatg
actggcgagcagatggctgccttccatccatcgtccacccccaacccgctggagaggccc
atcaagatgggctggctgaagaagcagaggtccatcgtgaagaactggcagcagaggtac
tttgtgctgagggcgcagcagctctactactacaaggatgaagaggacacgaagccccag
ggctgcatgtatctaccaggatgtacaatcaaggagatcgccacaaacccagaagaagct
gggaagtttgtctttgaaatcattccagcctcatgggaccagaatcgcatgggacaggac
tcctatgtcctcatggccagctctcaggcggagatggaggagtgggttaaattcctcagg
agagttgctggcacaccctgtggagtgtttggccagcgcttggatgagactgtggcctat
gaacagaaattcggcccccatctggtgcccatcctggtggagaaatgtgcagagttcatc
ctggagcacggccggaatgaagagggcatcttccgtctgcctgggcaggacaacctggtg
aagcagctgagagacgcttttgatgctggggagcggccctcctttgacagagacacagat
gtgcacactgtggcttccctgttaaagctctacctccgagacctcccagagcccgtggtt
ccctggagccagtacgaagggttcctgctctgtgggcagctcacgaatgcggatgaggca
aaggctcagcaggagttgatgaagcagctctccatccttcctcgtgacaactatagtctc
ctgagctacatctgcaggttcctacatgaaatacagctgaactgtgctgttaacaagatg
agtgtggacaacctggctactgtgattggtgtgaatctcatcaggtcgaaggtcgaagac
cctgccgtgatcatgagagggactcctcagatccaaagagtgatgactatgatgatcaga
gaccatgaagtcctcttccccaagtccaaggatatacccctgtcaccccctgcccagaaa
aatgaccccaagaaagctccagtggcccgaagctctgtaggctgggatgccactgaagac
ctccgaatttctaggacagacagcttcagtagcatgacaagcgactctgatacaaccagc
cccaccggacagcagccgagcgatgcgtttccggaggacagcagcaaagtacccagggaa
aagccaggagactggaaaatgcaatctcgtaaaaggactcaaacactccctaaccggaaa
tgtttcttgacatcagcttttcagggtgccaacagcagcaaaatggagatctttaaaaat
gaattctggtcgccttcctcagaggctaaggcaggggaagggcacaggagaacgatgtct
caagacttgcgccaactttctgactcccaacggacttccacctacgataacgtcccttcc
ctgccagggtcccctggggaggaagccagtgcactctcttcccaagcctgtgactccaag
ggagatactcttgccagtccaaactctgaaactgggcctggaaaaaagaactctggagaa
gaggaaattgattctttgcagaggatggtccaagagctacgaaaggaaatagaaacacag
aagcaaatgtatgaggaacagattaaaaaccttgagaaggaaaattatgacgtttgggct
aaagtggtgaggctcaatgaagaactggagaaggaaaagaagaagtctgcagccctagag
atcagcctccgcaacatggagcgctcccgggaggatgttgagaagaggaacaaggccttg
gaagaagaagtcaaggaatttgtcaaatccatgaaggaacccaagaccgaggctttaatt
a

Protein Sequence

>ARHGAP25
MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRY
FVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQD
SYVLMASSQAEMEEWVKFLRRVAGTPCGVFGQRLDETVAYEQKFGPHLVPILVEKCAEFI
LEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVV
PWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKM
SVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQK
NDPKKAPVARSSVGWDATEDLRISRTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPRE
KPGDWKMQSRKRTQTLPNRKCFLTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMS
QDLRQLSDSQRTSTYDNVPSLPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSGE
EEIDSLQRMVQELRKEIETQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALE
ISLRNMERSREDVEKRNKALEEEVKEFVKSMKEPKTEALI

  • Gold
  • Silver
  • Bronze
  • IntAct