Field Data
UniProt Accession: P52757
Gene Name: CHN2
Gene Synonim: ARHGAP3, BCH
GAP/GEF: GAP
Description: Beta-chimaerin (Beta-chimerin) (Rho GTPase-activating protein 3)
Keywords: 3D-structure;Alternative splicing;Complete proteome;GTPase activation;Membrane;Metal-binding;Polymorphism;Reference proteome;SH2 domain;Zinc;Zinc-finger
Entrez ID: 1124
Ensembl Gene ID: ENSG00000106069
Ensembl Protein ID: ENSP00000394284
Our Specificity Rac1
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane

Molecular Function

GO ID Description
GO:0005070SH3/SH2 adaptor activity
GO:0046872metal ion binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0009967positive regulation of signal transduction
GO:0007165signal transduction
GO:0035556intracellular signal transduction
GO:0043087regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>CHN2
atggcagcgtccagcaactccagcctgtccggctcgtcggtgtcctccgatgctgaagaa
taccagcctcctatatggaaatcatacttatatcagttacagcaagaggcacctcgtccc
aagagaatcatttgtcctcgggaggtggaaaacagaccaaaatattatggaagagagttt
catgggatcatctctcgggagcaggcggatgagcttcttggaggcgtggagggtgcctac
atccttagagaaagccagcggcaaccaggatgctacacgctggctctcaggtttggaaac
cagaccttaaactacaggctcttccacgacgggaaacactttgtgggtgagaagaggttt
gagtcgattcatgatctggtgacagatggcttgataacactgtacatagaaacaaaagct
gccgagtacatttcaaaaatgacaactaaccccatctatgaacacattggatatgccacc
ctactcagagaaaaagtatccagaaggctgagcaggtctaaaaatgaaccaagaaaaaca
aacgtcacacatgaagaacacacagcggtggaaaagatctcctccctggttcgaagggct
gccctcacacacaacgacaaccacttcaattatgagaagacacacaactttaaggtccac
acgttccgaggcccacactggtgtgaatattgtgccaatttcatgtgggggctcatcgcc
caaggggtccggtgctcagactgtggattgaacgtacacaaacagtgttccaagcacgtt
cccaatgactgccaacctgatctcaagaggatcaagaaagtgtactgttgtgacctcaca
acacttgtgaaggctcacaacactcagagacccatggtggtagacatatgcattcgggaa
attgaagcaagaggattaaaatcggaaggcctttacagagtctctgggttcactgaacac
attgaagatgtcaaaatggcatttgacagagatggtgaaaaggccgatatatctgccaat
gtctatccagacataaacatcatcactggagcccttaaactgtatttcagagacttaccc
atccctgtcatcacatatgatacctattccaaatttatagatgcagcaaaaatctccaat
gcagatgagaggctggaagccgtccatgaagtgctgatgctgctgcctcctgcccactat
gaaaccctccggtacctaatgatccacctcaaaaaggttactatgaatgaaaaagacaat
ttcatgaatgcagaaaatctggggatcgtgtttgggcccactctgatgaggccccctgag
gacagcaccctgaccaccctgcatgatatgcggtaccaaaagctgattgtgcagatttta
atagaaaacgaagacgttttattct

Protein Sequence

>CHN2
MAASSNSSLSGSSVSSDAEEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREF
HGIISREQADELLGGVEGAYILRESQRQPGCYTLALRFGNQTLNYRLFHDGKHFVGEKRF
ESIHDLVTDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKVSRRLSRSKNEPRKT
NVTHEEHTAVEKISSLVRRAALTHNDNHFNYEKTHNFKVHTFRGPHWCEYCANFMWGLIA
QGVRCSDCGLNVHKQCSKHVPNDCQPDLKRIKKVYCCDLTTLVKAHNTQRPMVVDICIRE
IEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLP
IPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDN
FMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIENEDVLF

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