Field Data
UniProt Accession: P85298
Gene Name: ARHGAP8
Gene Synonim:
GAP/GEF: GAP
Description: Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Polymorphism;Reference proteome
Entrez ID: 23779
Ensembl Gene ID: ENSG00000241484
Ensembl Protein ID: ENSP00000374424
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0070374positive regulation of ERK1 and ERK2 cascade
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ARHGAP8
atggctggcctggaccccacactgagcacaagtcacccattctatgatgtggccagacac
ggcatcctgcaggtggcaggggatgaccgccaggggagacgcatcttcactttcagctgc
tgccggctgccacccttgcaccagctcaaccaccagcgcctgctggagtatctgaagtac
acactggaccagcatgtggagaacgactatactattgtctactttcactatggcctcagc
agccagaacaaaccatccctaggctggctccagaacacctacaaggagtttgaccggaag
tacaagaagaacctgaaggcactgtacgttgtacaccccaccagcctcatcaaagcactg
tggaacatcttcaagcccctcatcagtcacaagtttgggaaaaaagtcacctactgcagc
aacctgcgtgagctccgagaacaccttcagtgcgaccagctgctcatccccccggaagta
gtgcggtatgacgagaaactgcaaaacctgcacaaaggtcaaccgcccccgcccaccaag
acaccgccacctcggccgcctctgcccacccagcagtttggcgtcagcctgcaatacctc
agagacaaaaatcaaggtgaactcatccccccggtgctgcgttggacggtgacatatctg
agagaaaaaggactgcgcactgagggcctgttccggagatcggccagcgcccagactgtc
cgtcaggtgcagcggctatatgatcaagggaagcccgtgaactttgatgattatggagac
atgcacctcccagccgtgatcctgaagacatttctccgagagctgccccagccactgctg
accttccaagcctacgagcagattctcgggatcaccagtgtggagagcagccttcgagtg
acccactgccgcctgatcctgcggagcctcccagaacacaactatgccgtactccgctac
ctcatgggcttcctgcatgaagtgtctctggagagcatttcaaacaagatgaacagctct
aacctggcgtgcgtgtttggattgaacttgatctggccatcccagggggtggcttccctg
agcgccctggtacctctgaacttgttcacagagctgctgatagagtactatgacaaagtc
ttcagttgccaggaggcccctggggagcacacccgggatactgtggaagtacagcaggct
ggccctgttaccaaagaatttatgaagacgggcactccccgggcctcaccatacctgtcc
cgcctccgtatctccttaatta

Protein Sequence

>ARHGAP8
MAGLDPTLSTSHPFYDVARHGILQVAGDDRQGRRIFTFSCCRLPPLHQLNHQRLLEYLKY
TLDQHVENDYTIVYFHYGLSSQNKPSLGWLQNTYKEFDRKYKKNLKALYVVHPTSLIKAL
WNIFKPLISHKFGKKVTYCSNLRELREHLQCDQLLIPPEVVRYDEKLQNLHKGQPPPPTK
TPPPRPPLPTQQFGVSLQYLRDKNQGELIPPVLRWTVTYLREKGLRTEGLFRRSASAQTV
RQVQRLYDQGKPVNFDDYGDMHLPAVILKTFLRELPQPLLTFQAYEQILGITSVESSLRV
THCRLILRSLPEHNYAVLRYLMGFLHEVSLESISNKMNSSNLACVFGLNLIWPSQGVASL
SALVPLNLFTELLIEYYDKVFSCQEAPGEHTRDTVEVQQAGPVTKEFMKTGTPRASPYLS
RLRISLI

  • Gold
  • Silver
  • Bronze
  • IntAct