Field Data
UniProt Accession: P98171
Gene Name: ARHGAP4
Gene Synonim: KIAA0131, RGC1, RHOGAP4
GAP/GEF: GAP
Description: Rho GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (Rho-type GTPase-activating protein 4) (p115)
Keywords: 3D-structure;Alternative splicing;Coiled coil;Complete proteome;Cytoplasm;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 393
Ensembl Gene ID: ENSG00000089820
Ensembl Protein ID: ENSP00000359045
Our Specificity Rac1
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0005829cytosol
GO:0005874microtubule
GO:0030426growth cone

Molecular Function

GO ID Description
GO:0005070SH3/SH2 adaptor activity
GO:0048365Rac GTPase binding
GO:0005096GTPase activator activity
GO:0042802identical protein binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0030336negative regulation of cell migration
GO:0007010cytoskeleton organization
GO:0043547positive regulation of GTPase activity
GO:0007399nervous system development
GO:0051056regulation of small GTPase mediated signal transduction
GO:0009967positive regulation of signal transduction
GO:0007165signal transduction
GO:0030517negative regulation of axon extension
GO:0007266Rho protein signal transduction
GO:0010764negative regulation of fibroblast migration

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: Golgi, tubulin

Confocal Images

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Cytochalasin D Screen Positive

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP4
atggccgctcacgggaagctgcggcgggagcgggggctgcaggctgagtatgagacgcaa
gtcaaagagatgcgctggcagctgagcgagcagctgcgctgcctggagctgcagggcgag
ctgcggcgggagttgctgcaggagctggcagagttcatgcggcgccgcgctgaggtggag
ctggaatactcccggggcctggaaaagctggccgagcgcttctccagccgtggaggccgc
ctggggagcagccgggagcaccaaagcttccggaaggagccgtccctcctgtcgcccttg
cactgctgggcggtgctgctgcagcacacgcggcagcagagccgggagagcgcggccctg
agtgaggtgctggccgggcccctggcccagcgcctgagtcacattgcagaggacgtgggg
cgcctggtcaagaagagcagggatctggagcagcagctgcaggatgagctcctggaggtg
gtctcagagctccagacggccaagaagacgtaccaggcatatcacatggagagcgtgaat
gccgaggccaagctccgggaggccgagcggcaggaggagaagcgggcaggccggagtgtc
cccaccaccaccgctggtgccactgaggcagggcccctccgcaagagctccctcaagaag
ggagggaggctggtggagaagctctggcccccgcagaggcctgtggccgcttccagctgt
gcacctgtgtgctggctccaagctgggtttctcgtgcaccctccatggtggggtgccatg
tgcgcaccttccactcatcagcggcaggccaagttcatggagcacaaactcaagtgcaca
aaggcgcgcaacgagtacctgcttagcctggctagtgtcaacgctgctgtcagtaactac
tacctgcatgacgtcttggacctcatggactgctgtgacacagggttccacctggccctg
gggcaggtgctccggagctacacggccgctgagagccgcacccaagcctcccaagtgcag
ggcctgggcagcctggaagaagctgtggaggccctggatcctccaggggacaaagccaag
gttctcgaggtgcatgctaccgtcttctgtcccccgctgcgctttgactaccacccccat
gatggggatgaggtggctgagatctgcgttgaaatggagctgcgggacgagattctgccc
agagcccagaacatccagagccgcctggaccgacagaccattgagacagaggaggtgaac
aagactctgaaggcgacactgcaggccctgctggaggtggtggcctcggatgacggggat
gtgcttgattccttccagaccagcccctccaccgagtccctcaagtccaccagctcagac
ccaggcagccggcaggcgggccggaggcgcggccagcagcaggagaccgaaaccttctac
ctcacgaagctccaggagtatctgagtggacggagcatcctcgccaagctgcaggccaag
cacgagaagctgcaggaggcccttcagcgaggtgacaaggaggagcaggaggtgtcttgg
acccagtacacacagagaaaattccagaagagccgccagccccgccccagctcccagtat
aaccagagactctttgggggagacatggagaagtttatccagagctcaggccagcctgtg
cccctggtggtggagagctgcattcgcttcatcaacctcaatggcctgcagcatgaaggc
atcttccgggtatcgggtgcccagctccgggtctcagagatccgtgatgccttcgagaga
ggggaggacccactggtggagggctgcactgcccacgacctggactcggtggccggggtg
ctgaagctctacttccggagcctggagcccccactcttccccccagacctgttcggcgag
ctgctggcttcttcggagctggaggccacagcggagagggtggagcacgtgagccgcctg
ctgtggcggctgcccgcgccggtgctggtggttctgcgctacctcttcaccttcctcaac
cacctggcccagtacagcgatgagaacatgatggacccctacaacctggccgtgtgcttc
gggcccacgctgctaccggtgcccgctgggcaggacccggtggcgctgcagggccgggtg
aaccagctggtgcagacgctcatagtgcagcccgatcgggtcttcccgcccctgacctcg
ctgcctggccccgtctacgagaagtgcatggcaccgccttccgccagctgcctgggggac
gcccagctggagagcctgggggcggacaatgagccggagctggaagccgagatgcccgca
caggaggatgacctggagggggtcgtggaggctgtggcctgctttgcctacacgggccgc
acagcccaggagctgagcttccggcggggggacgtactgcggctgcacgagagggcctcg
agcgactggtggcggggggagcacaacggcatgcggggcctcatcccccacaagtatatc
acgctgcccgccgggacggagaagcaggtggtgggcgcagggctgcagactgcaggggag
tctgggagcagtcccgagggcctcctggcatcggagctggtccaccggccagagccatgc
acctcacctgaggccatgggaccctctggacacagacgacgctgcttggtcccagcctcc
ccagagcaacacgtggaggtggataaggctgtggcacagaacatggactctgtgtttaag
gagctcttgggaaagacctctgtccgccagggccttgggccagcatctaccacctctccc
agtcctgggccccgaagcccaaaggccccgcccagcagccgcctgggcaggaacaaaggc
ttctcccggggccctggggccccagcctcaccctcagcttcccacccccagggcctagac
acgacccccaagccacacttaatta

Protein Sequence

>ARHGAP4
MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE
LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL
SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN
AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKLWPPQRPVAASSC
APVCWLQAGFLVHPPWWGAMCAPSTHQRQAKFMEHKLKCTKARNEYLLSLASVNAAVSNY
YLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQGLGSLEEAVEALDPPGDKAK
VLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILPRAQNIQSRLDRQTIETEEVN
KTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSDPGSRQAGRRRGQQQETETFY
LTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSWTQYTQRKFQKSRQPRPSSQY
NQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEGIFRVSGAQLRVSEIRDAFER
GEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGELLASSELEATAERVEHVSRL
LWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCFGPTLLPVPAGQDPVALQGRV
NQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGDAQLESLGADNEPELEAEMPA
QEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASSDWWRGEHNGMRGLIPHKYI
TLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPCTSPEAMGPSGHRRRCLVPAS
PEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSPSPGPRSPKAPPSSRLGRNKG
FSRGPGAPASPSASHPQGLDTTPKPHLI

  • Gold
  • Silver
  • Bronze
  • IntAct