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Cellular Component

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GO ID	Description
GO:0005737	cytoplasm
GO:0043025	neuronal cell body
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0005886	plasma membrane

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Molecular Function

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GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0017124	SH3 domain binding
GO:0005515	protein binding
GO:0003677	DNA binding
GO:0046982	protein heterodimerization activity

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Biological Process

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GO ID	Description
GO:0033081	regulation of T cell differentiation in thymus
GO:0060021	palate development
GO:0050900	leukocyte migration
GO:0007296	vitellogenesis
GO:0007165	signal transduction
GO:0035264	multicellular organism growth
GO:0035023	regulation of Rho protein signal transduction
GO:0061384	heart trabecula morphogenesis
GO:0007411	axon guidance
GO:0038128	ERBB2 signaling pathway
GO:0003344	pericardium morphogenesis
GO:1904693	midbrain morphogenesis
GO:2000973	regulation of pro-B cell differentiation
GO:0043547	positive regulation of GTPase activity
GO:0002260	lymphocyte homeostasis
GO:0061029	eyelid development in camera-type eye
GO:0001942	hair follicle development
GO:0000165	MAPK cascade
GO:0043065	positive regulation of apoptotic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0001782	B cell homeostasis
GO:0048514	blood vessel morphogenesis
GO:0051057	positive regulation of small GTPase mediated signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0042129	regulation of T cell proliferation
GO:0003007	heart morphogenesis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0007265	Ras protein signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0003209	cardiac atrium morphogenesis

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Reactome

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Reactome ID	Description
R-HSA-5654688	SHC-mediated cascade:FGFR1
R-HSA-428540	Activation of RAC1
R-HSA-5673001	RAF/MAP kinase cascade
R-HSA-1963640	GRB2 events in ERBB2 signaling
R-HSA-74751	Insulin receptor signalling cascade
R-HSA-186763	Downstream signal transduction
R-HSA-2730905	Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796	FCERI mediated MAPK activation
R-HSA-8853659	RET signaling
R-HSA-5654700	FRS-mediated FGFR2 signaling
R-HSA-5654712	FRS-mediated FGFR4 signaling
R-HSA-5654706	FRS-mediated FGFR3 signaling
R-HSA-5637810	Constitutive Signaling by EGFRvIII
R-HSA-5654704	SHC-mediated cascade:FGFR3
R-HSA-210993	Tie2 Signaling
R-HSA-193648	NRAGE signals death through JNK
R-HSA-8853338	Signaling by FGFR3 point mutants in cancer
R-HSA-1433559	Regulation of KIT signaling
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-2871809	FCERI mediated Ca+2 mobilization
R-HSA-912526	Interleukin receptor SHC signaling
R-HSA-1433557	Signaling by SCF-KIT
R-HSA-8983432	Interleukin-15 signaling
R-HSA-5655302	Signaling by FGFR1 in disease
R-HSA-74749	Signal attenuation
R-HSA-375165	NCAM signaling for neurite out-growth
R-HSA-167044	Signalling to RAS
R-HSA-2428933	SHC-related events triggered by IGF1R
R-HSA-2424491	DAP12 signaling
R-HSA-8853334	Signaling by FGFR3 fusions in cancer
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-180336	SHC1 events in EGFR signaling
R-HSA-5654693	FRS-mediated FGFR1 signaling
R-HSA-983695	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-354194	GRB2:SOS provides linkage to MAPK signaling for Integrins
R-HSA-1250196	SHC1 events in ERBB2 signaling
R-HSA-8851805	MET activates RAS signaling
R-HSA-179812	GRB2 events in EGFR signaling
R-HSA-5655291	Signaling by FGFR4 in disease
R-HSA-112412	SOS-mediated signalling
R-HSA-194840	Rho GTPase cycle
R-HSA-1250347	SHC1 events in ERBB4 signaling
R-HSA-2179392	EGFR Transactivation by Gastrin
R-HSA-5654719	SHC-mediated cascade:FGFR4
R-HSA-5655253	Signaling by FGFR2 in disease
R-HSA-5654699	SHC-mediated cascade:FGFR2

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KEGG

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Kegg ID	Description
hsa04068	FoxO signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa05211	Renal cell carcinoma
hsa05214	Glioma
hsa04630	Jak-STAT signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa05231	Choline metabolism in cancer
hsa04510	Focal adhesion
hsa04926	Relaxin signaling pathway
hsa04062	Chemokine signaling pathway
hsa01521	EGFR tyrosine kinase inhibitor resistance
hsa01522	Endocrine resistance
hsa05213	Endometrial cancer
hsa05165	Human papillomavirus infection
hsa04810	Regulation of actin cytoskeleton
hsa05160	Hepatitis C
hsa04662	B cell receptor signaling pathway
hsa04540	Gap junction
hsa05205	Proteoglycans in cancer
hsa04915	Estrogen signaling pathway
hsa05206	MicroRNAs in cancer
hsa05200	Pathways in cancer
hsa04912	GnRH signaling pathway
hsa05226	Gastric cancer
hsa05225	Hepatocellular carcinoma
hsa05224	Breast cancer
hsa04664	Fc epsilon RI signaling pathway
hsa04012	ErbB signaling pathway
hsa05221	Acute myeloid leukemia
hsa05220	Chronic myeloid leukemia
hsa05215	Prostate cancer
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04010	MAPK signaling pathway
hsa04910	Insulin signaling pathway
hsa04014	Ras signaling pathway
hsa04072	Phospholipase D signaling pathway
hsa05034	Alcoholism
hsa05223	Non-small cell lung cancer
hsa04917	Prolactin signaling pathway

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Field	Data
Localization in this study:	focal_adhesions
Localization in the literature: