Field Data
UniProt Accession: Q07960
Gene Name: ARHGAP1
Gene Synonim: CDC42GAP, RHOGAP1
GAP/GEF: GAP
Description: Rho GTPase-activating protein 1 (CDC42 GTPase-activating protein) (GTPase-activating protein rhoGAP) (Rho-related small GTPase protein activator) (Rho-type GTPase-activating protein 1) (p50-RhoGAP)
Keywords: 3D-structure;Acetylation;Complete proteome;Cytoplasm;Direct protein sequencing;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;SH3-binding
Entrez ID: 392
Ensembl Gene ID: ENSG00000175220
Ensembl Protein ID: ENSP00000310491
Our Specificity Cdc42, RhoA
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0070062extracellular exosome
GO:0005829cytosol
GO:0048471perinuclear region of cytoplasm
GO:0010008endosome membrane

Molecular Function

GO ID Description
GO:0005070SH3/SH2 adaptor activity
GO:0005096GTPase activator activity
GO:0017124SH3 domain binding
GO:0045296cadherin binding
GO:0017137Rab GTPase binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0009967positive regulation of signal transduction
GO:0032439endosome localization
GO:0098706ferric iron import across plasma membrane
GO:0007165signal transduction
GO:0033572transferrin transport
GO:0007266Rho protein signal transduction
GO:0007264small GTPase mediated signal transduction
GO:2001136negative regulation of endocytic recycling

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: vesicles
Localization in the literature: vesicles

Confocal Images

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Cytochalasin D Screen Positive

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ARHGAP1
atggaccctctctcagagctgcaagatgacctgacgctggatgacaccagccaagctctg
aaccagttgaagctggcctccattgatgagaagaactggccttctgatgaaatgccagac
ttccccaagtcagatgactccaaaagcagctctccagaacctgtgacacacctgaagtgg
gatgacccttactatgacattgcccggcaccagattgtggaagtagccggtgatgataag
tatgggcggaagatcattgtattcagtgcttgccggatgccccccagccaccagctggac
cacagcaagctcttggggtatttgaaacacacattggaccagtatgtggagagtgactac
acactcctgtacctgcaccatggcctgaccagtgacaacaagccctccctcagctggcta
cgggatgcctaccgagagtttgaccgcaagtacaagaagaacatcaaggctctgtacatc
gtgcacccaaccatgttcatcaaaactctgcttatcctctttaagcctctcatcagtttc
aagtttggacggaagatcttctacgtgaattacctgagtgagctgagcgagcacgtgaag
ctggagcagttggggatccctcgccaagtgctcaagtatgatgacttcctcaaatccaca
cagaaaagccctgcaacagctcccaagcccatgccaccacggccccccctgcccaatcag
cagtttggggtctccttacagcacctccaggagaaaagcccaggccaggagcccattccc
attgtcctcagggagaccgtcgcctacttgcaggctcacgctctcaccactgagggcatc
ttccggaggtctgccaacacccaggttgtccgggaagtgcagcagaaatacaatatgggg
ctgccggtggactttgaccagtacaacgagctgcacttgcccgctgtcatcctcaagaca
ttccttcgggagcttcctgaacccttgctaacctttgacctgtacccccatgttgtgggc
ttcctcaatattgatgaaagccagagagtggaagtgacacagcaggttctccaaactctg
ccagaggagaactaccaggtgcttcatttcctgactgccttcctggtgcagatatctgcc
cactgtgaccagaacaagatgaccaacactaacttggctgtagtcttcggccctaacctg
ctctgggctaaagatgctgccatcaccctcaaggctatcaatcccatcaacaccttcact
aagttcctcctggatcatcaaggggaattgttccccagcacagatgcccagggggtctta
atta

Protein Sequence

>ARHGAP1
MDPLSELQDDLTLDDTSQALNQLKLASIDEKNWPSDEMPDFPKSDDSKSSSPEPVTHLKW
DDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHSKLLGYLKHTLDQYVESDY
TLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISF
KFGRKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLKSTQKSPATAPKPMPPRPPLPNQ
QFGVSLQHLQEKSPGQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG
LPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRVEVTQQVLQTL
PEENYQVLHFLTAFLVQISAHCDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFT
KFLLDHQGELFPSTDAQGVLI

  • Gold
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  • IntAct