Field Data
UniProt Accession: Q12979
Gene Name: ABR
Gene Synonim:
GAP/GEF: GAP, GEF
Description: Active breakpoint cluster region-related protein
Keywords: Alternative splicing;Complete proteome;GTPase activation;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 29
Ensembl Gene ID: ENSG00000278741
Ensembl Protein ID: ENSP00000486214
Our Specificity Rac1
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005829cytosol
GO:0016020membrane
GO:0005886plasma membrane

Molecular Function


GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process


GO ID Description
GO:0050766positive regulation of phagocytosis
GO:0030336negative regulation of cell migration
GO:0043314negative regulation of neutrophil degranulation
GO:0042472inner ear morphogenesis
GO:0007420brain development
GO:0050885neuromuscular process controlling balance
GO:0051056regulation of small GTPase mediated signal transduction
GO:0060313negative regulation of blood vessel remodeling
GO:0035023regulation of Rho protein signal transduction
GO:0050728negative regulation of inflammatory response
GO:0030036actin cytoskeleton organization
GO:0043114regulation of vascular permeability
GO:0043065positive regulation of apoptotic process
GO:0007165signal transduction
GO:0002692negative regulation of cellular extravasation
GO:0032496response to lipopolysaccharide
GO:0007264small GTPase mediated signal transduction
GO:0035556intracellular signal transduction
GO:0043547positive regulation of GTPase activity

Reactome


Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG



Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ABR
atggcagccgggggccgccgccggcgcccactgcgctaccagtccctggcagccctggtg
gaagactctcagtggcctttcttgttccttgtctcagacttcagctacggtgcggaggac
tacgacgcagaggggcatgaggagcagaaggggccccccgagggctcggagaccatgccg
tacatcgacgagtcacccaccatgtcgccccagctcagcgcccgcagccaaggtggtggg
gacagcgtctcgcccaccccacctgagggattggcacctggggtggaggcagggaagggt
ctggagatgaggaagctagtcctctctgggtttctggccagtgaagagatctacattaac
cagctggaagctctgttactgcccatgaaacccctgaaggccacagccaccacctcccag
cctgtgctcaccatccaacagattgagaccatcttctacaagatccaggacatctacgag
atccacaaggagttctacgacaacctctgccccaaggtgcagcagtgggacagccaggtc
accatgggccatcttttccagaaactggccagccagcttggcgtgtacaaagcatttgtg
gataactataaagtcgctctggagacagccgagaagtgcagccagtccaacaaccagttc
cagaagatctctgaggaactcaaagtgaaagggcccaaggactctaaggacagccataca
tcagtcaccatggaagctctgctgtacaagccaattgaccgagtcacccggagcaccctg
gtccttcacgatctgttgaagcacacacccgtggaccacccggactacccgctgcttcag
gatgctctccgcatctcccagaatttcctgtctagcattaacgaggacattgatcctcgc
cggactgcagtcacaacccccaagggagagactcggcagctggtgaaggacggcttcctg
gtggaaatgtctgagagctcccggaagctgcggcatgtctttctcttcacagatgttctg
ctgtgtgccaagctaaagaagacctcagcaggaaagcatcagcagtatgactgtaagtgg
tacatccctctggctgacttagtgttcccatcccctgaggagtcagaggccagtccccag
gtgcaccccttcccagaccacgagctcgaggacatgaaaacgaagatctctgccctcaag
agtgagatccagaaggagaaagccaacaaaggacagagccgagccattgagcgcctcaaa
aagaagatgtttgagaatgagttcttactgctgctcaattccccaacgatccctttccgg
atacacaatcggaatggaaagagttacctgtttcttctgtcttctgactatgagaggtcg
gagtggagagaagcgattcagaagctacagaagaaggatctccaggcctttgtcctgagc
tctgtggagctccaggtgctcacgggatcctgtttcaagcttaggactgtgcacaacatt
cctgtcaccagcaataaagatgatgatgagtctccaggactgtacggcttccttcatgtc
atcgtccactctgccaagggctttaaacagtcagccaatctttactgtactctggaggtg
gattcctttggctattttgtcagcaaagccaagaccagggtgtttcgggacacgacagag
cccaagtgggatgaggagtttgagattgagctggagggttcacagtccctgaggatcctg
tgttatgagaagtgctacgacaagaccaaggtcaacaaagacaacaatgagattgtggac
aagatcatgggcaaggggcagatccagctggatccacagacagtagaaagcaagaactgg
catacggacgtgattgaaatgaatgggatcaaagtggaattctccatgaaatttaccagc
cgtgacatgagcctgaagaggaccccatccaaaaagcagacaggcgtctttggagtgaag
atcagcgtggtgaccaagcgggagcgctccaaggtgccctacatcgtccggcaatgcata
gaagaggtggagaagaggggcattgaggaggttggcatctacaggatatcaggggtggcc
acggacatccaggccctgaaggctgtctttgatgccaataacaaggacatcctactgatg
ctgagcgacatggacatcaacgccatcgctgggaccctcaagctatactttcgggagctg
cctgagcccctccttacagatagactttatccagccttcatggagggcattgccctgtca
gaccctgctgccaaggagaactgcatgatgcacctactccgctccctgcctgaccccaac
ctcatcaccttccttttcctgctggaacacttgaaaagggttgctgagaaggagcccatc
aacaagatgtcacttcacaaccttgccacggtgtttggccccacgttactgagaccatca
gaagtggagagcaaagcacatctcacatcagctgcagacatctggtcccatgatgtcatg
gcccaggtccaggtcctcctctactacctgcagcatccccccatttccttcgcagaactg
aagcggaacacactgtacttctccacagacgtgt

Protein Sequence

>ABR
MAAGGRRRRPLRYQSLAALVEDSQWPFLFLVSDFSYGAEDYDAEGHEEQKGPPEGSETMP
YIDESPTMSPQLSARSQGGGDSVSPTPPEGLAPGVEAGKGLEMRKLVLSGFLASEEIYIN
QLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQV
TMGHLFQKLASQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHT
SVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDALRISQNFLSSINEDIDPR
RTAVTTPKGETRQLVKDGFLVEMSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKW
YIPLADLVFPSPEESEASPQVHPFPDHELEDMKTKISALKSEIQKEKANKGQSRAIERLK
KKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEWREAIQKLQKKDLQAFVLS
SVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEV
DSFGYFVSKAKTRVFRDTTEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVD
KIMGKGQIQLDPQTVESKNWHTDVIEMNGIKVEFSMKFTSRDMSLKRTPSKKQTGVFGVK
ISVVTKRERSKVPYIVRQCIEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLM
LSDMDINAIAGTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPN
LITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPSEVESKAHLTSAADIWSHDVM
AQVQVLLYYLQHPPISFAELKRNTLYFSTDV

  • Gold
  • Silver
  • Bronze
  • IntAct