---

Cellular Component

---

GO ID	Description
GO:0005737	cytoplasm
GO:0044304	main axon
GO:0044291	cell-cell contact zone
GO:0043197	dendritic spine
GO:0032587	ruffle membrane
GO:0043025	neuronal cell body
GO:0005634	nucleus
GO:0016020	membrane
GO:0044295	axonal growth cone
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0036477	somatodendritic compartment
GO:0005911	cell-cell junction
GO:0005886	plasma membrane
GO:0005874	microtubule
GO:0005829	cytosol
GO:0030054	cell junction
GO:0045202	synapse

---

Molecular Function

---

GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0005057	signal transducer activity, downstream of receptor
GO:0008017	microtubule binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0008289	lipid binding
GO:0017016	Ras GTPase binding
GO:0019900	kinase binding
GO:0048365	Rac GTPase binding
GO:0030971	receptor tyrosine kinase binding
GO:0005515	protein binding

---

Biological Process

---

GO ID	Description
GO:1904268	positive regulation of Schwann cell chemotaxis
GO:0098989	NMDA selective glutamate receptor signaling pathway
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0043507	positive regulation of JUN kinase activity
GO:0035556	intracellular signal transduction
GO:0032092	positive regulation of protein binding
GO:0016601	Rac protein signal transduction
GO:2000050	regulation of non-canonical Wnt signaling pathway
GO:0003300	cardiac muscle hypertrophy
GO:0043065	positive regulation of apoptotic process
GO:0016477	cell migration
GO:0008284	positive regulation of cell proliferation
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0030335	positive regulation of cell migration
GO:1990138	neuron projection extension
GO:0006915	apoptotic process
GO:1904338	regulation of dopaminergic neuron differentiation
GO:0060071	Wnt signaling pathway, planar cell polarity pathway
GO:0010976	positive regulation of neuron projection development
GO:0042220	response to cocaine
GO:0048013	ephrin receptor signaling pathway
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0050772	positive regulation of axonogenesis
GO:0010717	regulation of epithelial to mesenchymal transition
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0090630	activation of GTPase activity
GO:1905274	regulation of modification of postsynaptic actin cytoskeleton
GO:0070372	regulation of ERK1 and ERK2 cascade
GO:0072657	protein localization to membrane

---

Reactome

---

Reactome ID	Description
R-HSA-3928665	EPH-ephrin mediated repulsion of cells
R-HSA-3928662	EPHB-mediated forward signaling
R-HSA-194840	Rho GTPase cycle
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-193648	NRAGE signals death through JNK

---

KEGG

---

Kegg ID	Description
hsa05205	Proteoglycans in cancer
hsa04024	cAMP signaling pathway
hsa04530	Tight junction
hsa04015	Rap1 signaling pathway
hsa04014	Ras signaling pathway
hsa04062	Chemokine signaling pathway
hsa04810	Regulation of actin cytoskeleton

---

Field	Data
Localization in this study:	plasma_membrane
Localization in the literature:	plasma membrane focal adhesions plasma membrane (junctions)