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Cellular Component

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GO ID	Description
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0001726	ruffle
GO:0042995	cell projection
GO:0000322	storage vacuole
GO:0030027	lamellipodium
GO:0005829	cytosol
GO:0005938	cell cortex
GO:0043005	neuron projection
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0043025	neuronal cell body
GO:0030054	cell junction

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Molecular Function

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GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0019901	protein kinase binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

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Biological Process

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GO ID	Description
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0007030	Golgi organization
GO:2000394	positive regulation of lamellipodium morphogenesis
GO:0043547	positive regulation of GTPase activity
GO:0007399	nervous system development
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:0030032	lamellipodium assembly
GO:0048041	focal adhesion assembly
GO:0032092	positive regulation of protein binding
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0002244	hematopoietic progenitor cell differentiation
GO:0007165	signal transduction
GO:0060124	positive regulation of growth hormone secretion
GO:0035023	regulation of Rho protein signal transduction
GO:0010763	positive regulation of fibroblast migration
GO:0035556	intracellular signal transduction
GO:1904424	regulation of GTP binding
GO:0048013	ephrin receptor signaling pathway

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Reactome

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Reactome ID	Description
R-HSA-3928664	Ephrin signaling
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-194840	Rho GTPase cycle
R-HSA-182971	EGFR downregulation
R-HSA-193648	NRAGE signals death through JNK

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KEGG

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Kegg ID	Description
hsa04810	Regulation of actin cytoskeleton

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Field	Data
Localization in this study:	focal_adhesions
Localization in the literature:	vesicles focal adhesions