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Cellular Component

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GO ID	Description
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0032045	guanyl-nucleotide exchange factor complex

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Molecular Function

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GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0017124	SH3 domain binding
GO:0005515	protein binding

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Biological Process

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GO ID	Description
GO:0010634	positive regulation of epithelial cell migration
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007596	blood coagulation
GO:0007010	cytoskeleton organization
GO:0043547	positive regulation of GTPase activity
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:0007229	integrin-mediated signaling pathway
GO:0006915	apoptotic process
GO:0006911	phagocytosis, engulfment
GO:0007165	signal transduction
GO:0016477	cell migration
GO:0006909	phagocytosis
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction

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Reactome

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Reactome ID	Description
R-HSA-4420097	VEGFA-VEGFR2 Pathway
R-HSA-418885	DCC mediated attractive signaling
R-HSA-8849471	PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-983231	Factors involved in megakaryocyte development and platelet production
R-HSA-2029482	Regulation of actin dynamics for phagocytic cup formation

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KEGG

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Kegg ID	Description
hsa05131	Shigellosis
hsa04510	Focal adhesion
hsa05100	Bacterial invasion of epithelial cells
hsa04810	Regulation of actin cytoskeleton

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Field	Data
Localization in this study:	actin, focal_adhesions, plasma_membrane
Localization in the literature:	nucleus cytosolic focal adhesions