Field Data
UniProt Accession: Q15052
Gene Name: ARHGEF6
Gene Synonim: COOL2, KIAA0006, PIXA
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 6 (Alpha-Pix) (COOL-2) (PAK-interacting exchange factor alpha) (Rac/Cdc42 guanine nucleotide exchange factor 6)
Keywords: 3D-structure;Alternative splicing;Cell projection;Complete proteome;Guanine-nucleotide releasing factor;Mental retardation;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 9459
Ensembl Gene ID: ENSG00000129675
Ensembl Protein ID: ENSP00000359656
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0030027lamellipodium
GO:0005829cytosol
GO:0042995cell projection
GO:0005622intracellular

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007254JNK cascade
GO:0043547positive regulation of GTPase activity
GO:0030032lamellipodium assembly
GO:0006915apoptotic process
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-446388Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Kegg ID Description
hsa05212Pancreatic cancer
hsa04810Regulation of actin cytoskeleton
Field Data
Localization in this study: focal_adhesions
Localization in the literature: focal adhesions cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF6
atgcctggctctgtggaaaagttttgtctggatccccaaactgaagctgactgcatcaac
aacatcaatgacttcctgaaaggatgtgcaaccctccaagtggaaatatttgatcctgat
gacctttattcaggggtcaatttctccaaggtactgagtactcttttagctgtcaacaaa
gcaacagaagatcagctatcagaaagaccatgtggacgttcctcttctcttagtgctgct
aatacttctcagacaaacccacagggagcagtttctagcacagtttcagggctgcaaagg
cagtcaaagacagtggagatgacggaaaatggaagtcatcagttgatagtaaaagcaaga
ttcaactttaagcagactaatgaggatgaactgtcagtttgtaagggggacatcatttac
gtcacacgagttgaagaaggaggctggtgggaaggcacattaaatgggagaacaggctgg
ttccccagtaattatgtccgtgaaattaaatccagtgagagacctctctccccaaaagcc
gtcaaaggatttgaaactgctccacttaccaagaattattatactgtggtgttacagaac
atcctggacactgaaaaagaatatgctaaagaacttcagtctcttcttgttacttactta
agacccctgcagtccaataacaatctgagtactgtggaggttacatctttactgggaaac
ttcgaggaagtatgcacatttcaacagacactctgccaagccttggaagaatgttcaaag
tttccagaaaaccagcacaaagtaggaggttgtctactgagtctcatgcctcattttaaa
tctatgtatctggcttactgtgcaaaccatccttcagctgtaaatgtgctcactcagcac
agtgatgagttggaacaattcatggaaaatcaaggtgcatcgagcccaggtatcctcatt
ttaacaacaaacctcagcaaaccattcatgcgactggagaaatatgttactctcttgcaa
gagttagaacggcatatggaggatactcatccagatcatcaggatattctgaaagcaatc
gtagcattcaaaactctcatggggcaatgtcaagatctgaggaagagaaaacagctggag
ttacagatactgtccgaacctattcaggcatgggaaggagaagatattaaaaacttggga
aatgtgatttttatgtcacaagtaatggtgcagtatggagcatgtgaggaaaaagaggag
cggtaccttatgttattttcaaatgtcctgataatgttatctgcaagtcctcggatgagt
ggctttatctatcagggaaaaataccaatagcaggaacggtggtgactagattagatgaa
attgaagggaatgactgcacatttgaaatcactggtaacacagtggagagaattgtggtc
cattgtaacaacaaccaggacttccaggaatggttggagcagctgaacagactgatcaga
ggacctgcctcttgcagttcattatccaaaacctcatcgtcatcatgtagtgctcattct
tcttttagctctaccggacagccccgaggacccttggagcctcctcaaattataaaaccg
tggagtttaagttgtctacgacctgcacctccacttagaccatcagcagcactaggttat
aaagagaggatgtcttatatcttaaaggagtctagtaaaagccctaaaacgatgaagaaa
tttcttcataaaaggaagactgagagaaaaccatcggaggaggaatatgtgattaggaaa
agtacagctgctctggaagaggatgctcaaatccttaaagtgatcgaagcctactgcacc
agcgcaaattttcaacaaggccatggctcaagtactcgaaaagattccattccacaagtc
ctactccctgaggaagagaaactcatcattgaagaaaccagaagcaacggccagaccatc
atggaagaaaagagccttgttgatactgtttacgccttgaaggacgaggtcagagaactg
aagcaggaaaataaaagaatgaagcaatgcctggaagaagaactgaaatcaagaagggac
ctagaaaagctggtgcggaggcttttgaagcaaacagatgagtgtattcgaggcgagtcc
agtagcaagacctcaattcttccattaatta

Protein Sequence

>ARHGEF6
MPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNK
ATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKAR
FNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKA
VKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGN
FEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQH
SDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAI
VAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEE
RYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVV
HCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKP
WSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRK
STAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTI
MEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGES
SSKTSILPLI

  • Gold
  • Silver
  • Bronze
  • IntAct