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Cellular Component

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GO ID	Description
GO:0030027	lamellipodium
GO:0005829	cytosol
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0012505	endomembrane system
GO:0043005	neuron projection
GO:0005886	plasma membrane
GO:0045202	synapse
GO:0042995	cell projection
GO:0030054	cell junction
GO:0005905	clathrin-coated pit

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Molecular Function

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GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0070064	proline-rich region binding
GO:0019209	kinase activator activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0032947	protein complex scaffold activity

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Biological Process

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GO ID	Description
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0042327	positive regulation of phosphorylation
GO:0006897	endocytosis
GO:0043547	positive regulation of GTPase activity
GO:0043065	positive regulation of apoptotic process
GO:0061024	membrane organization
GO:0043524	negative regulation of neuron apoptotic process
GO:0016032	viral process
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0051897	positive regulation of protein kinase B signaling
GO:0048013	ephrin receptor signaling pathway
GO:0048488	synaptic vesicle endocytosis

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Reactome

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Reactome ID	Description
R-HSA-8856828	Clathrin-mediated endocytosis
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis
R-HSA-3928662	EPHB-mediated forward signaling
R-HSA-194840	Rho GTPase cycle
R-HSA-193648	NRAGE signals death through JNK

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KEGG

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Field	Data
Localization in this study:	focal_adhesions, vesicles
Localization in the literature:	vesicles