Field Data
UniProt Accession: Q17R89
Gene Name: ARHGAP44
Gene Synonim: KIAA0672, RICH2
GAP/GEF: GAP
Description: Rho GTPase-activating protein 44 (NPC-A-10) (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2)
Keywords: Alternative splicing;Cell junction;Cell projection;Complete proteome;Endosome;Exocytosis;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;Synapse
Entrez ID: 9912
Ensembl Gene ID: ENSG00000006740
Ensembl Protein ID: ENSP00000368994
Our Specificity Rac1
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0043197dendritic spine
GO:0031256leading edge membrane
GO:0005829cytosol
GO:0045202synapse
GO:0042995cell projection
GO:0005768endosome
GO:0055037recycling endosome
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0048365Rac GTPase binding
GO:0005543phospholipid binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0006887exocytosis
GO:0061001regulation of dendritic spine morphogenesis
GO:0098887neurotransmitter receptor transport, endosome to postsynaptic membrane
GO:0098886modification of dendritic spine
GO:0035021negative regulation of Rac protein signal transduction
GO:0032956regulation of actin cytoskeleton organization
GO:0043087regulation of GTPase activity
GO:0007165signal transduction

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: actin

Confocal Images

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Cytochalasin D Screen Positive

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP44
atgaagaagcagttcaatcgcatgcgccagctggccaaccagacggtgggcagggctgaa
aagacagaagttttgagtgaagaccttcttcaggtggagaagcgtctggagctggtgaaa
caggtgtcccacagcacgcacaagaagctcaccgcatgtctgcagggccagcaaggggca
gaggctgacaagcgctccaaaaagttgcctttgacaacactggctcagtgtctgatggag
gggtcagctatcctgggagatgacacacttcttgggaagatgctgaaactctgtggagag
acggaggacaagctggctcaggagctgatacattttgagttgcaagtagagagagacgtg
attgagcccctgtttttgctggcggaggtggaaatcccaaatattcaaaagcagaggaaa
cacttagccaagttggtgctggacatggattcctcacgaaccaggtggcagcagacttcc
aagtcttcaggtttgtccagcagcttacagcctgcgggtgccaaggctgatgccctcagg
gaagaaatggaagaggctgccaacagagtggagatttgcagggaccagctctcagctgat
atgtacagttttgtggccaaagaaattgactatgcaaactactttcaaacgctaatagaa
gtgcaagctgaataccacaggaagtccctgacactattgcaggctgtattgcctcagatc
aaagcacaacaggaggcctgggtagagaagccttccttcgggaagccgctggaggagcac
ctcaccatcagcggccgggagatcgccttccccatcgaggcgtgtgtgaccatgctgctt
gagtgtgggatgcaggaggagggactcttccgagtagccccctctgcctccaaactgaag
aagctgaaagcggccctggactgctgcgtggtggatgtgcaggagtactcggcagacccc
cacgcaattgcaggagctttgaaatcttacctccgagagttgccagaacctcttatgacc
tttgaactctatgatgagtggatccaggcttccaatgtccaggagcaagacaagaagctt
caggctctatggaatgcttgtgaaaagttgcccaaggccaatcacaacaacatccgatac
ttgataaaatttttatccaagctgtcagaatatcaagatgtaaacaagatgactcccagt
aatatggcaattgttttaggacccaacctcctatggccacaagcagaagggaacattaca
gagatgatgaccacagtgtcgctgcaaattgttgggatcattgaacctatcatccagcat
gcagactggttcttccctggggagatagagttcaacattactggcaattatgggagtcca
gtacacgtgaaccataatgccaactacagctcaatgccctccccagacatggaccctgct
gaccggcgccagcccgagcaggcccgccggcccctcagcgtcgccacggataatatgatg
ctggagttttacaaaaaggatggccttaggaaaatccaaagcatgggtgtgagggtcatg
gacacaaactgggtggctcgaagaggctcctcggccggtcggaaagtgtcctgcgccccg
ccctccatgcagcctcccgccccgcccgccgagctggctgcgcccctgccttcgccgctg
ccggagcagcccctggacagccccgcggcccccgcgctctctccatccggcctgggcctc
cagcctgggcccgagcgcaccagcacaacaaaaagcaaggaactttctccaggctctgca
cagaaaggaagtccaggctccagccagggcacagcctgtgcagggactcaaccaggggct
caacctggagctcagccgggcgccagccccagccccagccagccgcctgcagaccagagt
cctcacaccctccggaaagtttcaaagaagctggcaccgattccacccaaggtccccttt
ggccagccgggggctatggcagaccagtccgctggccagctgtccccagtcagcctgtcc
cccaccccgcccagcaccccgtcaccctatggactgagctaccctcaggggtactccttg
gcctcgggccagctctccccagctgcagctcctcccctggcctctccttctgtctttaca
agcactttgagcaaatcgcggcccactcctaagccgcgacagagacctactctgccgcct
cctcagcctcccacagtaaacctctcggcctctagtccacagtccacggaggcccccatg
ctagatggcatgtcccctggggaaagcatgtctacagatcttgtccactttgatattccc
tcgatccacatagagctcgggtcgacgctccgcctgagtcccctggagcacatgcggcga
cactcagtaactgacaagagggactcggaggaggagtctgagagcaccgccctcttaatt
a

Protein Sequence

>ARHGAP44
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGA
EADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDV
IEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQI
KAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLK
KLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKL
QALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNIT
EMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPA
DRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAP
PSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSA
QKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPF
GQPGAMADQSAGQLSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFT
STLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIP
SIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTALLI

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  • IntAct