Field Data
UniProt Accession: Q2M1Z3
Gene Name: ARHGAP31
Gene Synonim: CDGAP, KIAA1204
GAP/GEF: GAP
Description: Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)
Keywords: Cell junction;Cell projection;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 57514
Ensembl Gene ID: ENSG00000031081
Ensembl Protein ID: ENSP00000264245
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0030027lamellipodium
GO:0042995cell projection
GO:0005829cytosol
GO:0005925focal adhesion
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0017124SH3 domain binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007264small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions, nucleus
Localization in the literature: focal adhesions

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP31
atgaagaacaagggtgctaagcagaagctgaaacgaaagggagccgccagcgcgtttggc
tgtgacctgacggagtatctggaaagctcgggacaggatgttccatacgttttgaagagc
tgtgcagaatttatagagactcacggcatcgtggatggaatctatcggctttcaggagtc
acctcaaacatacaacggctaaggcaagagtttggctcagatcaatgtccagatctgaca
agggaagtgtacctccaggacatccactgtgtgggctcgctttgcaagctctactttagg
gagctgcccaaccccctcctgacttatgagctctatgagaaattcacggaggcagtgtcg
cattgccctgaagaaggccaactggcccgaatccaaaatgttatccaggagcttcctcca
tcccactataggaccttggaatacctgattcgacacctggcccatatcgcctccttcagc
agcaagaccaacatgcacgcccggaacctggccctggtgtgggcgccaaacctcctcagg
tctaaagaaattgaagccactggttgcaatggagatgcagccttccttgcagtccgggtc
cagcaggtggtgattgagttcatattgaatcatgtagatcaaatctttaacaacggtgca
cctgggtctctggagaatgatgaaaaccggcccatcatgaagagcctgaccttgccagcc
ctctccctgcccatgaagctggtgagccttgaggaagctcaagcccgcagcctggccact
aaccatcctgctcgcaaggaaaggagggagaacagcctgcctgagattgtccctcccatg
ggcaccctcttccacactgtccttgagttaccagacaacaagcgaaagctctccagtaaa
tcaaagaagtggaaatcaatatttaacctgggacgttctggatcagactccaaatcaaaa
ctgagtagaaatgggagtgtatttgtgagaggacagaggctctcggtggaaaaggctact
atccgaccagctaaaagcatggactcactatgttcagtgcctgtggaaggaaaagaaacc
aagggaaatttcaatcgaacagttaccaccggtggatttttcattccagcaacaaagatg
cactccaccggcaccggcagctcatgtgacctcaccaagcaggagggcgaatggggccag
gaggggatgcctcccggggctgagggtggctttgatgtgagcagtgatcgcagccatctc
cagggcgctcaggcccggcccccaccggaacagctgaaggttttccggcctgttgaggat
ccggagagcgagcaaacagccccaaagatgttgggtatgttctacacttcgaacgacagc
cctagcaaatccgtcttcaccagcagcctcttccagatggagccctcgccgcgtaaccag
cgcaaggcgctgaacatctccgagccctttgcggtatctgtgccgctccgcgtgtccgca
gtcatcagcaccaacagcacgccgtgcagaacacccccgaaggagctgcagtctctttcc
agcctggaagagttttcttttcatggatcagagagcggaggctggccagaagaagagaaa
ccgctgggagctgagacttctgcagcttctgtacctaagaaggcaggtcttgaggatgcc
aaggcagtacctgaagcaccagggacagtggaatgcagcaaaggcctgtcccaggagcca
ggcgcccacctggaggagaagaaaaccccagaaagctccttgagctctcaacatttaaat
gaattagagaagaggccaaatccggagaaggtggtggaggagggacgagaggctggtgag
atggagtccagcaccctgcaggagagccccagggccagagccgaagctgtgcttctccat
gagatggatgaagatgatctggccaatgccctgatctggcctgagattcaacaggagctg
aaaatcattgaatctgaggaggagctctcatcgttgccacctcctgctctgaagaccagc
ccaattcagcctattctcgagtcgagtctggggccctttattccctcagagcctcctggg
agcttgccttgtggctccttccctgctccagtctccacccctctggaggtgtggactagg
gatccagccaatcagagcacacagggggcttccacagcagccagcagagagaagccggaa
cctgagcagggcctgcacccagacctcgccagcctggctcctctggaaatagttcctttt
gagaaggcatctccacaagcaacagtggaagtaggaggcccaggcaatctgtctcctcca
ctcccacctgctcctccccctccaactcctctggaggagtcaactccagtcctgctttca
aagggcagcccggaaagagaagactcatccaggaaattgaggacagatctctacatagac
cagctgaagtcccaagacagccctgagatctctagcctctgtcagggagaggaggcaacc
ccaagacacagtgacaagcaaaattcaaagaatgctgcttctgaggggaaaggctgtggt
tttccaagcccaaccagggaggttgagatcgtctcacaagaagaggaggatgtaacccat
tcagtacaggagccttcagactgtgacgaagatgacactgtgacagacattgcccagcat
ggcctggagatggtggagccctgggaggaaccccagtgggtgacgagtccccttcactct
cccaccctgaaagacgcgcacaaggcccaggtacagggccttcagggtcaccagttggag
aagaggctttcccacaggcccagccttcgccagagccattctctagatagcaaacccacg
gttaaaagccagtggactctcgaggttccctcctccagcagctgtgctaatcttgaaaca
gagaggaattctgaccctcttcagccccaggcacccaggagagagattactggatgggat
gagaaagccctgaggtccttcagagagttctctggcctgaaaggggcagaggctcctccc
aaccagaagggaccaagtggtgtgcaacccaacccagcagaaaccagccccatcagccta
gcagagggaaaggagctagggacacacctggggcacagcagtccacagattaggcaaggt
ggtgttcctgggccagagagcagcaaggagagttcacccagcgtgcaggacagcacttcg
cctggagagcaccccgcaaagttacagctaaagagcacagagtgtgggcccccaaaaggg
aaaaacaggccttcttccctcaacttggaccctgccattcccattgctgacctcttctgg
tttgagaatgtggcctcatttagttcacctggaatgcaggtctctgagccaggagaccca
aaggtcacatggatgacctcatcttactgtaaagcagacccctggagggtttactcccag
gacccccaggacctggacattgttgctcatgcactgacaggccgccgtaactcagctcct
gtgagtgtgtcagctgtgagaacctccttcatggtcaaaatgtgccaggccagggcggtc
ccagtcatccctcccaagattcagtacacccagatcccacagcccctgccctctcagagc
tcaggggagaatggggttcagcctctggagaggagccaggagggacccagctcaaccagt
gggaccactcagaaacctgccaaagatgattctccctcctccctggaaagctcaaaggaa
gaaaaaccaaagcaagatcccggagccattaagtcctcaccagtggatgccactgcaccc
tgcatgtgcgagggacctaccctttctccagaaccaggctcgtctaacctgctctccacc
caggatgcagtagtgcaatgcagaaagcgcatgtcagagacagagccatctggggacaac
cttctttcttcaaaactagagcgaccatctgggggttctaagcctttccacaggtcaagg
ccaggaagacctcagagcctaatcttattcagtcctcctttccccattatggaccacctg
cccccttcatccacagtgacagattccaaggtcctgctgtcccctatcagaagtcccacc
cagacagtttcccctggccttctttgtggagagttggcagaaaacacatgggtcacacca
gaaggggttacacttaggaataaaatgaccatccctaagaatggccagagactagagacc
tcaaccagctgtttttaccagcctcagcggagatcagtaattctggatggaagaagtggg
aggcaaatagaaggaagctt

Protein Sequence

>ARHGAP31
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGV
TSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVS
HCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLR
SKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNNGAPGSLENDENRPIMKSLTLPA
LSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPMGTLFHTVLELPDNKRKLSSK
SKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKET
KGNFNRTVTTGGFFIPATKMHSTGTGSSCDLTKQEGEWGQEGMPPGAEGGFDVSSDRSHL
QGAQARPPPEQLKVFRPVEDPESEQTAPKMLGMFYTSNDSPSKSVFTSSLFQMEPSPRNQ
RKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFHGSESGGWPEEEK
PLGAETSAASVPKKAGLEDAKAVPEAPGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLN
ELEKRPNPEKVVEEGREAGEMESSTLQESPRARAEAVLLHEMDEDDLANALIWPEIQQEL
KIIESEEELSSLPPPALKTSPIQPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTR
DPANQSTQGASTAASREKPEPEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPP
LPPAPPPPTPLEESTPVLLSKGSPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEAT
PRHSDKQNSKNAASEGKGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQH
GLEMVEPWEEPQWVTSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPT
VKSQWTLEVPSSSSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPP
NQKGPSGVQPNPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTS
PGEHPAKLQLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDP
KVTWMTSSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAV
PVIPPKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKE
EKPKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDN
LLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRSPT
QTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSG
RQIEGS

  • Gold
  • Silver
  • Bronze
  • IntAct