Field Data
UniProt Accession: Q3KR16
Gene Name: PLEKHG6
Gene Synonim:
GAP/GEF: GEF
Description: Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF)
Keywords: Alternative splicing;Cell projection;Complete proteome;Cytoplasm;Cytoskeleton;GTPase activation;Polymorphism;Reference proteome
Entrez ID: 55200
Ensembl Gene ID: ENSG00000008323
Ensembl Protein ID: ENSP00000393194
Our Specificity RhoA, Rac1
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0005819spindle
GO:0032154cleavage furrow
GO:0000922spindle pole
GO:0005902microvillus
GO:0005886plasma membrane
GO:0042995cell projection

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: actin
Localization in the literature: mitotic spindle, cleavage furrow actin

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>PLEKHG6
atgaaggcctttggtcctccacatgagggccccctccaaggactcgtggcctcccgcatt
gagacttatgggggccggcatcgagcctctgctcagagcactgctggcagactctatccc
cgaggataccctgtgctggatcccagtcgccgacgcctccagcagtatgtcccctttgcc
aggggttctggccaggcccgaggcctgtcacccatgagactgcgagatccagagcccgag
aagaggcacgggggccatgtgggggctggcctgcttcactcccccaaactcaaggaactc
accaaggcccatgagctggaggtgaggctgcacactttcagcatgtttgggatgccccgg
ctgccccctgaggaccggcggcactgggagataggagagggtggcgacagtggcctgacc
atcgagaagtcctggagggagctggtgcctgggcacaaggagatgagccaggagctctgc
caccaacaggaggccctgtgggagctcctgaccaccgagctgatctacgtgagaaagctc
aagatcatgactgatctgctagccgccggcctgctgaacctgcagcgagtgggactgctg
atggaagtgtcagctgagaccctgtttggaaatgtccccagcctgattcgaacccaccgg
agcttttgggatgaggtgctggggcccaccctggaggagactcgggcctcgggccagcct
ctggaccccattggtctgcaaagtggcttcctgacgtttggccagcggttccacccctat
gtccagtactgcctccgagtgaagcagaccatggcttacgcccgagaacagcaagaaact
aaccctctcttccatgccttcgtgcagtggtgtgagaagcacaagcgctctgggaggcag
atgctctgtgacttgcttatcaagccccaccagcgcatcaccaagtacccactgctgctc
catgctgtgctcaagaggagccccgaggcacgagcccaagaggccctgaatgccatgatt
gaagccgtggagtcattcctgcgacacatcaatgggcaggtccgccagggcgaagagcaa
gagagcttggcggctgcagcacaacgcatcgggccctacgaggtgctggagccacccagt
gatgaggtggagaagaacctgcgcccattctccaccctggacctgacgtcccccatgctg
ggggttgcatctgagcacaccagacagctgctgctggaggggcctgtgcgagtgaaggag
ggacgagaagggaagctggacgtgtacctgttcctcttctctgatgtgctccttgtgacc
aagccccagcgcaaggcggacaaagccaaggtcatccgaccccctctcatgctggagaag
ctcgtgtgccaacccctgcgagaccccaacagcttcctgctgatccacctcactgaattc
cagtgtgtctccagcgccctccttgtgcactgtcccagtcctacagaccgtgcccagtgg
ctggagaagacccagcaggcccaggccgccctacagaagctgaaggcagaggagtatgtt
caacagaagagggagctcctgaccctctatcgggaccaggacagggagtcccccagcacc
aggccctccacgccttccctggagggctctcagagcagcgcagaggggaggactcctgag
ttctcgaccattatcccccacctggtggtgacagaagacacagatgaagatgctcccctt
gtgccagatgatacctcagactctggctacggcactttgatcccaggcacccccacgggg
tcccgctccccactgagccgtctacgccaaagagcccttcggcgggaccctcgcctcacc
ttctccaccctggaactccgggacatccctctgcgtccccaccctcccgacccccaagct
cctcaacgccgaagcgcccccgaactgccggaaggaatcctaaaaggaggcagtcttccc
caggaagacccaccaacctggtctgaggaagaagatggggcctccgagcgagggaatgtg
gtggtggaaacactccacagggcccggcttcggggccagcttccctcctccccaacccat
gctgactctgccggggaaagcccctgggagtcctcaggggaggaggaagaagaggggcct
ctgttcctgaaagctggccacacatccctgcgcccaatgcgggctgaggacatgctcaga
gagatccgggaggagctggccagccaaaggattgagggggccgaggagccccgggacagc
aggccacggaagctgactcgggcccagctgcagaggatgcgggggccccacatcattcag
ctggacacccctctgtccgcatcagaggtat

Protein Sequence

>PLEKHG6
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFA
RGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPR
LPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKL
KIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQP
LDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQ
MLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQ
ESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKE
GREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEF
QCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPST
RPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTG
SRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLP
QEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGP
LFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQ
LDTPLSASEV

  • Gold
  • Silver
  • Bronze
  • IntAct