Field Data
UniProt Accession: Q52LW3
Gene Name: ARHGAP29
Gene Synonim: PARG1
GAP/GEF: GAP
Description: Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)
Keywords: Alternative splicing;Coiled coil;Complete proteome;Direct protein sequencing;GTPase activation;Metal-binding;Phosphoprotein;Polymorphism;Reference proteome;Zinc;Zinc-finger
Entrez ID: 9411
Ensembl Gene ID: ENSG00000137962
Ensembl Protein ID: ENSP00000359237
Our Specificity RhoA
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0046872metal ion binding
GO:0030165PDZ domain binding
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0007266Rho protein signal transduction
GO:0035556intracellular signal transduction
GO:0007165signal transduction
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: actin, plasma_membrane
Localization in the literature: plasma membrane cytosolic

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP29
atgattgctcacaaacagaaaaagacaaagaaaaaacgtgcttgggcatcaggtcaactc
tctactgatattacaacttctgaaatggggctcaagtccttaagttccaactctattttt
gatccggattacatcaaggagttggtgaatgatatcaggaagttctcccacatgttacta
tatttgaaagaagccatattttcagactgttttaaagaagttattcatatacgtctagag
gaactgctccgtgttttaaagtctataatgaataaacatcagaacctcaattctgttgat
cttcaaaatgctgcagaaatgctcactgcaaaagtgaaagctgtgaacttcacagaagtt
aatgaagaaaacaaaaacgatctcttccaggaagtgttttcttctattgaaactttggca
tttacctttggaaatatccttacaaacttccttatgggagatgtaggcaatgattcatta
ttgcgactgcctgtttctcgagaaactaagtcgtttgaaaatgtttctgtggaatcagtg
gactcatccagtgaaaaaggaaatttttcccctttagaactagacaacgtgctgttaaag
aacactgactctatcgagctggctttgtcatatgctaaaacttggtcaaaatatactaag
aacatagtttcatgggttgaaaaaaagcttaacttggaattggagtccactagaaatatg
gtcaagttggcagaggcaactagaactaacattggaattcaggagttcatgccactgcag
tctctgtttactaatgctcttcttaatgatatagaaagcagtcaccttttacaacaaaca
attgcagctctccaggctaacaaatttgtgcagcctctacttggaaggaaaaatgaaatg
gaaaaacaaaggaaagaaataaaagagctttggaaacaggagcaaaataaaatgcttgaa
gcagagaatgctctcaaaaaggcaaaattattatgcatgcaacgtcaagatgaatatgag
aaagcaaagtcttccatgtttcgtgcagaagaggagcatctgtcttcaagtggcggatta
gcaaaaaatctcaacaagcaactagaaaaaaagcgaaggttggaagaggaggctctccaa
aaagtagaagaagcaaatgaactttacaaagtttgtgtgacaaatgttgaagaaagaaga
aatgatctagaaaataccaaaagagaaattttagcacaactccggacacttgttttccag
tgtgatcttacccttaaagctgtaacagttaacctcttccacatgcagcatctgcaggct
gcttcccttgcagacagtttacagtctctctgtgatagtgccaaactctatgacccaggc
caagagtacagtgaatttgtcaaggccacaaattcaactgaagaagaaaaagttgatgga
aatgtaaataaacatttaaatagttcccaaccttcaggatttggacctgccaactcttta
gaggatgttgtacgccttcctgacagttctaataaaattgaagaggacagatgctctaac
agtgcagatataacaggtccttcctttataagatcatggacatttgggatgtttagtgat
tctgagagcactggagggagcagcgaatctagatctctggattcagaatctataagtcca
ggagactttcatcgaaaacttccacgaacaccatccagtggaactatgtcctctgcagat
gatctagatgaaagagagccaccttccccttcagaaactggacccaattcccttggaaca
tttaagaaaacattgatgtcaaaggcagctctcacacacaagtttcgcaaattgagatcc
cccacgaaatgtagggattgtgaaggcattgtagtgttccaaggtgttgaatgtgaagag
tgtctccttgtttgtcatcgaaagtgtttggaaaatttagtcattatttgtggtcatcag
aaacttccaggaaaaatacacttatttggagcagaattcacacaagttgcaaaaaaggaa
ccagatggtatcccttttatactcaaaatatgtgcctcagagattgaaaatagagctttg
tgtctacagggaatttatcgtgtgtgtggaaacaaaataaaaactgaaaaattgtgtcaa
gctttggaaaatggaatgcacttggtagatatttcagaatttagttcacatgatatctgt
gacgtcttgaaattataccttcggcagctcccagaaccatttattttatttcgattgtac
aaggaatttatagaccttgcaaaagagatccaacatgtaaatgaagaacaagagacaaaa
aagaatagtcttgaagacaaaaaatggccaaatatgtgtatagaaataaaccgaattctt
ctaaaaagcaaagaccttctaagacaattgccagcatcaaattttaacagtcttcatttc
cttatagtacatctaaagcgggtagtagatcatgcagaagaaaacaagatgaactccaaa
aacttgggggtgatatttggaccaagtctcattaggccaaggcccacaactgctcctatc
accatctcctcccttgcagagtattcaaatcaagcacgcttggtagagtttctcattact
tactcacagaagatcttcgatgggtccctacaaccacaagatgttatgtgtagcataggt
gttgttgatcaaggctgttttccaaagcctctgttatcaccagaagaaagagacattgaa
cgttccatgaagtcactatttttttcttcaaaggaagatatccatacttcagagagtgaa
agcaaaatttttgaacgagctacatcatttgaggaatcagaacgcaagcaaaatgcgtta
ggaaaatgtgatgcatgtctcagtgacaaagcacagttgcttctagaccaagaggctgaa
tcagcatcccaaaagatagaagatggtaaaacccctaagccactttctctgaaatctgat
aggtcaacaaacaatgtggagaggcatactccaaggaccaagattagacctgtaagtttg
cctgtagatagactacttcttgcaagtcctcctaatgagagaaatggcagaaatatggga
aatgtaaatttagacaagttttgcaagaatcctgcctttgaaggagttaatagaaaagac
gctgctactactgtttgttccaaatttaatggctttgaccagcaaactctacagaaaatt
caggacaaacagtatgaacaaaacagcctaactgccaagactacaatgatcatgcccagt
gcactccaggaaaaaggagtgacaacaagcctccagattagtggggaccattctatcaat
gccactcaacccagtaagccatatgcagagccagtcaggtcagtgagagaggcatctgag
agacggtcttcagattcctaccctctcgctcctgtcagagcacccagaacactgcagcct
caacattggacaacattttataaaccacatgctcccatcatcagtatcagggggaatgag
gagaagccagcttcaccctcagcagcagtgcctcctggcacagatcacgatccccacggt
ctcgtggtgaagtcaatgccagacccagacaaagcatcagcttgtcctgggcaagcaact
ggtcaacctaaagaagactctgaggagcttggcttgcctgatgtgaatccaatgtgtcag
agaccaaggctaaaacgaatgcaacagtttgaagacctcgaagatgaaattccacaattt
gtgt

Protein Sequence

>ARHGAP29
MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLL
YLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEV
NEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESV
DSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNM
VKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEM
EKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGL
AKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQ
CDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDG
NVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSD
SESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGT
FKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQ
KLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQ
ALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETK
KNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSK
NLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIG
VVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNAL
GKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSL
PVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKI
QDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASE
RRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHG
LVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEDEIPQF
V

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  • IntAct