Field Data
UniProt Accession: Q58EX7
Gene Name: PLEKHG4
Gene Synonim: PRTPHN1
GAP/GEF: GEF
Description: Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)
Keywords: Alternative splicing;Complete proteome;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 25894
Ensembl Gene ID: ENSG00000196155
Ensembl Protein ID: ENSP00000457086
Our Specificity Cdc42
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0090630activation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Positive

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>PLEKHG4
atggaaaggcccctggagaatggggatgagtccccagactctcagggccatgccaccgac
tggagatttgctgtgtgcagtttcagggatgcctgggaagaggaggaacctgcttcccag
atgcacgttaaggacccaggtcctccaagaccaccagccggggccacccaggatgaggag
ctacagggcagccccttgtccaggaaattccagttacccccagctgcagatgagtcgggg
gatgcccagaggggcacagtagaaagctcctcagtcctgtcagaagggccaggcccctct
ggagtggagagtctcctatgccccatgtcctcccacctcagcttggcacagggtgagagt
gacaccccaggggtagggttggtaggggacccaggtccaagcagggcgatgccatctggc
ttgagccctggggcattggacagcgaccctgtgggccttggagaccctttatcagaaata
tcaaagctgctggaggcagcccccagtggatccggcctccctaagcctgctgactgcctc
ctggcccaagacctctgttgggagctgctggccagtggtatggccaccttgccagggact
cgggatgtccaaggccgggcagtgctgcttctgtgtgcccacagcccagcctggcttcag
tctgagtgcagcagccaggaactcatccgcctcctgctgtacctgcgaagcatccccagg
cccgaagtacaggcactgggactgacagtgctagttgatgcccgaatttgtgctccaagt
tcttccctcttctctgggctcagccaactacaagaagcagccccaggggccgtgtaccag
gtgctgctagtgggaagcacgctgctgaaggaagtgccttccgggctgcagctggagcag
ttgccttctcagagcctgctgacccacatcccaacggcggggctgcccacttcgctagga
ggaggcctgccttactgccaccaggcctggctggatttccgaaggcggctggaagctcta
ctacagaactgccaggcagcttgtgccctgctccagggggccatcgaaagtgtgaaggct
gtgccccagcccatggagcctggggaggtcggtcagctgctacagcagacagaggtcctg
atgcagcaggtgctagactcgccatggctggcatggctacaatgccaggggggccgggag
ctgacatggctgaagcaagaggtcccagaggtgaccctgagcccagactacaggacggca
atggacaaggctgacgagctatatgaccgggtggatggattgctgcaccaactgaccctg
cagagcaaccagcgaatacaggccctagagttggtccaaacactggaggcccgggaaagc
ggactgcaccagattgaagtgtggctgcagcaggtgggctggccagcactggaggaggct
ggggagccctcgctggacatgctgctccaggcccaaggctcttttcaggagctgtaccag
gttgcccaggagcaggtcaggcaaggggagaagtttctgcagccgctgactggctgggag
gcggctgaactggacccccctggggcacgctttctggccctgcgagcccagctgactgaa
ttctctagggctttggcccagcggtgccagcggctggcggatgctgagaggctgtttcag
ctcttcagggaggccttgacgtgggctgaggaggggcagcgagtgttggcagagctggag
caggaacgcccgggggttgtgttgcagcagctgcagctgcactggaccaggcaccctgac
ttgcctcctgcccacttccgaaagatgtgggctctggccacggggctgggctcagaggcc
atccgccaggagtgccgctgggcctgggcgcggtgccaggacacctggctggccctggac
caaaagcttgaggcttcactgaagctaccaccggtgggcagcacagctagcctgtgtgtc
agccaggtccccgctgcacctgcccaccctcccctgaggaaggcctacagcttcgatcgg
aatctggggcagagtctcagtgaacctgcctgccactgccaccatgcggccactattgct
gcctgccgcagaccagaggctggaggaggtgccctgccccaggcatcccctactgtgcct
ccaccaggcagctctgaccccaggagcctcaacaggctacagctggtgctggcagagatg
gtggccacggagcgggagtatgtccgggctctagagtacactatggagaactatttcccc
gagctggatcgccccgatgtgccccagggcctccgcggtcagcgtgcccacctctttggc
aacctggagaagctgcgggacttccactgccacttcttcctgcgtgagctggaggcttgc
acccggcacccaccacgagtggcctatgccttcctgcgccatagggtgcagtttgggatg
tacgcgctctacagcaagaataagcctcgctccgatgccctgatgtcaagctatgggcac
accttcttcaaggacaagcagcaagcactgggggaccacctggacctggcctcctacctg
ctaaagcccatccagcgcatgggcaagtacgcactgctgctgcaggagctggcacgggcc
tgcgggggccccacgcaggagctcagtgcgctgcgggaggcccagagccttgtgcacttc
cagctgcggcacggaaacgacctgctggccatggacgccatccagggctgtgatgttaac
ctcaaggaacaggggcagctggtgcgacaggatgagtttgtggtgcgcactgggcgccac
aagtccgtgcgccgcatcttcctttttgaggagctgctgctcttcagcaagcctcgccat
gggcccacaggggttgacacatttgcctacaagcgctccttcaagatggcagaccttggt
ctcactgagtgctgtgggaacagcaacctgcgcttcgagatctggttccgccgccgcaag
gccagggacacctttgtgctgcaggcctccagcctggctatcaagcaggcctggacagct
gacatctcccacctgctttggaggcaggccgtccacaacaaggaggtgcgcatggctgag
atggtgtccatgggtgtggggaacaaggccttccgagacattgctcccagcgaggaagcc
atcaacgaccgcaccgtcaactatgtcctgaagtgccgagaagttcgctctcgggcgtcc
attgccgtagccccgtttgaccatgacagcctctacctgggggcctcgaactcccttcct
ggagaccctgcctcttgctctgttctggggtccctcaacctgcacctgtacagagaccca
gctcttctgggtctccgctgtcccctgtatcccagcttcccagaggaagcagcactggag
gctgaggcagagctgggcggccagccctctttgactgctgaggactcagagatctcgtcc
caatgcccatcagccagtggctccagtggctctgacagcagctgtgtgtcagggcaggcc
ctgggtaggggcctggaggacttaccctgtgtct

Protein Sequence

>PLEKHG4
MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEE
LQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGES
DTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCL
LAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPR
PEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQ
LPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKA
VPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTA
MDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEA
GEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTE
FSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPD
LPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCV
SQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVP
PPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFG
NLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGH
TFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHF
QLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRH
GPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTA
DISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRAS
IAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALE
AEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV

  • Gold
  • Silver
  • Bronze
  • IntAct