Field Data
UniProt Accession: Q5T5U3
Gene Name: ARHGAP21
Gene Synonim: ARHGAP10, KIAA1424
GAP/GEF: GAP
Description: Rho GTPase-activating protein 21 (Rho GTPase-activating protein 10) (Rho-type GTPase-activating protein 21)
Keywords: 3D-structure;Alternative splicing;Cell junction;Complete proteome;Cytoplasm;Cytoplasmic vesicle;Cytoskeleton;GTPase activation;Golgi apparatus;Isopeptide bond;Membrane;Methylation;Phosphoprotein;Polymorphism;Reference proteome;Ubl conjugation
Entrez ID: 57584
Ensembl Gene ID: ENSG00000107863
Ensembl Protein ID: ENSP00000379709
Our Specificity RhoA
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0016020membrane
GO:0015629actin cytoskeleton
GO:0031410cytoplasmic vesicle
GO:0005829cytosol
GO:0005856cytoskeleton
GO:0000139Golgi membrane
GO:0030659cytoplasmic vesicle membrane
GO:0005886plasma membrane
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007030Golgi organization
GO:0043547positive regulation of GTPase activity
GO:0072384organelle transport along microtubule
GO:0007165signal transduction
GO:0051683establishment of Golgi localization
GO:0051684maintenance of Golgi location

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: golgi, plasma_membrane
Localization in the literature: Golgi plasma membrane (junctions)

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP21
atggacaagctcaaggcctgcgaggtctcaaaaaataaagatggaaaagaacaaagtgaa
actgtatcactgtctgaagatgaaacattctcctggccaggtcccaaaacagttacgttg
aaaagaacatctcaaggctttggttttacattaagacattttattgtttatcccccagag
tctgcaattcaattttcatataaggatgaagaaaatggaaacagaggaggaaaacaaaga
aaccgcttggaaccaatggataccatatttgttaagcaagttaaagaaggaggacctgct
tttgaagctggattatgtacaggtgaccgaattataaaagtcaatggagaaagtgttatt
ggcaaaacctattcccaagtaattgctttaattcaaaacagtgatacaacattggaactt
agtgttatgccaaaagatgaagacattctccaagtgctacagtttacaaaggatgtcaca
gcactggcatattctcaagatgcctacctgaaaggcaacgaagcttatagcggcaatgcc
cgcaatatacctgaacctccaccaatctgctatccctggctgccatctgccccatcagcc
atggcacagccagttgaaatatctcctcctgactcatcattgagcaaacagcaaaccagt
acaccagtactgacacaacctggtagggcctatagaatggaaatacaagtgcctccatca
ccaacagatgttgcaaaatcaaacacagcagtgtgtgtttgcaatgaaagtgtaaggact
gtcattgtgccttctgagaaggttgtagatttgttatccaatagaaacaaccatacaggt
ccttcacatagaactgaagaagtgaggtatggcgtgagtgagcagacctctttaaaaaca
gtgtcaagaaccacatcaccaccattatcaattcccaccactcatctaattcatcagcct
gcaggctccagatcactggaaccttctggaattttacttaagtctggaaattacagtgga
cattctgatggaatctcaagcagcagatctcaagctgtggaggctccctctgtatctgtt
aatcactattcgccaaattcccatcagcacatagactggaaaaactataaaacttacaaa
gagtatattgataacagacgattgcacataggttgtcggacaatacaagaaagattagat
agtttaagagcagcatctcaaagcacgacagattataaccaggtcgtccccaaccgcact
actttgcagggacgacgtcgaagcacctctcatgatcgagtgccccagtctgtccagata
cggcaacgcagtgtgtcccaagaaagactggaagattctgtgctaatgaagtattgtcca
agaagtgcatctcaaggagcactgacgtctccatctgttagttttagtaatcatagaact
cgttcatgggattatattgagggacaggatgaaaccttagaaaatgtcaattctggaact
ccaatacctgattccaatggagagaaaaaacagacttacaagtggagtgggtttactgaa
caggatgatagacgaggtatttgtgaaagacctaggcagcaagaaattcataaatctttt
cgaggttccaattttactgtggctccaagcgttgttaattctgataacaggcgaatgagt
ggtagaggagtgggatctgtgtcgcagtttaaaaaaattccaccagatctaaaaacattg
cagtcaaacagaaattttcagactacttgtggaatgtcactgcctcggggtatttcacaa
gacaggtcacctcttgtgaaagtccgaagtaattctctgaaagctccttccacgcatgtc
acaaaaccatcatttagccagaaatcatttgtttctatcaaagaccaaagaccagtaaat
cacttgcatcagaacagtctgttgaatcagcagacatgggtaaggactgacagtgccccc
gatcagcaagtggagactgggaaatccccctctttatctggagcctctgccaagcctgcc
cctcagtcgagtgaaaacgctggtacttcagatttagaactacctgtcagtcaaaggaat
caagatttaagtttacaagaggctgaaactgagcaatcagatactttagataataaagaa
gctgtcatcctaagggaaaaacctccatctggacgccagacaccgcagcctttaaggcat
cagtcttacatcttggcagtaaatgaccaggagaccgggtcagacactacctgctggctg
cccaatgatgcacgtcgagaggtccacataaaaagaatggaggaaagaaaagcctcgagt
accagtccgcctggcgattctttggcttccatcccatttatagatgaaccaactagccct
agcattgatcatgatattgcacatatccctgcctctgctgttatatcagcctctacctct
caggtcccctccatagcaacagttcctccttgcctcacaacttcagctccattaattcgc
cgtcagctctcacatgaccacgaatctgttggccctcctagcctggatgctcagcccaac
tcaaagacagaaagatcaaaatcatatgatgagggtctggatgattacagagaagatgca
aaattgtcctttaagcacgtatctagtctgaagggaatcaagatcgcagacagccaaaag
tcatcagaagactctgggtccagaaaagattcttcctcagaggtcttcagtgatgctgcc
aaggaagggtggcttcatttccgaccccttgtcaccgataagggcaagcgagttggtgga
agtattcggccatggaaacagatgtatgttgtccttcggggtcattcactttacctgtac
aaagataaaagagagcagacgactccgtctgaggaagagcagcccatcagtgttaatgct
tgcttgatagacatctcttacagtgagaccaagaggaaaaatgtgtttcgactcaccacg
tccgactgtgaatgcctgtttcaggctgaagacagagatgatatgctagcttggatcaag
acgatccaggagagcagcaacctaaacgaagaggacactggagtcactaacagggatcta
attagtcgaagaataaaagaatacaacaatctgatgagcaaagcagaacagttgccaaaa
acacctcgccagagtctcagcatcaggcaaactttgcttggtgctaaatcagagccaaag
actcaaagcccacactctccgaaggaagagtcggaaaggaaacttctcagtaaagatgat
accagtcccccaaaagacaaaggcacatggagaaaaggcattccaagtatcatgagaaag
acatttgagaaaaagccaactgctacaggaactttcggcgtccgactagatgactgccca
ccagctcatactaatcggtatattccattaatagttgacatatgttgcaaattagttgaa
gaaagaggtcttgaatatacaggtatttatagagttcctggaaataatgcagccatctca
agtatgcaagaagaactcaacaagggaatggctgatattgatatacaagatgataaatgg
cgagatttgaatgtgataagcagtttactaaaatccttcttcagaaaactccctgagcct
ctcttcacaaatgataaatatgctgattttattgaagccaatcgtaaagaagatcctcta
gatcgtctgaaaacattaaaaagactaattcacgatttgcctgaacatcattatgaaaca
cttaagttcctttcagctcatctgaagacagtggcagaaaattcagaaaaaaataagatg
gaaccaagaaacctagcaatagtgtttggtcccacccttgttcgaacatcagaagacaac
atgacccacatggtcacccacatgcctgaccagtacaagattgtagaaacgctcatccag
caccatgactggtttttcacagaagaaggtgctgaagagcctcttacaacagtgcaggag
gaaagcacagtagactcccagccagtgccaaacatagatcatttactcaccaacattgga
aggacaggagtctccccaggagatgtatcagattcagctactagtgactcaacaaaatct
aagggttcttggggatctggaaaggatcagtatagcagggaactgcttgtgtcctccatc
tttgcagctgctagtcgcaagaggaagaagccgaaagaaaaagcacagcctagcagctca
gaagatgaactggacaatgtattttttaagaaagaaaatgtggaacagtgtcacaatgat
actaaagaggagtccaaaaaagaaagtgagacactgggcagaaaacagaagatcatcatt
gccaaagaaaacagcactaggaaagaccccagcacgacaaaagatgaaaagatatcacta
ggaaaagagagcacgccttctgaagaaccctcaccaccacacaactcaaaacacaacaag
tcaccaactctcagctgtcgctttgccatcctgaaagagagccccaggtcacttctggca
cagaagtcctcccaccttgaagagacaggctctgactctggcactttgctcagcacgtct
tcccaggcctccctggcaaggttttccatgaagaaatcaaccagtccagaaacgaaacat
agcgagtttttggccaacgtcagcaccatcacctcagattattccaccacatcgtctgct
acatacttgactagcctggactccagtcgactgagccctgaggtgcaatccgtggcagag
agcaagggggacgaggcagatgacgagagaagcgaactcatcagtgaagggcggcctgtg
gaaaccgacagcgagagcgagtttcccgtgttccccacagccttgacttcagagaggctt
ttccgaggaaaactgcaagaagtgactaagagcagccggagaaattctgaaggaagtgaa
ttaagttgcaccgagggaagtttaacatcaagtttagatagccggagacagctcttcagt
tcccataaactcatcgaatgtgatactctttccaggaaaaaatcagctagattcaagtca
gatagtggaagtctaggagatgccaagaatgagaaagaagcaccttcgttaactaaagtg
tttgatgttatgaaaaaaggaaagtcaactgggagtttactgacacccaccagaggcgaa
tccgaaaaacaggaacccacatggaaaacgaaaatagcagatcggttaaaactgagaccc
agagcccctgcggatgacatgtttggagtagggaatcacaaagtgaatgccgagactgct
aaaaggaaaagcatccggcgcagacatacactaggagggcacagagatgctaccgaaatc
agcgttttgaatttttggaaagtgcatgagcagagcggggagagagaatctgaactttca
gctgtaaaccggttaaaaccaaaatgctcagcccaggacctttccatctcagactggctg
gccagggaacgcctacgcaccagtacctctgaccttagcagaggagaaatcggagatccc
cagacagagaacccaagcacacgagaaatagccacgaccgacacacctttgtctcttcat
tgcaacacaggcagttcttccagcaccttggcttcaacaaacaggccccttctttccata
ccaccacagtcacctgaccaaataaacggagaaagcttccagaacgtgagcaaaaatgct
agttctgcagcgaatgcccaacctcataaactgtctgaaaccccaggcagtaaagcagag
tttcatccctgtcttttaatta

Protein Sequence

>ARHGAP21
MDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGFGFTLRHFIVYPPE
SAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVI
GKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNA
RNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPS
PTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEEVRYGVSEQTSLKT
VSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISSSRSQAVEAPSVSV
NHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSTTDYNQVVPNRT
TLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPSVSFSNHRT
RSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGICERPRQQEIHKSF
RGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQTTCGMSLPRGISQ
DRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLLNQQTWVRTDSAP
DQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEAETEQSDTLDNKE
AVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASS
TSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTSAPLIR
RQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQK
SSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLY
KDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLFQAEDRDDMLAWIK
TIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPK
TQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCP
PAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKW
RDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYET
LKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQ
HHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDVSDSATSDSTKS
KGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHND
TKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNK
SPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPETKH
SEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPV
ETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFS
SHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGE
SEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRRRHTLGGHRDATEI
SVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDP
QTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQINGESFQNVSKNA
SSAANAQPHKLSETPGSKAEFHPCLLI

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  • IntAct