Field Data
UniProt Accession: Q5TB30
Gene Name: DEPDC1
Gene Synonim:
GAP/GEF: GAP
Description: DEP domain-containing protein 1A
Keywords: 3D-structure;Alternative splicing;Complete proteome;GTPase activation;Nucleus;Phosphoprotein;Polymorphism;Reference proteome;Repressor;Transcription;Transcription regulation
Entrez ID: 55635
Ensembl Gene ID: ENSG00000024526
Ensembl Protein ID: ENSP00000412292
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005634nucleus
GO:0017053transcriptional repressor complex

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0006355regulation of transcription, DNA-templated
GO:0045892negative regulation of transcription, DNA-templated
GO:0006351transcription, DNA-templated
GO:0035556intracellular signal transduction
GO:0007165signal transduction

Reactome

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: nucleus

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>DEPDC1
atggagcgtcagggtgctcctcttggaccttaccgggccaccaagctgtggaatgaagta
accacatcttttcgagtaggaatgcctttaagaaaacatagacaacatttaaaaaaatat
agcaattgtttcactgcagttgaagctatagattggctttatgatctgttaagaagtaat
agtaattttggtcctgaagttacaagacaacagactattcaactattgagaaaatttctt
aagaatcatgtgattgaagatatcaaaggtagatggggatcggaaagccttgatgacaac
aatcaactattcagatttcctgcaacttctccacttaaaacttttccacaaagacataca
gaaatcaagaaaaccaacacagagtacttttccaaagacaaagatggtatttttaaatta
cgaaacttatctcaaaaaacttctaagaagcgtggattacatttctctcaggaaaataca
gaaaagataaatcatgaaagaataaccaatgaagatctagaaattgcacctgacaaccaa
gaaataagccaggaagatgttgaagaagtttggagatacgttattatgatatacctgcaa
accattttaagtttgccatccatagaagaactcttaaacccaaaccaagtaattcctcaa
tatataatgtacaacatggccaacacaagtaagcatggagtggtcatactacaagacaaa
tcagacgatcttccacattgggttttatctgcaatgaagtgcctagcaaattggccaaga
agtaatgacaccaataatctaacttatgttggatttgaacgtgatgtattcaaaacaatt
gcagattattttctaaatctccctgaacctctacttacatttgaatattatgaattattt
gtgaacattttggttgtttgtggctacatcacagtttcagatagaacaagtggaatacat
aaaatacaagatgatccacgatcttcaaaaatccatgatttaagcaatttgaattccttc
aaatcaactgagtgtcttcttctcagtctgctttacaaagacaaaagcaatgaagagttg
gattctactaaaagactacaaagaaatgatcaaggatttcaagaaagatgtgccaagaaa
atgcagctagataatttaagaaacagaagagctagtgctaatgacataatgggaggaagc
tgtcataatttaataggcttaagtaatacaaatgccctgtcctctaacatcaaaccaagg
tgctcttctttggaaggaattgtagataggccagtgaattcaagtgaaaagaagtccagt
atcttctaccagtctgttctgaacatagaagaacaaaatagtaagcaatcgttagtgtct
gcacccaaacagacacccctatttaatcttcactcagatgaaaatgctcagcagccacac
tgtgttggttttaacagaacctctgctttgactgttcaagaccaagaagagttatgtaat
gaaaagtataagtcaaaacagctttgtagatctcagagtttacttttaagaagtagtaca
agacagaatagttgtatcaataaaccagtggctgaaattataatgaaaccaaatgttgga
caagggagtacaagtgagctcggagagtctagtaccacaatcaataaaagactgtgcaaa
agcaccatagaactttcagagaaatctttacctccagctgcttctgtgttgactggcaca
caaagtttgctgcaacctcacttagagagggttgccatcaatgctctacagttatgttgt
ttgttacttcccccaccaaatcgtagaaagcttcaactcttaatgcgcatgatttctaga
atgagtcaaaatgttgatatgcccaaacttcatgaacaaataggtacaagatcattgatg
ataaatactttttctcgatgtgtactatgttgtgctgaagaagtggatcttgatgagctt
ctggcttcaagattagtttctttcctaatggatcatcatcaggaaattcttcaagtaccc
acttatttacaagctgcagtggagaaacatcttgactacattaaaaagggcaatgttaaa
aatcatggagatggactagttgttcctttgccaacatattcttactgtaaacagattagt
gctaaagaatttgatgaacagaaaatttcaacttcccaagctgcaattgcagaacttttg
gagaatattgtcagaagtaaaagcttgtctctaaaggagaaaagaagaaaattgaaacag
aaggaataccccttgatatatcagaaaagatttccaaccactgagagtgaagcagcactt
tttgatgataaacctacaatcaagcaaccgatgctgaatttaagaaaccccaagcttcac
agtctgcgttacttaatta

Protein Sequence

>DEPDC1
MERQGAPLGPYRATKLWNEVTTSFRVGMPLRKHRQHLKKYSNCFTAVEAIDWLYDLLRSN
SNFGPEVTRQQTIQLLRKFLKNHVIEDIKGRWGSESLDDNNQLFRFPATSPLKTFPQRHT
EIKKTNTEYFSKDKDGIFKLRNLSQKTSKKRGLHFSQENTEKINHERITNEDLEIAPDNQ
EISQEDVEEVWRYVIMIYLQTILSLPSIEELLNPNQVIPQYIMYNMANTSKHGVVILQDK
SDDLPHWVLSAMKCLANWPRSNDTNNLTYVGFERDVFKTIADYFLNLPEPLLTFEYYELF
VNILVVCGYITVSDRTSGIHKIQDDPRSSKIHDLSNLNSFKSTECLLLSLLYKDKSNEEL
DSTKRLQRNDQGFQERCAKKMQLDNLRNRRASANDIMGGSCHNLIGLSNTNALSSNIKPR
CSSLEGIVDRPVNSSEKKSSIFYQSVLNIEEQNSKQSLVSAPKQTPLFNLHSDENAQQPH
CVGFNRTSALTVQDQEELCNEKYKSKQLCRSQSLLLRSSTRQNSCINKPVAEIIMKPNVG
QGSTSELGESSTTINKRLCKSTIELSEKSLPPAASVLTGTQSLLQPHLERVAINALQLCC
LLLPPPNRRKLQLLMRMISRMSQNVDMPKLHEQIGTRSLMINTFSRCVLCCAEEVDLDEL
LASRLVSFLMDHHQEILQVPTYLQAAVEKHLDYIKKGNVKNHGDGLVVPLPTYSYCKQIS
AKEFDEQKISTSQAAIAELLENIVRSKSLSLKEKRRKLKQKEYPLIYQKRFPTTESEAAL
FDDKPTIKQPMLNLRNPKLHSLRYLI

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