Field Data
UniProt Accession: Q68EM7
Gene Name: ARHGAP17
Gene Synonim: RICH1
GAP/GEF: GAP
Description: Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
Keywords: Alternative splicing;Cell junction;Complete proteome;Cytoplasm;GTPase activation;Membrane;Phosphoprotein;Reference proteome;SH3-binding;Tight junction
Entrez ID: 55114
Ensembl Gene ID: ENSG00000140750
Ensembl Protein ID: ENSP00000303130
Our Specificity
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0005634nucleus
GO:0016020membrane
GO:0005886plasma membrane
GO:0005923bicellular tight junction
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0017124SH3 domain binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Kegg ID Description
hsa04530Tight junction
Field Data
Localization in this study: plasma_membrane
Localization in the literature: plasma membrane endoplasmic reticulum

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP17
atgaagaagcagttcaaccgcatgaagcagctggctaaccagaccgtgggcagagctgag
aaaacagaagtccttagtgaagatctattacagattgagagacgcctggacacggtgcgg
tcaatatgccaccattcccataagcgcttggtggcatgtttccagggccagcatggcacc
gatgccgagaggagacacaaaaaactgcctctgacagctcttgctcaaaatatgcaagaa
gcatcgactcagctggaagactctctcctggggaagatgctggagacgtgtggagatgct
gagaatcagctggctctcgagctctcccagcacgaagtctttgttgagaaggagatcgtg
gaccctctgtacggcatagctgaggtggagattcccaacatccagaagcagaggaagcag
cttgcaagattggtgttagactgggattcagtcagagccaggtggaaccaagctcacaaa
tcctcaggaaccaactttcgggggcttccatcaaaaatagatactctaaaggaagagatg
gatgaagctggaaatagagtagaacagtgcaaggatcaacttgcagcagacatgtacaac
tttatggccaaagaaggggagtatggcaaattctttgttacgttattagaagcccaagca
gattaccatagaaaagcattagcagtcttagaaaagaccctccccgaaatgcgagcccat
caagataagtgggcggaaaaaccagcctttgggactcccctagaagaacacctgaagagg
agcgggcgcgagattgcgctgcccattgaagcctgcgtcatgctgcttctggagacaggc
atgaaggaggagggccttttccgaattggggctggggcctccaagttaaagaagctgaaa
gctgctttggactgttctacttctcacctggatgagttctattcagacccccatgctgta
gcaggtgctttaaaatcctatttacgggaattgcctgaacctttgatgacttttaatctg
tatgaagaatggacacaagttgcaagtgtgcaggatcaagacaaaaaacttcaagacttg
tggagaacatgtcagaagttgccaccacaaaattttgttaactttagatatttgatcaag
ttccttgcaaagcttgctcagaccagcgatgtgaataaaatgactcccagcaacattgcg
attgtgttaggccctaacttgttatgggccagaaatgaaggaacacttgctgaaatggca
gcagccacatccgtccatgtggttgcagtgattgaacccatcattcagcatgccgactgg
ttcttccctgaagaggtggaatttaatgtatcagaagcatttgtacctctcaccaccccg
agttctaatcactcattccacactggaaacgactctgactcggggaccctggagaggaag
cggcctgctagcatggcggtgatggaaggagacttggtgaagaaggaaagtcctcccaaa
ccgaaggaccctgtatctgcagctgtgccagcaccagggagaaacaacagtcagatagca
tctggccaaaatcagccccaggcagctgctggctcccaccagctctccatgggccaacct
cacaatgctgcagggcccagcccgcatacactgcgccgagctgttaaaaaacccgctcca
gcacccccgaaaccgggcaacccacctcctggccaccccgggggccagagttcttcagga
acatctcagcatccacccagtctgtcaccaaagccacccacccgaagcccctctcctccc
acccagcacacgggccagcctccaggccagccctccgccccctcccagctctcagcaccc
cggaggtactccagcagcttgtctccaatccaagctcccaatcacccaccgccgcagccc
cctacgcaggccacgccactgatgcacaccaaacccaatagccagggccctcccaacccc
atggcattgcccagtgagcatggacttgagcagccatctcacacccctccccagactcca
acgccccccagtactccgcccctaggaaaacagaaccccagtctgccagctcctcagacc
ctggcagggggtaaccctgaaactgcacagccacatgctggaaccttaccgagaccgaga
ccagtaccaaagccaaggaaccggcccagcgtgcccccacccccccaacctcctggtgtc
cactcagctggggacagcagcctcaccaacacagcaccaacagcttccaagatagtaaca
gactccaattccagggtttcagaaccgcatcgcagcatctttcctgaaatgcactcagac
tcagccagcaaagacgtgcctggccgcatcctgctggatatagacaatgataccgagagc
actgccctgt

Protein Sequence

>ARHGAP17
MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGT
DAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIV
DPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFRGLPSKIDTLKEEM
DEAGNRVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAH
QDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLK
AALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL
WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA
AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERK
RPASMAVMEGDLVKKESPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQP
HNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPP
TQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNP
MALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPR
PVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSD
SASKDVPGRILLDIDNDTESTAL

  • Gold
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  • Bronze
  • IntAct