Field Data
UniProt Accession: Q6XZF7
Gene Name: DNMBP
Gene Synonim: KIAA1010
GAP/GEF: GEF
Description: Dynamin-binding protein (Scaffold protein Tuba)
Keywords: 3D-structure;Acetylation;Alternative splicing;Cell junction;Coiled coil;Complete proteome;Cytoplasm;Cytoskeleton;Golgi apparatus;Phosphoprotein;Polymorphism;Reference proteome;Repeat;SH3 domain;Synapse
Entrez ID: 23268
Ensembl Gene ID: ENSG00000107554
Ensembl Protein ID: ENSP00000315659
Our Specificity Cdc42
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0005856cytoskeleton
GO:0045202synapse
GO:0005795Golgi stack
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0035556intracellular signal transduction
GO:0007264small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: cytosolic, plasma_membrane
Localization in the literature: plasma membrane (junctions)

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DNMBP
atggaggctggctcagtggttcgagccatttttgacttctgccctagcgtatcagaagaa
ctgccgctctttgtgggagatattattgaggtgctggcagtggtggatgaattttggctt
ctaggaaagaaggaggatgttacaggacaattccccagcagttttgtggaaattgtgacc
attcccagtctaaaagagggagagaggctgtttgtgtgcatttgtgaattcacatcccaa
gagttggataatcttcccctccatcgaggtgacctggtgattctcgatggcattcccact
gcaggctggctgcagggccgaagctgctggggcgcacggggcttcttcccatcttcatgt
gtccgcgagctctgcctctcctcacagagccggcagtggcactcccagagcgccctgttt
cagattccggaatattccatgggacaagcccgggccctaatggggctttctgctcagctg
gatgaagagctggacttcagggaaggggatgtgatcaccattattggagttcctgaacca
ggctggtttgaaggggagttagagggccgaagaggcatttttccagaaggttttgtagag
ctgttggggcccctgaggactgtggatgagtcagtaagttctggaaatcaagatgactgc
attgttaatggtgaagtagatacccctgtaggagaagaagagatagggccggatgaggat
gaggaggagccagggacctatggggtcgccctgtacagattccaagccctggagccaaat
gagctggatttcgaggtcggggataaaatccgaattctggcgaccttggaagatggctgg
ctggaaggatccctgaagggcaggacaggcatctttccttaccggtttgtgaaattatgt
cctgacacacgggtggaggaaaccatggctctgccccaggaaggcagccttgccaggatc
ccggaaacttctttggattgtttggagaacaccttaggagtagaggaacaaagacatgaa
accagtgaccatggggccgaggagcctgactgcattatttctgaagcgcccacttctccc
ctcggtcatctgacttcagagtatgacacagacagaaactcttatcaggacgaggacacc
gcaggagggcccccgagaagcccaggcgtggagtgggaaatgcctcttgccacagactct
cccacatctgaccctacagaagtagtcaatggtatttcctcccaacctcaggtccctttt
catcccaacttgcagaaaagccagtattattctacagtgggagggagccacccgcactca
gaacagtaccctgaccttcttcccctagaagcaaggactagagactatgccagcctacct
cccaaaagaatgtattcccagctaaaaactcttcagaagccagtgctccctctttacagg
ggctcttctgtttcagcttcaagggtagtcaaacccagacaatcaagtcctcagctccac
aacctagcaagttatactaaaaagcaccacacgtccagtgtttactccatctcagagaga
ttggagatgaagcctggtccgcaagcccaagggcttgttatggaagcagcaacacattca
cagggagacggcagcactgacctggactcgaagctgacacaacagctgatcgagtttgag
aagagcttggcagggcccggcacagagccagataaaattttacgccacttttcaatcatg
gactttaactctgagaaggatattgtccgaggttcctcaaagttaatcaccgagcaggag
ctgccggaaaggagaaaggccctaaggccaccgccacctcgtccctgtactccggtatcc
acttctccccatttgctggttgaccagaacctaaaacctgcaccacccttggtggtgcga
ccctctcgcccagctcccctgcctccctcagcacagcagagaacgaatgcggtatccccc
aagctcctatctcgacaccgtcctacctgtgagaccttagaaaaggagggccctggtcat
atgggaaggagtctggaccagacctccccatgccccttagtgctggtgaggattgaggaa
atggagcgggacttggatatgtacagtagagctcaagaagagctaaacctcatgctggag
gagaagcaggatgaatcatcaagagcagagaccctcgaggatctcaagttctgtgaaagt
aacattgaaagtttgaatatggaactccagcaactaagagaaatgacgctcctctcctcc
cagtcttcatcactggtggccccttctgggtctgtgtctgccgaaaatccagagcagagg
atgctggagaagagagccaaggtcatagaagaacttcttcagacagaaagagactacatt
cgggatctggaaatgtgtattgagcggatcatggtacccatgcagcaggcacaggtacca
aacattgattttgagggactttttggaaatatgcagatggtgattaaggtctcgaagcaa
ttattggctgctctggaaatcagcgatgctgtaggacctgtgtttcttggtcaccgggat
gagcttgagggaacatacaagatttactgccagaatcatgatgaggccattgcgctgctt
gaaatctacgagaaggatgagaagatccagaagcatcttcaggactccttggcagatctg
aagagcctatacaacgaatggggatgcacaaattatattaacctgggctccttcctcatc
aaaccagtacagagagtaatgcgttacccgctgttgctaatggagttgctgaattccacc
ccagaatcccacccagataaagtgcctttaaccaatgcagtccttgcggtcaaggaaatc
aatgttaacattaatgaatataaacggcgaaaggacctggtcctcaagtaccgtaagggt
gatgaagatagccttatggagaaaatttccaaactgaacatccactccatcatcaagaaa
tccaaccgagttagcagtcacctgaagcatctcactggctttgctcctcagataaaagat
gaagtatttgaagaaacagaaaaaaacttccgaatgcaagaaagattgattaagtctttt
atccgagacctgtctctctacctccagcacatccgggagtccgcatgtgtgaaagtggtg
gctgctgtgagcatgtgggatgtgtgcatggagagaggacaccgggacctggagcagttt
gagagggtgcatcgccacatcagtgaccagctcttcacaaactttaaggagaggacagag
cggcttgtcatctcccccttaaatcagttactgagcatgtttacagggccccataagctg
gtacagaaacgctttgacaagctcctggacttctataactgtacagaacgggcagaaaag
ctaaaggacaggaagaccctggaggagctgcagtcggcccggaacaactatgaggccctg
aatgcacagctgctggatgagctgcccaagttccaccagtacgcccagggcctcttcacc
aactgtgtccacggctatgctgaagcccactgtgactttgtgcaccaggctctggagcaa
ttaaagccactgctttcgttactcaaagtggctggcagagagggaaaccttattgccatc
ttccacgaagagcacagcagagttctgcagcaactccaggtttttaccttcttcccggag
tctcttccagctaccaagaagccgtttgagaggaaaaccattgaccgccagtctgctcga
aagccactcctgggcctgccaagttacatgctacagtcagaagaactccgggcctccctc
ctggccaggtatccccctgaaaaactcttccaggcagaacggaacttcaatgctgctcaa
gacttggatgtctcacttttggaaggtgacctggtgggtgtgattaagaaaaaagacccc
atgggcagccagaaccgctggctgattgacaatggagtcaccaaaggcttcgtgtacagc
tctttcctaaagccctacaatcctcgccgcagccactccgatgcctccgtgggtagccac
tcctccacagagtctgagcacggcagctcctcccccaggttcccacgccagaacagcggc
agcaccctgaccttcaaccccagcagcatggctgtatcctttacctcggggtcttgccag
aagcagcctcaagacgcatctcctccgccaaaagaatgggaccaaggaactctcagtgca
tccctaaatccgagtaattcagagagtagtccttccagatgcccttcagacccagactct
acctcccagccaaggtcaggggactctgcagatgtagctagagatgtaaagcaacccact
gccacgccgaggagctaccggaacttcaggcatccagaaatagttggctactccgtacca
ggacgaaatgggcaaagtcaagacctcgtcaaaggatgtgcaagaacagcccaggctccg
gaagacagaagtacagagccagatggcagtgaggcagaaggcaaccaggtctattttgct
gtctacaccttcaaggcacgaaacccaaatgagctgagcgtgtcagtcaatcagaaactc
aagatcctcgagtttaaagatgttacaggaaatacagagtggtggttagctgaggttaac
gggaagaagggctacgttccctccaattatatccgcaaaaccgagtacacct

Protein Sequence

>DNMBP
MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT
IPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSC
VRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEP
GWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDED
EEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLC
PDTRVEETMALPQEGSLARIPETSLDCLENTLGVEEQRHETSDHGAEEPDCIISEAPTSP
LGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPF
HPNLQKSQYYSTVGGSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYR
GSSVSASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHS
QGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQE
LPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSP
KLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLE
EKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQR
MLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQ
LLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADL
KSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEI
NVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKD
EVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQF
ERVHRHISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEK
LKDRKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQ
LKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSAR
KPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDP
MGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSG
STLTFNPSSMAVSFTSGSCQKQPQDASPPPKEWDQGTLSASLNPSNSESSPSRCPSDPDS
TSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKGCARTAQAP
EDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSVNQKLKILEFKDVTGNTEWWLAEVN
GKKGYVPSNYIRKTEYT

  • Gold
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  • Bronze
  • IntAct