Field Data
UniProt Accession: Q6ZSZ5
Gene Name: ARHGEF18
Gene Synonim: KIAA0521
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 18 (114 kDa Rho-specific guanine nucleotide exchange factor) (p114-Rho-GEF) (p114RhoGEF) (Septin-associated RhoGEF) (SA-RhoGEF)
Keywords: Alternative splicing;Cell membrane;Coiled coil;Complete proteome;Cytoplasm;Cytoskeleton;Disease mutation;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;Retinitis pigmentosa
Entrez ID: 23370
Ensembl Gene ID: ENSG00000104880
Ensembl Protein ID: ENSP00000352995
Our Specificity
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0045177apical part of cell
GO:0070062extracellular exosome
GO:0016324apical plasma membrane
GO:0005829cytosol
GO:0016020membrane
GO:0005886plasma membrane
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0030036actin cytoskeleton organization
GO:0043065positive regulation of apoptotic process
GO:0008360regulation of cell shape
GO:0035023regulation of Rho protein signal transduction
GO:0007264small GTPase mediated signal transduction
GO:0007179transforming growth factor beta receptor signaling pathway

Reactome

Reactome ID Description
R-HSA-2173791TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Kegg ID Description
hsa04530Tight junction
Field Data
Localization in this study: actin
Localization in the literature: actin plasma membrane (junctions)

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF18
atgacggtctctcagaaagggggtccccagccaacaccgagcccggctggccctgggacg
caactcggaccaatcacaggagagatggatgaagccgattctgcgtttttaaaatttaag
cagacagctgatgactctctgtcccttacatctccaaacaccgagtccatttttgtagaa
gatccctacaccgcctcgctgaggagtgagattgagtcagacggccacgagtttgaagct
gagtcctggagcctcgccgtggatgcagcctacgccaagaagcaaaagagggaggtggtg
aaaagacaagatgtcctttatgagctgatgcagacagaggtgcaccacgtgcggacgctc
aagatcatgctgaaggtgtactccagggccctgcaggaggagctgcagttcagcagcaag
gccattggccgcctcttcccatgcgctgacgacctgctggagacgcacagccacttcctc
gctcggctcaaggagcgccgccaggagtccctggaggagggcagtgaccggaattatgtc
atccagaaaatcggcgacctcctggttcagcagttttcaggtgaaaatggggagagaatg
aaagaaaagtacggtgtgttttgtagtggccacaatgaagctgttagtcattacaagttg
ctgcttcagcaaaacaagaaatttcaaaacttgatcaagaaaattggcaacttctccatc
gtgcggcggcttggcgtgcaggagtgcattctcctggttacacaacgcataaccaaatac
ccagtgctggtggagcgcatcatccagaacacggaagctggcactgaggactatgaagac
ctgacccaggccttgaacctcatcaaagatatcatctcacaagtggacgccaaggtcagt
gagtgtgagaagggccagcgcctcagggagatcgcagggaagatggacctgaagtcttcc
agcaaactcaagaacgggctcaccttccgcaaggaagacatgcttcagcggcagctccac
ctggagggcatgctatgctggaagaccacatcagggcgcttgaaagatatcctggctatc
ctgctgaccgacgtacttttgctgctacaagaaaaagatcagaaatacgtctttgcttct
gtggactcaaagccacccgtcatctcgttacaaaagctcatcgtgagggaagtggccaac
gaggagaaagcgatgtttctgatcagcgcctccttgcaagggccggagatgtatgaaatc
tacacgagctccaaagaggacaggaacgcctggatggcccacatccaaagggctgtggag
agctgccctgacgaggaggaggggcccttcagcctgcccgaagaggaaaggaaggtggtc
gaggcccgcgccacgagactccgggactttcaagagcggttgagcatgaaagaccagctg
atcgcacagagcctcctagagaaacagcagatctacctggagatggccgagatgggcggc
ctcgaagacctgccccagccccgaggcctattccgtggaggggacccatccgagaccctg
cagggggagctaattctcaagtcggccatgagcgagatcgagggcatccagagcctgatc
tgcaggcggctgggcagcgccaacggccaggcggaagacggaggcagctccacaggcccg
cccaggagggctgagaccttcgcgggctacgactgcacaaacagccccaccaagaatggc
agtttcaagaagaaagtcagcagcactgaccccaggccccgagactggcgaggcccccca
aacagcccggacttgaagctcagtgacagtgacattcctgggagctctgaggaatcgccg
caggtggtggaggcgccaggcacggaatccgatccccgtctgcccaccgtcctggagtcg
gagcttgtccagcggatccagacactgtcccagctgctcctgaaccttcaggcggtaatc
gcccaccaggacagctatgtggagacgcagcgggctgccatccaggagcgggagaagcag
ttccggctgcagtcgacgcgtgggaacctgctgctggagcaggagcggcaacgcaacttc
gagaagcagcgggaggagcgcgcggccctggagaagctgcagagccagctgcggcacgag
cagcagcgctgggagcgcgagcgccagtggcagcaccaggagctggagcgtgcgggcgcg
cggctgcaggagcgcgagggcgaggcgcggcagctacgcgagcggctggagcaggagcgg
gccgagctggagcgccagcgccaggcctaccagcacgacctggagcggctgcgcgaggcc
cagcgtgccgtggagcgcgagcgggagcgcctggagctgctgcgccgcctcaagaagcag
aacaccgcgccaggcgcgctgccgcccgacacactggccgaggcccagcccccaagccac
cctcccagcttcaacggggaagggctggagggccctcgggtgagcatgctgccatccggc
gtggggccagagtacgcagagcgccccgaggtggctcgccgggacagcgcccccaccgag
agccggctggccaagagcgatgtgcccatccagctgctcagcgccaccaaccagttccag
aggcaggcggccgtgcagcagcagatccccaccaagctggcggcctccaccaagggtggc
aaggacaagggcggcaagagcaggggctctcagcgctgggagagctcagcgtccttcgac
ctgaagcagcagctgctgctcaacaagctcatggggaaagatgagagcacctcacggaac
cgccgctcgctgagccctatcctgcccggcagacacagtcctgcgcccccaccagaccct
ggcttccccgccccgagcccaccgccagctgacagcccctccgagggcttctctctcaag
gccgggggcacagccctcctgcccggccccccagctccctcgccactgccggccacacca
ctcagcgccaaggaggacgccagcaaagaagacgtcatcttcttcttaatta

Protein Sequence

>ARHGEF18
MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE
DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL
KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV
IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI
VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS
ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI
LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI
YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL
IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI
CRRLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP
NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI
AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE
QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA
QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG
VGPEYAERPEVARRDSAPTESRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG
KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP
GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFFLI

  • Gold
  • Silver
  • Bronze
  • IntAct