Field Data
UniProt Accession: Q6ZUM4
Gene Name: ARHGAP27
Gene Synonim: CAMGAP1, SH3D20
GAP/GEF: GAP
Description: Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)
Keywords: 3D-structure;Alternative splicing;Complete proteome;Cytoplasm;Endocytosis;GTPase activation;Membrane;Phosphoprotein;Polymorphism;Reference proteome;Repeat;SH3 domain
Entrez ID: 201176
Ensembl Gene ID: ENSG00000276907
Ensembl Protein ID: ENSP00000487991
Our Specificity Rac1
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005634nucleus
GO:0016020membrane
GO:0005622intracellular
GO:0005654nucleoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0017124SH3 domain binding

Biological Process

GO ID Description
GO:0006898receptor-mediated endocytosis
GO:0006897endocytosis
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: pan troglodytes

Nucleotide Sequence

>ARHGAP27
atggcggcggacgtggtgggggacgtgtacgtgctggtggagcaccccttcgagtacacc
ggcaaggacgggcgccgcgtggccatccggccgaatgagcgctaccggctgctgcggcgc
agcaccgagcactggtggcacgtgcggcgtgagcccggcggccgccccttctacctgcct
gcgcagtacgtgcgcgagctgcccgcgctgggcaaccctgccgccgccgcgccgccaggt
ccccacccgagccccgcggcccctgagccgctcgcctacgactaccggtttgtgagcgcg
tctgcgaccgcgggccccgaaggcgcccccgaggagtccggaggccgagccagctccctg
tgcggccctgcgcaacgcggcgccgcgacccagcgcagcagcctggcgcccggcctgcca
gcctgcctgtacctgcggcccgcggcgcccgtgcggcccgcgcagtccctgaacgacctg
gcctgcgccgccgtctcgcctcccgccggcctcctaggaagcagcggcagcttcaaggcc
tgcagcgtggcgggctcctgggtgtgcccgcggcctctggcgcgcagcgactcagagaac
gtctacgaggtcatccaggacttgcacgtcccgccgcgggaggagagcgcagagcaggtg
gacgacccaccggagcccgtgtacgcgaacatagagaggcagccccgggccacttcaccg
ggcgccgctgcagcccctcttcccagcccggtgtgggagacgcacacggacgcgggcacc
gggcgcccctactactacaacccagacacgggagttaccacctgggagtcgccctttgag
gctgccgagggtgccgccagcccagccacctcccctgcctcggtggacagccacgtgagc
cttgagaccgagtggggccagtactgggatgaggagagccgcagggtgttcttctacaac
ccgctgacgggcgagacggcctgggaggacgaggccgagaacgagcccgaggaggagttg
gagatgcagccgggcctgagccctggcagcccaggggacccgcggccccccactcccgag
acggactaccccgagtcgctgaccagttaccccgaggaggactattctcccgtgggctct
ttcggtgagcccggccctacctctcccttgaccacaccccccggctggtcttgtcatgtc
agccaggacaagcagatgctctacaccaaccacttcacccaggagcagtgggtgaggctg
gaggacccccacgggaagccatacttctacaatccagaggactcctctgttcgatgggag
ctgccccaggtccctatccctgcccctcggagcatccataaatccagccaggatggtgac
accccagcccaggccagccctccagaggagaagaccaagaccttggacaaggcaggggtg
ctccatcgcaccaagacggcagacaagggaaagcggctccggaagaagcactggagtgcc
tcctggactgtgctggagggtggcgtcctgacattcttcaaggactcaaagacctcggct
gcaggcggcctgaggcagccttccaagttttccacccctgagtacacagtggagctgagg
ggggccactctctcctgggcccccaaagacaaatccagtaggaagaatgtgctggagcta
cggagccgagatggctccgagtacctgatccagcacgactcggaggccatcatcagcacc
tggcataaggccattgctcagggcatccaggagctgtccgcagagctgcccccagaggag
gagagcgagagcagcagagtggacttcgggtcgagtgagcgcttgggaagctggcaggag
aaagaggaggacgcgcgaccgaatgcagccgcgcccgccctgggccccgtgggcctggag
agcgacttgagcaaggtccggcacaagctccgcaagttcctccagaggcggcccacactg
cagtcgctgcgggagaagggctacatcaaagaccaggtgttcggctgcgcgctggccgcg
ctgtgtgagcgcgagaggagccgggtgccacgcttcgtgcagcagtgcatccgcgccgtc
gaggcccgcgggctggacatcgacgggctgtaccgcatcagtggaaacctggccaccatc
cagaagctacgctataaggtggaccacgatgagcgccttgacctggatgacgggcgctgg
gaggacgtccacgttatcaccggagccctgaagctcttctttcgggagctgcccgagccc
ctcttccccttctcgcacttccgccagttcattgcggccatcaagttgcaggaccaggcc
cggcgcagccgctgtgtgcgtgacttggtgcgctcgctgcccgcccccaaccacgacact
ctgcggatgctcttccagcacctctgccgggtgatcgagcacggcgagcagaaccgcatg
tcggtgcagagcgtggccattgtgttcgggcccacgctgctgcggcccgaggtggaagag
accagcatgcccatgaccatggtgttccagaaccaggtggtggagctcatcctgcagcag
tgcgcggacatcttcccgccgcacttaatta

Protein Sequence

>ARHGAP27
MAADVVGDVYVLVEHPFEYTGKDGRRVAIRPNERYRLLRRSTEHWWHVRREPGGRPFYLP
AQYVRELPALGNPAAAAPPGPHPSPAAPEPLAYDYRFVSASATAGPEGAPEESGGRASSL
CGPAQRGAATQRSSLAPGLPACLYLRPAAPVRPAQSLNDLACAAVSPPAGLLGSSGSFKA
CSVAGSWVCPRPLARSDSENVYEVIQDLHVPPREESAEQVDDPPEPVYANIERQPRATSP
GAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWESPFEAAEGAASPATSPASVDSHVS
LETEWGQYWDEESRRVFFYNPLTGETAWEDEAENEPEEELEMQPGLSPGSPGDPRPPTPE
TDYPESLTSYPEEDYSPVGSFGEPGPTSPLTTPPGWSCHVSQDKQMLYTNHFTQEQWVRL
EDPHGKPYFYNPEDSSVRWELPQVPIPAPRSIHKSSQDGDTPAQASPPEEKTKTLDKAGV
LHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELR
GATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEE
ESESSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTL
QSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLATI
QKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQA
RRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE
TSMPMTMVFQNQVVELILQQCADIFPPHLI

  • Gold
  • Silver
  • Bronze
  • IntAct