Field Data
UniProt Accession: Q6ZV73
Gene Name: FGD6
Gene Synonim: KIAA1362, ZFYVE24
GAP/GEF: GEF
Description: FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24)
Keywords: Alternative splicing;Complete proteome;Cytoplasm;Cytoskeleton;Guanine-nucleotide releasing factor;Metal-binding;Phosphoprotein;Polymorphism;Reference proteome;Repeat;Zinc;Zinc-finger
Entrez ID: 55785
Ensembl Gene ID: ENSG00000180263
Ensembl Protein ID: ENSP00000450342
Our Specificity
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0001726ruffle
GO:0005856cytoskeleton
GO:0030027lamellipodium

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0031267small GTPase binding
GO:0046872metal ion binding
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0007010cytoskeleton organization
GO:0043547positive regulation of GTPase activity
GO:0030036actin cytoskeleton organization
GO:0008360regulation of cell shape
GO:0035023regulation of Rho protein signal transduction
GO:0046847filopodium assembly
GO:0043087regulation of GTPase activity

Reactome

KEGG

Field Data
Localization in this study: actin
Localization in the literature: podosomes, vesicles

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>FGD6
atgacttctgccgcggagcttaagaagccaccattggctcccaagccaaagttagtgggg
accaataataagccacctccccctcctattgcacctaaaccggacattggcagtgctagt
gttccacggttaacgaagaagaccaaaccggcaattgcgccaaaaccaaaagtcccgaca
aactcagttgttcaagacattaagcatccaccctcaaagaaacctactttgaacctggag
gaaagggagccagaattacccgagagcactggcaagtctaattgcaaggatgtcagggat
ccacacagtgattatattttaccaacgtgttcctgcagttctgggtgtattcatgagcct
aggactcgagaaaccctgtgtgtagagcagcttgttttagagcctctgggaatgaaggaa
aatttagagaatagtaaaaatggtgagtcctcaaaaagggggagtagctgggattcaagc
agcgaaaagtgccggggccagagtggagttgttttaaaggcaagcatcttagaagagaag
ctcaaagaggtcctgacgcagcagcgatcaccttgtggttccccagggaggcacagagct
ccaaaaaaaccagaaatgaatggtgaccatagttgcaccaggcagatcagaattgaattt
gcagatgtgtcttcttccctgaccggctttgaaaaagttcccgctcatcacaactgccac
ccacaacttcctagggatgaatctcagactctcaagacttgtcaagatggcagtgcagag
agccatggtcacactgattcatgtgaaccggagaacaaaagagtggcttcagatggaatt
agtcagaagacagaggacaaaggtctcggtcctttagaaatccacttactaccgtatacc
tcaaagtttccaactcccaagcccaggaagacacacgcagctgctcgtcttcgccgccag
aagcatgtagatactcctggtgaaagcactgaagagccagggaactcaaacaatggctct
tcttgtctcctggaggatagtttgaaaaacaataaagtcagtgttcttcgtcagaatgct
ttgtataaccagggaccagcagacgaggtgaggccagcaaaccagagggcattgacaggg
gattccaacagtggcggacaggactcagtcggctcacagaaagctgtgcagcagcaaacg
ccttctttagatacagattctagtttgacttctgacagcagtggttctggcgtgtcacct
gctgtggacaaagagactacttacacacagtgcagtactcagcctttgagcttgcctaag
caagtcacatcagcctgcactgaccagccaccagctacctgtaacccggaagtgtcagct
cctcccatacaaaaggaatcttcctcctcgagaatcattcccaaaaaacctcaaagacac
agcttgcctgcagcaggggtgcttaaaaaggctgcttcggaggagcttgtagaaaagagc
tcttcaggtaaggagacaaatgtcgagaaaggtctgcacagaaaccaccttcaccatccg
gggcccccaaaccatggcgcgtcagcatcaccctttgatatgcccaacccgacttcagag
aagccagtgtggaagttacctcatcctattctacctttttcagggagcccagaggccttg
aaacgcgtcactttatccttaaataacgagccttccgtttccctaaccaagccaagagca
aaatccctgtctgccgtggatgcggaccggtgtaacaagccttgcaaagaccctccgaag
aaaacttcttttaaaaagttgatcaatgtgaaactgtccattggcttcataaagagcgac
tttcagaaaattaggtcgaaaagctgccaacacggggatgtctctacaggacatccgctc
gctagagagccaaaaggacttgaaagtgattggcaaggtttggccacaggagaagagaag
agaagtaagcccacgaaggcacattctgcagaaaactgcagcctggaatctcaaaaggtg
aagtcctggggccagagcagtgcagttaacggtcagagggcggagtctttggatgaccgg
attctctccaggcacacgtcctgtacaggcgacttcgggccagagtatgaaaatgtccgc
cattatgaggagatacccgagtatgagaatttgccctttgtcatggctggaaggaacact
ccggacttgggatggcagaactccagcagtgtggaggacactgatgcaagcctgtatgaa
gtggaagagccctacaatgctccagatggccagctgcaacttgatcctagacatcagcct
tgcagttctggaacatcccaggaggggcaggatgctctccatcttggcctcagtgacctg
ccttctgatgaggaagtcatcaatagttctgatgaagatgatgtcagctccgagtccagt
aaaggcgagccagaccccctggaagataaacaggatgaagatgctgggatgaaaagcaaa
gttcatcatattgccaaggagatcatgagctccgagaaagtgtttgtggatgtgttaaag
cttttgcatattgacttccggggtgctgtagcccatgcatccaggcaactcgggaagccc
gtgattgaggaccggatccttaaccagatcctgtactacctgcctcagctgtacgagctc
aaccgggatctcctgaaggaactggaagagcgaatgctcacctggacagaacaacaaaga
attgctgatatctttgtaaagaaggggccatacttaaaaatgtattccacatacatcaaa
gaatttgataagaacgtagctttgctggatgagcagtgcaagaaaaatccaggatttgct
gcagttgtcagagaattcgagatgagccctcgatgtgccaacctggccctgaagcactac
ctgctaaagccagttcagaggatccctcagtacaggctgctactgacagattacttaaag
aaccttctagaagactctgtagatcacagagacacccaagatgccctggctgttgtcata
gaggtagctaaccatgccaatgacaccatgaagcaaggggacaactttcagaagctcatg
cagattcagtacagcttaagtggacaccatgaaattgtgcaacctgggcgggtttttctt
aaagaaggcaccctgatgaagctgtctcggaaagtcatgcagccccggatgtttttcctg
tttaacgatgctcttctctacaccacacccatgcagtctgggatgtacaaactgaacaac
atgctctcgctggctggaatgaaggtcagaaaacctacccaggaggcatatcagaacgag
ttaaagattgaaagtgtagagcgttctttcatcctctcagctagttctgccgcagaaaga
gacgactggctggaggccatatccagctccatagaagagtatgccaagaaaagaatcaca
ttctgccccagcaggagtcttgatgaggactcagaaaggaaagaagaagttagccccctc
ggggcaaaggctcccatctggatcccagacaccagagccaccatgtgtatgatttgcaca
agtgaattcaccctgacctggagaagacaccactgcagggcctgtgggaagattgtgtgc
caagcttgctcatcaaacaagtatggcttagattacctgaaagggcaactggcaagagtg
tgcgagcactgcttccaagagctacagaaattagatcaccagctgtcgcctagggttggg
tctcccggaaatcacaagtctccttcaagtgccttgtcgtcagtcttacatagcatcccg
tcagggaggaagcagaagaaaatccccgctgctctcaaagaagtgtcagcaaacacagaa
gactccactatgagcggctacctctacagatccaagggcagtaaaaagccatggaaacac
ttatggtttgtcatcaaaaacaaagtactctacacatatgctgcaagcgaggacgtggca
gctttggaaagtcagcctttattaggcttcaccgtcactctagtcaaggatgagaactca
gagtctaaagtgtttcagctgctgcacaaaggcatggtgttttacgtatttaaggcagac
gatgcccactccacgcagaggtggatagacgcatttcaggaaggcacagtattgttaatt
a

Protein Sequence

>FGD6
MTSAAELKKPPLAPKPKLVGTNNKPPPPPIAPKPDIGSASVPRLTKKTKPAIAPKPKVPT
NSVVQDIKHPPSKKPTLNLEEREPELPESTGKSNCKDVRDPHSDYILPTCSCSSGCIHEP
RTRETLCVEQLVLEPLGMKENLENSKNGESSKRGSSWDSSSEKCRGQSGVVLKASILEEK
LKEVLTQQRSPCGSPGRHRAPKKPEMNGDHSCTRQIRIEFADVSSSLTGFEKVPAHHNCH
PQLPRDESQTLKTCQDGSAESHGHTDSCEPENKRVASDGISQKTEDKGLGPLEIHLLPYT
SKFPTPKPRKTHAAARLRRQKHVDTPGESTEEPGNSNNGSSCLLEDSLKNNKVSVLRQNA
LYNQGPADEVRPANQRALTGDSNSGGQDSVGSQKAVQQQTPSLDTDSSLTSDSSGSGVSP
AVDKETTYTQCSTQPLSLPKQVTSACTDQPPATCNPEVSAPPIQKESSSSRIIPKKPQRH
SLPAAGVLKKAASEELVEKSSSGKETNVEKGLHRNHLHHPGPPNHGASASPFDMPNPTSE
KPVWKLPHPILPFSGSPEALKRVTLSLNNEPSVSLTKPRAKSLSAVDADRCNKPCKDPPK
KTSFKKLINVKLSIGFIKSDFQKIRSKSCQHGDVSTGHPLAREPKGLESDWQGLATGEEK
RSKPTKAHSAENCSLESQKVKSWGQSSAVNGQRAESLDDRILSRHTSCTGDFGPEYENVR
HYEEIPEYENLPFVMAGRNTPDLGWQNSSSVEDTDASLYEVEEPYNAPDGQLQLDPRHQP
CSSGTSQEGQDALHLGLSDLPSDEEVINSSDEDDVSSESSKGEPDPLEDKQDEDAGMKSK
VHHIAKEIMSSEKVFVDVLKLLHIDFRGAVAHASRQLGKPVIEDRILNQILYYLPQLYEL
NRDLLKELEERMLTWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNVALLDEQCKKNPGFA
AVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLLEDSVDHRDTQDALAVVI
EVANHANDTMKQGDNFQKLMQIQYSLSGHHEIVQPGRVFLKEGTLMKLSRKVMQPRMFFL
FNDALLYTTPMQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSAAER
DDWLEAISSSIEEYAKKRITFCPSRSLDEDSERKEEVSPLGAKAPIWIPDTRATMCMICT
SEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVCEHCFQELQKLDHQLSPRVG
SPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSTMSGYLYRSKGSKKPWKH
LWFVIKNKVLYTYAASEDVAALESQPLLGFTVTLVKDENSESKVFQLLHKGMVFYVFKAD
DAHSTQRWIDAFQEGTVLLI

  • Gold
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  • Bronze
  • IntAct