Field Data
UniProt Accession: Q6ZW31
Gene Name: SYDE1
Gene Synonim:
GAP/GEF: GAP
Description: Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 85360
Ensembl Gene ID: ENSG00000105137
Ensembl Protein ID: ENSP00000470733
Our Specificity
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0051493regulation of cytoskeleton organization
GO:0090630activation of GTPase activity
GO:0007165signal transduction
GO:1901165positive regulation of trophoblast cell migration
GO:0043087regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: actin, focal_adhesions
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Positive

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>SYDE1
atggccgagccgctactcaggaaaaccttctcccgcctgcggggccgggagaaacttccc
cggaaaaagtcggacgccaaggagcgcggccacccagcccagcgcccagagcccagccct
ccagagccagagccccaggctcccgaagggtcccaggccggagcagaggggccctccagc
cccgaggcatcaaggagccctgcacggggagcctacctgcaaagcctggagcccagtagc
cgccgatgggtgctgggtggggccaagccagctgaggacacctctttagggcctggggta
cctggcactggggagcccgccggcgagatctggtacaaccccatccctgaggaagacccc
agacctccagcacctgagcccccggggccacagcctggctcagctgagtcagagggcctg
gccccccaaggtgcagcccccgccagccccccaaccaaagcctcccgcaccaagtccccg
ggccccgccaggcgcctctccataaagatgaagaagctgccggaactgcggcgccgcctg
agcctgcgaggcccccgggctggcagggagcgcgagagggctgcccctgcgggctccgtc
atcagccgctaccacctggacagcagcgtggggggccccgggccggcagcagggcctggg
ggcacccggagcccgagggccggttacctcagcgacggggactcaccggagcgcccagct
gggcccccatcacccacctccttccggccctacgaggtgggtcccgcagcccgggcaccc
ccggccgcactctggggccgcctcagcctgcacctgtacggtctcggggggctgcggcca
gcgccgggggccacccccagggacctctgctgcctactgcaagtggatggggaggccagg
gcccgaacagggccactgcgaggggggccggacttcctgcggctggaccacaccttccac
ctggagctggaggccgccaggctcctgcgcgccctggtgcttgcgtgggaccctggcgtg
agaaggcaccggccctgtgcccagggcaccgtgctgctgcccacggtcttccgagggtgc
caggcccaacagctggccgtgcgcctggagcctcaggggctgctgtatgccaagctgacc
ctgtcggagcagcaggaagcccctgccacagctgagccccgcgtctttgggctgcccctg
ccactgctggtggagcgggagcggccccccggccaggtgcccctcatcatccagaagtgc
gttgggcagatcgagcgccgagggctgcgggtagtgggactgtaccgtctttgtggctca
gcggcagtgaagaaagagcttcgggatgcctttgagcgggacagtgcagcggtctgccta
tctgaggacctgtaccccgatatcaatgtcatcactggcatcctcaaggattatcttcga
gagttgcccaccccactcatcacccaacccctgtataaggtggtactggaggccatggcc
cgggaccccccaaacagagttccccccaccactgagggcacccgagggctcctcagctgc
ctgccagatgtggaaagggccacgctgacgcttctcctggaccacctgcgcctcgtctcc
tccttccatgcctacaaccgcatgaccccacagaacttggccgtgtgcttcgggcctgtg
ctgctgccggcacgccaggcgcccacaaggcctcgtgcccgcagctccggcccaggcctt
gccagtgcagtggacttcaagcaccacatcgaggtgctgcactacctgctgcagtcttgg
ccagatccccgcctgccccgacaatctccagatgtcgcgccttacttgcgacccaaacga
cagccacctctgcacctgccgctggcagaccccgaagtggtgactcggccccgcggtcga
ggaggccccgaaagccccccgagcaaccgctacgccggcgactggagcgtttgcgggcgg
gacttcctgccttgtgggcgggatttcctgtccgggccagactacgaccacgtgacgggc
agtgacagcgaggacgaggacgaggaggtcggcgagccgagggtcaccggtgacttcgaa
gacgacttcgatgcgcccttcaacccgcacctgaatctcaaagacttcgacgccctcatc
ctggatctggagagagagctctccaagcaaatcaacgtgtgcctcttaatta

Protein Sequence

>SYDE1
MAEPLLRKTFSRLRGREKLPRKKSDAKERGHPAQRPEPSPPEPEPQAPEGSQAGAEGPSS
PEASRSPARGAYLQSLEPSSRRWVLGGAKPAEDTSLGPGVPGTGEPAGEIWYNPIPEEDP
RPPAPEPPGPQPGSAESEGLAPQGAAPASPPTKASRTKSPGPARRLSIKMKKLPELRRRL
SLRGPRAGRERERAAPAGSVISRYHLDSSVGGPGPAAGPGGTRSPRAGYLSDGDSPERPA
GPPSPTSFRPYEVGPAARAPPAALWGRLSLHLYGLGGLRPAPGATPRDLCCLLQVDGEAR
ARTGPLRGGPDFLRLDHTFHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGC
QAQQLAVRLEPQGLLYAKLTLSEQQEAPATAEPRVFGLPLPLLVERERPPGQVPLIIQKC
VGQIERRGLRVVGLYRLCGSAAVKKELRDAFERDSAAVCLSEDLYPDINVITGILKDYLR
ELPTPLITQPLYKVVLEAMARDPPNRVPPTTEGTRGLLSCLPDVERATLTLLLDHLRLVS
SFHAYNRMTPQNLAVCFGPVLLPARQAPTRPRARSSGPGLASAVDFKHHIEVLHYLLQSW
PDPRLPRQSPDVAPYLRPKRQPPLHLPLADPEVVTRPRGRGGPESPPSNRYAGDWSVCGR
DFLPCGRDFLSGPDYDHVTGSDSEDEDEEVGEPRVTGDFEDDFDAPFNPHLNLKDFDALI
LDLERELSKQINVCLLI

  • Gold
  • Silver
  • Bronze
  • IntAct