Field Data
UniProt Accession: Q7Z5H3
Gene Name: ARHGAP22
Gene Synonim: RHOGAP2
GAP/GEF: GAP
Description: Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)
Keywords: Alternative splicing;Angiogenesis;Coiled coil;Complete proteome;Cytoplasm;Developmental protein;Differentiation;GTPase activation;Nucleus;Phosphoprotein;Polymorphism;Reference proteome;Transcription;Transcription regulation
Entrez ID: 58504
Ensembl Gene ID: ENSG00000128805
Ensembl Protein ID: ENSP00000416701
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005634nucleus
GO:0005925focal adhesion
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0030154cell differentiation
GO:0006355regulation of transcription, DNA-templated
GO:0006351transcription, DNA-templated
GO:0001525angiogenesis
GO:0007275multicellular organism development
GO:0007165signal transduction

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions, plasma_membrane
Localization in the literature: vesicles cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP22
atgctgagcccaaagatcaggcaggccaggagggcccgctccaaaagcctagtgatgggg
gagcagagccggagccctgggcggatgccgtgccctcacaggctgggccccgtgctgaag
gcgggctggctgaagaagcagaggagcatcatgaagaactggcagcagcgctggtttgtg
ctgcgtggggatcagcttttctactacaaggacaaagatgagatcaagccccagggattt
atttctctacaagggacacaggtgactgaacttcctcctggccccgaggacccagggaag
cacctctttgagatcagcccaggtggtgctggggagcgggagaaggtgccggccaacccc
gaggcgctcctgctcatggccagctcccagcgtgacatggaggactgggtgcaggccatc
cgccgagtcatctgggccccgctgggcggaggtactgcccgtagatcgcatgcccaccct
ctagaacccttgcctccagggatctttgggcagcgcctagaggaaacagtccaccacgag
cggaagtatggcccccgcctggcgcccctgctggtggagcagtgtgtggacttcatccgg
gagcgcgggctcactgaggaggggctgttccgcatgccgggccaggccaacctggtgagg
gacctgcaggattccttcgactgtggggagaagccactgtttgacagcacaacagacgtg
cacacggtggcctccctgctgaagctgtacctgcgggagctccccgagcccgtggtcccc
ttcgccaggtacgaggacttcctcagctgcgcccagctgctcaccaaggacgagggggag
ggcactctggagttggctaaacaagtgagcaaccttcctcaggcaaattacaacctgctc
agatacatctgcaagtttctggatgaagttcaggcatactcaaatgtcaacaagatgagt
gtccagaatctggcaaccgtttttggacctaacattctgcggccacaggtagaggaccca
gtaaccatcatggaaggcacttccctcgtccagcacctgatgaccgtcctcatccgcaaa
cacagccagctcttcacggcaccggtcccggaagggcccacctccccgcgcgggggcctg
caatgcgcagtggggtggggctccgaggaggtcaccagggacagccaaggagagcccggc
ggccccggcctgcccgcgcacaggacctcttccctggacggggcggccgtggcggtgctc
tccagaacagcccccacggggccggggagccggtgcagccctgggaagaaggtgcagacc
ctgcccagttggaagtcctccttccggcagccgaggtccctatcgggaagcccgaagggg
ggcggctcatccctggaggtgcccatcatctcctccggcgggaactggcttatgaacggg
ctgtcctccctgcgcggacaccgccgggcctcgtcgggagaccggctcaaggactcgggc
tccgtgcagagactctccacctacgacaatgtgcccgcgccgggcctggtccccggcata
cccagcgtggccagtatggcgtggtccggggcctcgtccagcgagtcgtcggtggggggc
tcactcagcagctgcacggcctgccgcgccagcgactcgtctgcccgcagttccctgcac
accgactgggccctggagccctccccgctccccagcagcagcgaggaccccaagtccctg
gacctggaccacagcatggacgaggcgggcgcgggtgccagcaacagcgagcccagcgag
ccggacagccccacccgggaacacgcgcgccgctccgaggccttacaggggctggtcact
gagctcagggccgagctgtgccgccagcggactgagtacgagaggagtgtgaaaagaatc
gaagaagggagtgctgacctgagaaaacgaatgtcccggttagaagaagaactggaccag
gaaaagaaaaaatacatcatgctggaaataaagctgcggaactctgaacgggcgcgggag
gatgcggagaggaggaaccagctgttgcagagggaaatggaggagtttttttcgacccta
ggaagcttgactgttggggcaaaaggtgccagggccccaaagt

Protein Sequence

>ARHGAP22
MLSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFV
LRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANP
EALLLMASSQRDMEDWVQAIRRVIWAPLGGGTARRSHAHPLEPLPPGIFGQRLEETVHHE
RKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDV
HTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLL
RYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRK
HSQLFTAPVPEGPTSPRGGLQCAVGWGSEEVTRDSQGEPGGPGLPAHRTSSLDGAAVAVL
SRTAPTGPGSRCSPGKKVQTLPSWKSSFRQPRSLSGSPKGGGSSLEVPIISSGGNWLMNG
LSSLRGHRRASSGDRLKDSGSVQRLSTYDNVPAPGLVPGIPSVASMAWSGASSSESSVGG
SLSSCTACRASDSSARSSLHTDWALEPSPLPSSSEDPKSLDLDHSMDEAGAGASNSEPSE
PDSPTREHARRSEALQGLVTELRAELCRQRTEYERSVKRIEEGSADLRKRMSRLEEELDQ
EKKKYIMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTVGAKGARAPK

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