Field Data
UniProt Accession: Q7Z628
Gene Name: NET1
Gene Synonim: ARHGEF8
GAP/GEF: GEF
Description: Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
Keywords: 3D-structure;Acetylation;Alternative splicing;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Nucleus;Phosphoprotein;Polymorphism;Proto-oncogene;Reference proteome
Entrez ID: 10276
Ensembl Gene ID: ENSG00000173848
Ensembl Protein ID: ENSP00000369717
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005634nucleus
GO:0005829cytosol
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding
GO:0017049GTP-Rho binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0071479cellular response to ionizing radiation
GO:0043547positive regulation of GTPase activity
GO:1900026positive regulation of substrate adhesion-dependent cell spreading
GO:0070301cellular response to hydrogen peroxide
GO:0043065positive regulation of apoptotic process
GO:0001558regulation of cell growth
GO:0007165signal transduction
GO:0035023regulation of Rho protein signal transduction
GO:0035556intracellular signal transduction
GO:0051451myoblast migration

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: nucleus, plasma_membrane
Localization in the literature: nucleus

Confocal Images

Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>NET1
atggtggcacatgatgagactggaggtctcctacctattaaaaggaccatacgagtccta
gatgtcaataaccagtccttcagagaacaagaggagccaagcaataaaagagttcgacct
ctggctcgtgtcacgtccttggcaaatttaatctctcctgtaagaaatggagctgtcaga
cgttttggtcaaacaatacagtcatttacccttcgtggtgaccacagatccccagcctct
gcccagaagttttctagcaggtcaacagtcccaacacccgccaagagaaggagcagtgca
ctgtggtcagagatgctggacatcaccatgaaggagtctctcaccaccagggagatcaga
cggcaggaggcaatatatgaaatgtcccgaggtgaacaggatttaattgaggatctcaaa
cttgcaagaaaggcctaccatgaccccatgttaaagttgtccatcatgtcagaagaggaa
ctcacacatatatttggtgatctggactcttacatacctctgcatgaagatttgttgaca
agaataggagaagcaaccaagcctgatggaacagtggagcagattggtcacattctcgtg
agctggttaccgcgcttgaatgcctacagaggttactgtagtaaccagctggcagccaaa
gctcttcttgatcaaaagaaacaggatccaagagtccaagacttcctccagcgatgtctc
gagtctcccttcagtcgaaaactagatctttggagtttcctagatatccctcgaagtcgc
ctagtcaaataccctttactgttaaaagaaattcttaaacacactccaaaagagcaccct
gatgttcagcttctggaggatgctatattgataatacagggagtcctctctgatatcaac
ttgaagaaaggtgaatccgagtgccagtattacatcgacaagctggagtacctggatgaa
aagcagagggaccccagaatcgaagcgagcaaagtgctgctgtgccatggggagctgcgg
agcaagagtggacataaactttacattttcctgtttcaagacatcttggttctgactcgg
cccgtcacacggaacgaacggcactcttaccaggtttaccggcagccaatcccagtccaa
gagctagtcctagaagacctgcaggatggagatgtgagaatgggaggctcctttcgagga
gctttcagtaactcagagaaagctaaaaatatctttagaattcgcttccatgacccctct
ccagcccagtctcacactctgcaagccaatgacgtgttccacaagcagcagtggttcaac
tgtattcgagcggccattgcccccttccagtcggcaggcagtccacctgagctgcagggc
ctgccggagctgcacgaagagtgtgaggggaaccacccctctgcgaggaaactcacagcc
cagaggagggcatccacagtttccagtgttactcaggtagaagttgatgaaaacgcttac
agatgtggctctggcatgcagatggcagaggacagcaagagcttaaagacacaccagaca
cagcccggcatccgaagagcgagggacaaagccctttctggtggcaaacggaaagagact
ttggtgttgatta

Protein Sequence

>NET1
MVAHDETGGLLPIKRTIRVLDVNNQSFREQEEPSNKRVRPLARVTSLANLISPVRNGAVR
RFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIR
RQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLT
RIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCL
ESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDIN
LKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTR
PVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPS
PAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTA
QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKET
LVLI

  • Gold
  • Silver
  • Bronze
  • IntAct