Field Data
UniProt Accession: Q7Z6B7
Gene Name: SRGAP1
Gene Synonim: ARHGAP13, KIAA1304
GAP/GEF: GAP
Description: SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)
Keywords: Alternative splicing;Coiled coil;Complete proteome;Disease mutation;GTPase activation;Phosphoprotein;Reference proteome;SH3 domain
Entrez ID: 57522
Ensembl Gene ID: ENSG00000196935
Ensembl Protein ID: ENSP00000347198
Our Specificity Rac1
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0048365Rac GTPase binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0030336negative regulation of cell migration
GO:0007165signal transduction
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle
R-HSA-428543Inactivation of CDC42 and RAC1

KEGG

Kegg ID Description
hsa04360Axon guidance
Field Data
Localization in this study: actin, focal_adhesions, plasma_membrane, puncta
Localization in the literature: nucleus

Confocal Images

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Cytochalasin D Screen Positive

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>SRGAP1
atgtccaccccgagccgattcaagaaggacaaagagatcatagccgagtatgaaagtcaa
gtcaaagaaattcgagctcaactggtagaacaacaaaaatgcctggagcagcaaacggag
atgcgagttcagcttctccaggatctgcaagatttcttccgaaaaaaagctgaaattgag
acggaatattcccggaatctagagaagttagcagaaaggttcatggcaaaaacaagaagc
actaaggatcatcaacaatacaagaaagaccagaacctgttgtctccagtgaactgctgg
tatttgctcctgaaccaagtaaggagagaaagcaaagaccatgcaaccttgagtgacatc
tatctgaacaatgtgattatgcggttcatgcagataagtgaggattctaccaggatgttt
aaaaagagcaaagagattgcattccaacttcatgaggatttaatgaaggttcttaatgag
ctttatacggtgatgaaaacataccatatgtatcatgcagagagcatcagtgcagagagc
aagctgaaagaggccgaaaaacaagaggaaaagcaaattgggagatctggtgatccagtc
ttccatattcgactagaggagagacatcaacggcgaagctctgtaaagaaaattgaaaaa
atgaaagaaaaaagacaagcaaaatattcagaaaataagctaaaatcaattaaggcacgg
aacgaatatctcctaacacttgaagccaccaatgcctcagttttcaagtactatattcat
gatctttctgatttaattgattgctgtgatcttggctaccatgcaagtctgaacagagcc
ctaagaacatatctgtctgcggagtacaaccttgaaacctccagacatgagggcttagac
attattgagaatgcagttgataatttagagcccaggagcgataagcagagattcatggag
atgtaccctgctgcgttctgtccaccaatgaagtttgagtttcagtctcacatgggtgat
gaggtgtgccaggtcagtgcccagcagccagtccaggcagagctcatgctcaggtaccaa
cagttgcagtcccgccttgccacgctcaaaatcgagaatgaagaggttaagaaaacgact
gaagccaccttgcagacgatacaagatatggtcaccatcgaggactatgatgtttctgaa
tgcttccagcacagtcgttccacagaatctgtgaagtccactgtctctgaaacctacctg
agtaaacccagcatcgccaagagaagagccaaccagcaggaaactgaacagttctacttc
atgaaactcagagaatatttggaaggcagtaatctcatcacaaaacttcaagccaaacat
gacttgctgcagaggaccctgggagaaggtcatagagctgaatatatgactacaaggcct
ccaaatgttccccctaagccccagaaacacaggaagtccaggccccgctcacagtataat
actaagttgtttaatggggatttggaaacattcgtcaaggactcaggacaggttattccc
ctcattgtggaaagctgtattcggttcatcaatctctatggtcttcagcatcaggggatt
ttcagagtgtctggttcccaggtggaagtcaatgatattaaaaattcatttgagagaggt
gaaaatcctttggctgatgaccagagtaaccatgatattaactcagttgctggcgttctg
aagctctatttccgtgggctggaaaaccccctctttcctaaggaaagatttaacgatctg
atttcttgtatcagaatagataatctctatgagagggcgcttcacatccgcaaactcctc
ctgactttgcccaggtcggtccttatagtgatgaggtacctctttgccttcctcaatcat
ctatcacagtacagcgatgagaatatgatggacccttataacctggccatttgctttggc
ccaacattgatgcctgtcccagaaatacaggatcaagtgtcttgccaggcacatgtgaat
gaaattatcaaaaccatcatcatccaccatgagactattttcccagatgctaaagagctg
gatggccctgtttatgagaaatgtatggctggagatgactattgcgacagcccatacagt
gagcacggtacattggaggaagtggaccaagatgctggtacagagccccacacaagtgaa
gatgaatgtgagccaatagaagcaatagccaagtttgactatgttgggcggtccgccaga
gaactatccttcaagaagggtgcctccctgctgctgtatcaccgtgcatctgaggactgg
tgggaaggcaggcacaacgggattgacgggctggtgcctcaccagtatatagtggtgcag
gatatggatgatacgttttcagacactctgagccaaaaagccgacagtgaggccagcagt
gggccagtcacggaagacaagtcctcatccaaggacatgaactccccgacagaccgtcat
cctgacggctatttagccaggcaacgaaaaagaggagagccaccccctccagtaaggcgt
cctggcaggaccagtgatggccattgcccgctccaccctccacatgccctttctaactcc
tcagttgacctagggtccccaagccttgccagtcacccccggggcctgctgcagaaccgt
ggcctcaacaatgacagtcctgagcggaggcgcaggcctggccatggcagcctgaccaac
atcagccggcacgactccctcaagaagatcgacagccctcccattagaaggtccacgtca
tcagggcaatacacgggcttcaatgaccacaagccactggacccagagacaattgctcag
gatattgaagaaacgatgaacacagctttgaatgaactccgagaactggagagacagagc
acagcaaagcatgcccctgatgtggtgctggataccctggagcaagtgaaaaactctccc
acccctgccacttccacggaatctctcagccctttgcacaacgttgccctcaggagctcc
gagcctcagattcgacgtagcacgagctcctccagtgacacaatgagtactttcaagcct
atggtggcacccagaatgggcgtgcagctgaagcctccagcccttaggccaaaacctgct
gttcttccaaaaacaaatcctaccataggacctgccccacctccccagggtccaacagac
aagtcatgcacaatgttaatta

Protein Sequence

>SRGAP1
MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE
TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI
YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES
KLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKAR
NEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLD
IIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQ
QLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL
SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRP
PNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGI
FRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDL
ISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
PTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYS
EHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDW
WEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH
PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNR
GLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQ
DIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSS
EPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTD
KSCTMLI

  • Gold
  • Silver
  • Bronze
  • IntAct