Field Data
UniProt Accession: Q7Z6I6
Gene Name: ARHGAP30
Gene Synonim:
GAP/GEF: GAP
Description: Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)
Keywords: Alternative splicing;Complete proteome;Cytoplasmic vesicle;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 257106
Ensembl Gene ID: ENSG00000186517
Ensembl Protein ID: ENSP00000356992
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0031410cytoplasmic vesicle
GO:0005829cytosol
GO:0043231intracellular membrane-bounded organelle

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007264small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: vesicles

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ARHGAP30
atgaagtctcggcagaaaggaaagaagaagggcagctctaaggaacgggtgtttgggtgt
gacctacgtgagcatctacagcactcgggccaggaagtgccccaggtgctacggagctgt
gcagagtttgtgcaagagtatggagtggtggatgggatctaccgcctctcaggggtctcc
tctaacatccagaagctccggcaggagtttgagacggagcggaagccagacctgcgccgg
gatgtttatctccaggacattcactgcgtctcttccttgtgcaaggcctacttcagagaa
ctcccagatcccctcctcacttatcggctctatgacaagtttgctgaggcagtggccgtg
cagctagagccagagcgattggtcaagatcctagaagtgcttcaagaactccctatccaa
aactacaggaccctggaattccttatgcgccacttggtccacatggcctcatttagtgcc
caaaccaacatgcatgctcgcaatctggcaattgtgtgggcccccaacctgctgaggtct
aaggacatagaggcctcaggcttcaatgggacagcagcgttcatggaggttcgagtgcag
tccattgttgtggagttcatccttacccatgtggaccagctctttaggggtgactccctc
tctgctggtgtagacttggagagtggatggaaatcacttccaggagcccgggcatcaggc
agctccgaggacctcatgcccacctctcttccctaccacttgcccagcatcttgcaggct
ggggatggacctccacagatccgaccctaccatactattattgagattgcggaacacaag
agaaaggggtcattgaaggtcaggaaatggcgctctatcttcaatttgggtcgatctgga
cacgagacaaaacgtaaacttccgctgagggttgaggacagggaagaaaaatccagtaag
gggacactgcggcctgccaaaagcatggactcgctgagtgctgccgctggggccagtgac
gagccggaggggctggtggggtccagcagttctcagccaagctcactgatgcctgagagt
ttggagagtaattctatggaaggtgaacaggagcctgaagcagaggcaccgggcagtgcc
aattctgagccgggaactccacgagccgggcgatcagctgttcgggccttaggtagcagt
agagcagagcgttgtgctggtgtccacatctcagacccttacaacgtcaacctccctctg
cacataacctccatcctcagtgttcctccaaacatcatctctaatgtctccttggtcagg
ctcacccgaggccttgagtgccctgccctacaaccccggccatgccctgccttgggtcct
ggccccccagatgagaaatcagaggcaagatcagtcccaggtcccctggatgactcgagc
cctgcagccatgactcctgccctagaggactccctgtcccaggaagtgcaggactccttc
tccttcctagaggatttgagcagctcagagcctgagtgggtgggggtggaggagagggag
gtggccaaggcagaagccgcaggagcagcaggagcagcagctttctcccttggggaggac
gaccctgggatgggctacctggaggagctgctgagagttgggcctcaggtagaagagttc
tctgtggagccacccctggatgacctgtctctggatgatactcagtatgtcctggctcct
aactgctgctcccttgattctgcggtttccacacctgacgtagaagaggactatggggaa
gaagtcttcttgagtgcctatgatgatctgagtccccttctggggcctaaacccatcaac
tgggaaggtgtagggagtctggaggaagaggcagcagggtgtgggaaacaacctccaaca
caggatgaagaagaacaggcctgctcagaaaccaggcaggaaaaggaggctaagccccgg
agcacatcagataaccgggaagaagcagaggcaactccagagactgagatggaggctgga
aaggctgatgcggaaggaggggaggctgagagaagccaaaaggtgatggatagttttaaa
gaagggagtagggaagagctagaggccaaggaagaaaattccgaaggtcgagaggttgaa
agtataaaggagaccaaggatgtggaaaaaataataggagaaccgggtaaagatgaggag
agagagattgggagagaagaaggagctgagaaaggagatgacaccccagtagactctgat
atggatccagagcatgtgttccaggaagacctggttcttgaggagagctgggaagttgtc
cacaagcatgaggctgagaaaggcagagagagtgagaccaaagagctgaggaggaagagt
gaccttaagtcaagagaagaccaaggacacagtgaagacagtggaagtccagaagagggt
gatgataggaaggaaggggttttcagcaaggaacaaaaaagtatagacgtagaaactgaa
gtcatgagaggtgttggtgaccacttagaagagggggccctctctgaagggccaggtgtc
gagttactgagggttgacagtacagaagaaatcaatgaacagacctctgagatgaaacaa
gccccgctacagccatctgaaccagagggcatggaggctgagggacagcttaatcctgag
acatgtgacctgtattcttgtccctgtgggtcagctggtggtgtgggcatgcgtctggct
tccaccctagttcaggtccgacaggtccgctctgtccctgtagtgccccccaaaccacag
tttgccaagatgcccagtgcaatgtgtagcaagatccatgtagcacctgcaagcccatgt
ccaaggcctggtaggcttgatgggactcctggagaaaaagcttggggttctcgagcttcc
tggaggaatgggggcagtctttcttttgatgctgctgtggccctggcccgggaacgccag
aggaccgagtctcagggagttctgcggacccagacctgtactggaggtggggattatagt
ctcagctccagaacccctccttgtagcatgatccttgcccattcttcccggccccttagc
tgtttggaacgcccacctgaaggcacagaggggtctgagcccaggagtcggcttagtctg
ccccctagagagcttcaccctgttgtccctcttgtggcccctcagcgccagacatatgct
tttgaaacacagactaatcatgggaaagatgaaggggtattaatta

Protein Sequence

>ARHGAP30
MKSRQKGKKKGSSKERVFGCDLREHLQHSGQEVPQVLRSCAEFVQEYGVVDGIYRLSGVS
SNIQKLRQEFETERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVAV
QLEPERLVKILEVLQELPIQNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRS
KDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFRGDSLSAGVDLESGWKSLPGARASG
SSEDLMPTSLPYHLPSILQAGDGPPQIRPYHTIIEIAEHKRKGSLKVRKWRSIFNLGRSG
HETKRKLPLRVEDREEKSSKGTLRPAKSMDSLSAAAGASDEPEGLVGSSSSQPSSLMPES
LESNSMEGEQEPEAEAPGSANSEPGTPRAGRSAVRALGSSRAERCAGVHISDPYNVNLPL
HITSILSVPPNIISNVSLVRLTRGLECPALQPRPCPALGPGPPDEKSEARSVPGPLDDSS
PAAMTPALEDSLSQEVQDSFSFLEDLSSSEPEWVGVEEREVAKAEAAGAAGAAAFSLGED
DPGMGYLEELLRVGPQVEEFSVEPPLDDLSLDDTQYVLAPNCCSLDSAVSTPDVEEDYGE
EVFLSAYDDLSPLLGPKPINWEGVGSLEEEAAGCGKQPPTQDEEEQACSETRQEKEAKPR
STSDNREEAEATPETEMEAGKADAEGGEAERSQKVMDSFKEGSREELEAKEENSEGREVE
SIKETKDVEKIIGEPGKDEEREIGREEGAEKGDDTPVDSDMDPEHVFQEDLVLEESWEVV
HKHEAEKGRESETKELRRKSDLKSREDQGHSEDSGSPEEGDDRKEGVFSKEQKSIDVETE
VMRGVGDHLEEGALSEGPGVELLRVDSTEEINEQTSEMKQAPLQPSEPEGMEAEGQLNPE
TCDLYSCPCGSAGGVGMRLASTLVQVRQVRSVPVVPPKPQFAKMPSAMCSKIHVAPASPC
PRPGRLDGTPGEKAWGSRASWRNGGSLSFDAAVALARERQRTESQGVLRTQTCTGGGDYS
LSSRTPPCSMILAHSSRPLSCLERPPEGTEGSEPRSRLSLPPRELHPVVPLVAPQRQTYA
FETQTNHGKDEGVLI

  • Gold
  • Silver
  • Bronze
  • IntAct