Field Data
UniProt Accession: Q7Z6J4
Gene Name: FGD2
Gene Synonim: ZFYVE4
GAP/GEF: GEF
Description: FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)
Keywords: Alternative splicing;Cell membrane;Cell projection;Complete proteome;Cytoplasm;Cytoskeleton;Endosome;Guanine-nucleotide releasing factor;Membrane;Metal-binding;Nucleus;Phosphoprotein;Polymorphism;Reference proteome;Repeat;Zinc;Zinc-finger
Entrez ID: 221472
Ensembl Gene ID: ENSG00000146192
Ensembl Protein ID: ENSP00000274963
Our Specificity Cdc42
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0001726ruffle
GO:0016020membrane
GO:0005829cytosol
GO:0030027lamellipodium
GO:0005634nucleus
GO:0005856cytoskeleton
GO:0032587ruffle membrane
GO:0005886plasma membrane
GO:0042995cell projection
GO:0005768endosome
GO:0005769early endosome
GO:0031901early endosome membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0031267small GTPase binding
GO:0005515protein binding
GO:1901981phosphatidylinositol phosphate binding
GO:0046872metal ion binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007010cytoskeleton organization
GO:0043547positive regulation of GTPase activity
GO:0030036actin cytoskeleton organization
GO:0043065positive regulation of apoptotic process
GO:0008360regulation of cell shape
GO:0035023regulation of Rho protein signal transduction
GO:0043507positive regulation of JUN kinase activity
GO:0046847filopodium assembly
GO:0043087regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: actin
Localization in the literature: vesicles, plasma membrane

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>FGD2
atgaagggggcaagtgaggagaagctggcatctgtgtccaacctggtcactgtgtttgag
aatagcaggaccccagaagcagcacccagaggccacaggctagaggacgtgcatcaccgc
cctgagtgcaggcctcccgagtccccaggaccacgggagaagacgaatgtcggggaggcc
gtggggtctgagcccaggacagtcagcaggaggtacctgaactccctgaagaacaagctg
tccagcgaagcctggaggaaatcttgccagcctgtgaccctctcaggatcggggacgcag
gagccagagaagaagatcgtccaggagctgctggagacagagcaggcctatgtggcgcgc
ctccacctgctagaccaggtgtttttccaggagctgctgaagacagcccgcagcagcaag
gccttcccagaggatgtggtcagggtcatcttctccaacatctcctccatctatcagttc
cattctcagttcttcctcccagagctgcagcggcgcctggacgactggacagctaacccc
cgcatcggtgacgtgatccagaagctggcccccttcctgaagatgtacagtgagtatgtc
aagaactttgagcgagcggctgagctgctggccacctggaccgacaagtctccactcttc
caggaggttctcactcgcatccagagcagcgaggcttcgggcagcctgaccctgcagcac
cacatgctggaaccagtgcagagaattccacgttacgagctgctgctcaaggagtacatc
cagaagctgccagcccaggccccagaccaggccgatgcccagaaagccctggacatgatc
ttctcagctgcccagcactccaatgcagccatcactgagatggagcggctgcaggacctg
tgggaggtgtaccagcgcctgggcctcgaggacgacatagtagacccctctaacaccctg
ctccgtgagggcccggtcctcaagatctccttccgccgcaacgaccccatggagcgctac
cttttcttgttcaacaacatgctgctctactgtgtgcccagggtgatccaggtgggcgcc
cagttccaggtgaggacccgcatcgatgtggccgggatgaaggtgcgggagctgatggat
gctgagtttccccactccttcctggtgtccgggaagcagcgcaccctggagctgcaagcc
cggtcccaggaggaaatgatttcctggatgcaggccttccaagcagccattgaccaaatc
gagaagcggaatgaaaccttcaaggctgcggcccaggggcctgagggagacatccaggag
caggagctgcagtctgaggagctgggcctccgggcaccgcagtgggtccgggacaagatg
gtgaccatgtgcatgcgctgccaggagcccttcaacgctctgacgcgccgtcgccaccac
tgccgggcctgcggctatgtggtgtgtgccaggtgctccgactaccgggccgaactgaaa
tacgacgacaacaggcccaaccgagtctgcctccactgctacgcattcctcactggaaat
gtgctgcctgaggccaaggaggacaagaggcggggcatcctggagaaagggtcctcagcc
acgcctgaccagagcctgatgtgcagcttcctgcagctcatcggggacaagtggggcaag
agcggcccccggggctggtgtgtgatccctcgggatgaccccctcgtgctctatgtctat
gctgcccctcaggacatgagggctcacacctccatccccctgctgggctaccaggtgact
gttgggccccagggggaccctcgggtcttccagctacagcagtcaggccagctctacacc
ttcaaggccgagacggaggagctgaagggccgctgggtgaaggccatggagcgggcggcc
agtggctggagccccagctggcccaacgatggggacctgtccgacggaagctt

Protein Sequence

>FGD2
MKGASEEKLASVSNLVTVFENSRTPEAAPRGHRLEDVHHRPECRPPESPGPREKTNVGEA
VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSDGS

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  • IntAct