Field Data
UniProt Accession: Q86VW2
Gene Name: ARHGEF25
Gene Synonim: GEFT
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 25 (Guanine nucleotide exchange factor GEFT) (Rac/Cdc42/Rho exchange factor GEFT) (RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT) (p63RhoGEF)
Keywords: 3D-structure;Alternative splicing;Cell membrane;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Membrane;Polymorphism;Reference proteome
Entrez ID: 115557
Ensembl Gene ID: ENSG00000240771
Ensembl Protein ID: ENSP00000484303
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane
GO:0030016myofibril
GO:0030017sarcomere
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-416476G alpha (q) signalling events

KEGG

Field Data
Localization in this study: plasma_membrane
Localization in the literature: plasma membrane

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF25
atgttggagccagctctagccacaggagaggagctgccggaactgaccttgctgaccaca
ctgttggagggccctggagataagacgcagccacctgaagaggagactttgtcccaagcc
cctgagagtgaggaggaacagaagaagaaggctctggaaaggagtatgtatgtcctgagt
gaactggtagaaacagagaaaatgtacgtggacgacttggggcagattgtggagggttat
atggccaccatggctgctcagggggtccccgagagtcttcgaggccgtgacaggattgtg
tttgggaatatccagcaaatctatgagtggcaccgagactatttcttgcaagagctacaa
cggtgtctgaaagatcctgattggctggctcagctattcatcaaacacgagcgccggctg
catatgtatgtggtgtactgtcagaataagcccaagtcagagcatgtggtgtcagagttt
ggggacagctactttgaggagctccggcagcagctggggcaccgcctgcagctgaacgac
ctcctcatcaaacctgtgcagcggatcatgaaataccagctgctgctcaaggattttctc
aagtattacaatagagctgggatggatactgcagacctagagcaagctgtggaggtcatg
tgctttgtgcccaagcgctgcaacgatatgatgacgctggggagattgcggggatttgag
ggcaaactgactgctcaggggaagctcttgggccaggacactttctgggtcaccgagcct
gaggctggagggctgctgtcttcccgaggtcgagagaggcgcgtcttcctctttgagcaa
atcatcatcttcagtgaagccctgggaggaggagtgagaggtggaacacagcctggatat
gtatacaagaacagcattaaggtgagctgcctgggactggaggggaacctccaaggtgac
ccttgccgctttgcactgacctccagagggccagagggtgggatccagcgctatgtcctg
caggctgcagaccctgctatcagtcaggcctggatcaagcatgtggctcagatcttggag
agccaacgggacttcctcaacgcattgcagtcacccattgagtaccagagacgggagagc
cagaccaacagcctggggcggccaagagggcctggagtggggagccctggaagaattcgg
cttggagatcaggcccagggcagcacacacacacccatcaatggctctctcccctctctg
ctgctgtcacccaaaggggaggtggccagagccctcttgccactggataaacaggccctt
ggtgacatcccccaggctccccatgactctcctccagtctctccaactccaaaaacccct
ccctgccaagccagacttgccaagctggatgaagatgagctgtaa

Protein Sequence

>ARHGEF25
MLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLS
ELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQ
RCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLND
LLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFE
GKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGY
VYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILE
SQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIRLGDQAQGSTHTPINGSLPSL
LLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL

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